Objectives:To assess the impact of clinical pharmacist counselling and education on Quality of Life (QoL) of patients with acute coronary syndrome (ACS). Methodology: A prospective interventional study was conducted for a period of 8 months. The ACS patients were categorized into intervention and control groups by randomization process. The intervention group was given patient counselling and patient information leaflets along with the usual care while the control group received only the usual care. The patient counselling, education and leaflets were provided only at the end of the study to the control group. The QoL of patients was assessed by WHOQOL-BREF questionnaire at baseline, third month and sixth month of the study. The change in QoL scores between the two groups over a period was analysed by Repeated Measures of ANOVA with p value less than 0.05 was considered as statistically significant. Results: A total number of 130 patients (65 patients in the intervention group and 65 in the control group) were enrolled in the study. The mean age for the intervention group was 60.23 ± 10.07 years and for control group was 57.85± 10.67 years. There is no significant difference in the QoL scores of Physical, Psychological, Social Relationships and Environment domains between the two groups with p value more than 0.05. Conclusion: There was no statistically significant change in QoL scores of the ACS patients. However, there is an improvement in the QoL scores of the intervention group to that of the control group.