Quality of life after radiation therapy of cerebral low-grade gliomas of the adult: results of a randomised Phase III trial on dose response (EORTC trial 22844)

Effect of radiotherapy and other treatment-related factors on mid-term to long-term cognitive sequelae in low-grade gliomas: a comparative study

“…5 Findings of several studies by the European Organisation for the Research and Treatment of Cancer (EORTC) clearly do not recommend early treatment with radiotherapy of patients with low-grade gliomas. 7,8 Apart from potential favourable survival effects, radiotherapy itself could negatively affect the patient's health-related quality of life through irreversible late-delayed brain damage induced by irradiation, ultimately resulting in cognitive deficits and dementia. 9,10 In long-term survivors of brain metastases from systemic cancer, and in patients with primary lymphoma of the central nervous system, treatment with whole-brain radiotherapy can lead to radiation-induced encephalopathy.…”

Fatigue in low-grade glioma

“…Few studies assessed fatigue in LGG patients [15][16][17]. In one quality of life study, fatigue is mentioned as a problem for the majority of glioma patients [15].…”

“…However, the level of fatigue and its associated factors have not been studied extensively in LGG patients. Studies assessing fatigue in this patient group mostly use only a limited number of items from a quality of life instrument [15][16][17]. However, the most comprehensive approach to assess fatigue would be using a multidimensional instrument [18], because fatigue is a multidimensional concept with several modes of expression (physical, cognitive, and affective) [7].…”

Interstitial 125I radiosurgery of supratentorial de novo WHO Grade 2 astrocytoma and oligoastrocytoma in adults

“…However, patients treated with a higher tumor dose (in the range of 60 Gy) experienced more side effects of therapy. 20 Whether these somehow disappointing results reflect the well known clinical and biologic heterogeneity of this tumor entity (confounding beneficial treatment effects of external-beam radiation for not yet identified subpopulations) or the predominant role of treatment independent factors remains unclear. Unfortunately, proposals for comparisons of conservative management (wait-and-see attitude after stereotactic biopsy) and more aggressive treatment strategies have not been realized.…”