Quality of Life After Severe Trauma: Results From the Global Trauma Trial With Recombinant Factor VII

Christensen, Michael Cronquist; Banner, Claus; Lefering, Rolf; Vallejo-Torres, Laura; Morris, Stephen F.

doi:10.1097/ta.0b013e3181f053c2

Cited by 36 publications

(41 citation statements)

References 17 publications

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“…Three of the 34 studies were RCT's, involving 1086 participants [26]–[28]. One described a specific rehabilitation intervention using cognitive behavioural therapy to reduce post-traumatic stress and improve quality of life [27]; the other study, evaluated the impact of recombinant Factor VII on long term health outcome after severe trauma [26]. The largest RCT (n = 568) evaluated the cost effectiveness of nurse led telephone follow-up to improve quality of life for discharged trauma patients.…”

Section: Resultsmentioning

confidence: 99%

“…The remainder were retrospective studies (n = 6751). Collectively the studies were conducted in different countries and continents: Seven in the USA [29]–[35]; six in Australasia (four in Australia and two in New Zealand) [36]–[41]; 19 in Europe (five in Germany [27], [42]–[45], four each in The Netherlands [46]–[49] and Norway [8], [9], [50], [51], two each in the UK [24], [25] and Sweden [28], [52], one each in Switzerland [53], Denmark [26] and one each in Israel [54] and South Africa [55] (Table 1, Table S3). …”

Section: Resultsmentioning

confidence: 99%

“…The TOP was the only trauma specific measure, although cited only once [26]. The TOP had the largest ICF representation with 61 categories (bandwidth = 16.8%) and covered seventeen ICF chapters (57%).…”

Section: Resultsmentioning

confidence: 99%

“…While the consistent application of the SF-36 could allow international comparison of trauma outcome, it captures only a small proportion of health outcomes. The measure with the greatest ICF representation (TOP) was cited only once [26] and also requires further validation studies [62]. Only one measure was developed within the ICF framework (WHODAS ll).…”

Section: Discussionmentioning

confidence: 99%

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Health Outcome after Major Trauma: What Are We Measuring?

et al. 2014

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ImportanceTrauma is a global disease and is among the leading causes of disability in the world. The importance of outcome beyond trauma survival has been recognised over the last decade. Despite this there is no internationally agreed approach for assessment of health outcome and rehabilitation of trauma patients.ObjectiveTo systematically examine to what extent outcomes measures evaluate health outcomes in patients with major trauma.Data SourcesMEDLINE, EMBASE, and CINAHL (from 2006–2012) were searched for studies evaluating health outcome after traumatic injuries.Study selection and data extractionStudies of adult patients with injuries involving at least two body areas or organ systems were included. Information on study design, outcome measures used, sample size and outcomes were extracted. The World Health Organisation International Classification of Function, Disability and Health (ICF) were used to evaluate to what extent outcome measures captured health impacts.Results34 studies from 755 studies were included in the review. 38 outcome measures were identified. 21 outcome measures were used only once and only five were used in three or more studies. Only 6% of all possible health impacts were captured. Concepts related to activity and participation were the most represented but still only captured 12% of all possible concepts in this domain. Measures performed very poorly in capturing concepts related to body function (5%), functional activities (11%) and environmental factors (2%).ConclusionOutcome measures used in major trauma capture only a small proportion of health impacts. There is no inclusive classification for measuring disability or health outcome following trauma. The ICF may provide a useful framework for the development of a comprehensive health outcome measure for trauma care.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Health Outcome after Major Trauma: What Are We Measuring?

et al. 2014

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“…Previous studies showed that the (HR)QOL of severely injured patients is lower than that of the general population. [2][3][4][5][6][7][8] This decrease in (HR)QOL seems to depend on both psychological complaints and physical limitations, but few studies measured these three parameters within the same study population.…”

Section: Introductionmentioning

confidence: 99%

The relationship between physical and psychological complaints and quality of life in severely injured patients

Delft-Schreurs

Son²,

Jongh

et al. 2017

Injury

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Purpose: The purpose of this study was two-fold. The first goal was to investigate which variables were associated with the remaining physical limitations of severely injured patients after the initial rehabilitation phase. Second, we investigated whether physical limitations were attributable to the association between psychological complaints and quality of life in this patient group. Differences in physical limitations were investigated for several trauma-and patient-related variables using non-parametric independent-sample Mann-Whitney U tests. Multiple linear regression was performed to investigate whether the decreased QOL of severely injured patients with psychological complaints could be explained by their physical limitations. Results:Older patients, patients with physical complaints before the injury, patients with higher ISS scores, and patients who had an injury of the spine or of the lower extremities reported significantly more physical problems. Additionally, patients with a low education level, patients who were living alone, and those who were unemployed reported significantly more long-term physical problems.Severely injured patients without psychological complaints reported significantly less physical limitations than those with psychological complaints. The SMFA factor of Lower extremity dysfunction was a confounder of the association between psychological complaints and QOL in all QOL domains.Conclusions: Long-term physical limitations were mainly reported by patients with psychological complaints. The decreased QOL of severely injured patients with psychological complaints can partially be explained by physical limitations, particularly those involving lower extremity function. Experienced physical limitations were significantly different for some trauma and patient characteristics. These characteristics may be used to select patients for whom a rehabilitation programme would be useful.

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