Quality of Life After Treatment for Localized Prostate Cancer: Differences Based on Treatment Modality

Davis, John W.; Kuban, Deborah A.; Lynch, Donald F.; Schellhammer, Paul F.

doi:10.1016/s0022-5347(05)65870-3

Cited by 147 publications

(83 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[20][21][22] Our observations were compatible with these reports, and we showed that IMRT had a similar impact on bowel function and bothersomeness to 3DCRT. Regarding sexual function, Litwin et al 23 reported that patients undergoing XRT for early-stage prostate cancer began to show declining sexual function during the second year after treatment.…”

Section: Discussionsupporting

confidence: 92%

Health-related quality-of-life after external beam radiation therapy for localized prostate cancer: intensity-modulated radiation therapy versus conformal radiation therapy

Yoshimura

Nakamura

Segawa

et al. 2006

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

We compared health-related quality-of-life (HRQL) after intensity-modulated radiotherapy (IMRT) with statuses obtained after old and new protocols of three-dimensional conformal radiation therapy (3DCRT) for localized prostate cancer. We measured the general and disease specific HRQL using the MOS 36-Item Health Survey (SF-36), and the University of California, Los Angeles Prostate Cancer Index (UCLA PCI), respectively. IMRT resulted in similar profiles of general and disease-specific HRQL to two other methods within the first year after treatment. Moreover, IMRT gave rise to comparable urinary, intestinal and sexual side effects despite the high dose of radiation applied.

show abstract

Section: Discussionsupporting

confidence: 92%

Health-related quality-of-life after external beam radiation therapy for localized prostate cancer: intensity-modulated radiation therapy versus conformal radiation therapy

Yoshimura

Nakamura

Segawa

et al. 2006

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

show abstract

“…The questionnaire submission rates among these patients were 95%, 97%, 100%, 91%, 99%, 100%, 91% and 87% at 3,6,12,18,24,36,48 and 60 months after treatment, respectively. The mean HRQOL scores are shown in Figure 1 (general scales).…”

Section: General Hrqol Assessmentmentioning

confidence: 91%

“…There were no treatment-related deaths. Only patients with preoperative HRQOL data and data from at least two later times (3,6,12,18,24,36,48 or 60 months after surgery) were included in the analysis, resulting in a final study cohort of 143 subjects. Table 1 lists the selected demographic and clinical characteristics of the study sample.…”

Section: Background Characteristics Of the Study Groupmentioning

confidence: 99%

Quality of life after radical prostatectomy in Japanese men: A 5‐Year follow up study

Namiki¹,

Ishidoya²,

Ito³

et al. 2008

Int J of Urology

View full text Add to dashboard Cite

Objectives: To measure health-related quality of life (HRQOL) after radical prostatectomy (RP) in Japanese men with localized prostate cancer. Methods: A total of 154 patients who underwent RP were included in this 5-year longitudinal survey. The Short Form 36-Item Health Survey, the University of California, Los Angeles, Prostate Cancer Index and the International Prostate Symptom Score questionnaires were administered at diagnosis and nine times afterwards. Results: Patients undergoing RP showed problems in some physical domains of general HRQOL, but these problems diminished over time. Mental health and social functions significantly improved during the follow-up period. The urinary function substantially declined at 3 months and continued to recover gradually but never returned to baseline. Most patients (95%) recovered to their baseline urinary bother score within 60 months. The overall mean total International Prostate Symptom Score progressively improved with time. On the other hand , at 60 months after RP, only 34% of subjects had fully returned to baseline sexual function. By 5 years postoperatively, 78% of the men had reached baseline sexual bother and the mean recovery time was 8.6 months. Adverse effects of RP on sexual function and bother were mitigated by bilateral nervesparing procedures up to 5 years after the operation. Conclusions: Despite reported problems with sexuality and urinary continence, general HRQOL was mostly unaffected by RP after 6 months in our survey with functional outcomes remaining relatively stable in the majority of patients.Key words: longitudinal study, prostate cancer, quality of life, radical prostatectomy. IntroductionCurrently, the most common therapeutic options for localized prostate cancer are radical prostatectomy (RP), external radiation, and interstitial brachytherapy. RP is considered an especially safe and effective treatment for localized prostate cancer and has gained popularity among Japanese urologists over the last decade.1 As prostate cancer is increasingly diagnosed at early stages and therefore with more favorable survival outcomes, the basis on which patients select primary therapy has shifted toward considerations of health-related quality of life (HRQOL). 2,3Accordingly, HRQOL assessment has become an important form of outcome-based research that may weigh heavily on the justification of health care expenditures and the treatment selection by patients.Several assessments of HRQOL after prostate cancer treatment have been limited to studies of non-Hispanic whites, African-Americans, and Hispanics in the USA.4,5 Previously, we detailed HRQOL recovery in Japanese men with localized prostate cancer followed for 2 years after RP. 6 In the current analysis we assessed temporal changes in HRQOL up to 5 years following RP using validated questionnaires. To our knowledge the current study is the longest-term prospective study to assess the impact of RP on general and disease-specific outcomes following RP in Japanese men with clinically localized prostate can...

show abstract

“…54 However, the risk of retention following brachytherapy is appreciable and highlights the importance of careful case selection to minimise this significant, although temporary deterioration in urinary symptoms. Quality-of-life studies suggest that the greatest deterioration in urinary continence and sexual function occurs in patients treated by radical prostatectomy compared to brachytherapy 55,56 although often more global quality of life measures remain similar. 50,57 Patient selection issues for brachytherapy Patient selection for prostate brachytherapy involves both cancer issues as well as more general urological issues.…”

Section: Complicationsmentioning

confidence: 99%

Iodine seed prostate brachytherapy: an alternative first-line choice for early prostate cancer

Langley

Laing

2004

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

This article on permanent iodine-125 seed prostate brachytherapy reviews the techniques, results, and patient selection issues for early prostate cancer. The longterm 10 y results of brachytherapy from Seattle, and their reproducibility in other centres both in the USA and UK are reported. The use of hormone therapy in brachytherapy and the value of combining external beam radiotherapy with a brachytherapy implant are discussed. Reviewed comparative data show the similarity of biochemical survival in patients treated with brachytherapy, radical prostatectomy, and external beam radiotherapy. The role of brachytherapy as a first-line treatment option for patients with prostate cancer is demonstrated.

show abstract

Quality of Life After Treatment for Localized Prostate Cancer: Differences Based on Treatment Modality

Abstract: While general health related quality of life was mostly unaffected by the 3 most common treatments for prostate cancer, there were differences in bowel, urinary and sexual function. This information may aid patients in the decision making process.

Cited by 147 publications

References 16 publications

Health-related quality-of-life after external beam radiation therapy for localized prostate cancer: intensity-modulated radiation therapy versus conformal radiation therapy

Health-related quality-of-life after external beam radiation therapy for localized prostate cancer: intensity-modulated radiation therapy versus conformal radiation therapy

Quality of life after radical prostatectomy in Japanese men: A 5‐Year follow up study

Iodine seed prostate brachytherapy: an alternative first-line choice for early prostate cancer

Contact Info

Product

Resources

About