Quality of life among breast cancer patients with lymphedema: a systematic review of patient-reported outcome instruments and outcomes

Pusic, Andrea L.; Cemal, Yeliz; Albornoz, Claudia R.; Klassen, Anne F.; Cano, Stefan; Sulimanoff, Isabel; Hernandez, Marisol; Massey, Marga F.; Cordeiro, Peter G.; Morrow, Monica; Mehrara, Babak J.

doi:10.1007/s11764-012-0247-5

Cited by 204 publications

(166 citation statements)

References 44 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…Latina women were found to experience poorer qol than their non-Latina counterparts 33 . Additionally, bca-related lymphedema and higher levels of fatigue were significantly associated with poorer qol 28,29 . The other factors that were associated with qol were poorer mental and physical health, poor social functioning, greater distress, and greater fear of recurrence.…”

Section: Quality Of Lifementioning

confidence: 93%

“…Of the included reviews, thirteen reported challenges faced by bca patients and survivors [27][28][29][30][31][32][33][34][35][36][37][38]40 . Their findings are categorized and described next.…”

Section: Cancer-or Cancer Treatment-related Challengesmentioning

confidence: 99%

“…Seven reviews reported on the quality of life (qol) of bca patients and survivors 28,29,[32][33][34][35]37 , and according to those reviews, bca patients and survivors often experience poorer qol. Two reviews found an association between qol and age, with considerably poorer qol being experienced by younger (≤50 years of age) than by older bca patients and survivors 32,34 .…”

Section: Quality Of Lifementioning

confidence: 99%

“…Two reviews reported on bca-related lymphedema 27,29 . One estimated the risk for lymphedema based on the treatment that the bca patients received, and they observed that the risk for lymphedema was higher in patients who underwent mastectomy than in those who underwent lumpectomy; higher in those who had an axillary dissection than in those who had no axillary dissection; higher in those who underwent axillary dissection than in those who had a sentinel lymph node biopsy; and higher in those who received radiation and in those who had positive axillary nodes than in those who did not.…”

Section: Lymphedemamentioning

confidence: 99%

“…One estimated the risk for lymphedema based on the treatment that the bca patients received, and they observed that the risk for lymphedema was higher in patients who underwent mastectomy than in those who underwent lumpectomy; higher in those who had an axillary dissection than in those who had no axillary dissection; higher in those who underwent axillary dissection than in those who had a sentinel lymph node biopsy; and higher in those who received radiation and in those who had positive axillary nodes than in those who did not. The second review reported on the effect of lymphedema on qol in bca patients and survivors, finding that lymphedema was significantly associated with poor physical, psychological, and social well-being, and with poorer qol, with the effects being more pronounced in younger survivors (<40 years of age) 29 .…”

Section: Lymphedemamentioning

confidence: 99%

See 4 more Smart Citations

Survivorship Care Plans for Breast Cancer Patients: Understanding the Quality of the Available Evidence

2017

View full text Add to dashboard Cite

AimThe overall goal of the present study was to contribute to consistency in the provincial approach to survivorship care planning through knowledge synthesis and exchange. Our review focused on the research concerning the physical and emotional challenges of breast cancer (bca) patients and survivors and the effects of the interventions that have been used for lessening those challenges. MethodsThe psychosocial topics identified in bca survivorship care plans created by two different initiatives in our province provided the platform for our search criteria: quality of life (qol), sexual function, fatigue, and lifestyle behaviours. We conducted an umbrella review to retrieve the best possible evidence, and only reviews investigating the intended outcomes in bca survivors and having moderate-to-high methodologic quality scores were included. ResultsOf 486 reports retrieved, 51 reviews met the inclusion criteria and form part of the synthesis. Our results indicate that bca patients and survivors experience numerous physical and emotional challenges and that interventions such as physical activity, psychoeducation, yoga, and mindfulness-based stress reduction are beneficial in alleviating those challenges. ConclusionsOur study findings support the existing survivorship care plans in our province with respect to the physical and emotional challenges that bca survivors often face. However, the literature concerning cancer risks specific to bca survivors is scant. Although systematic reviews are considered to be the "gold standard" in knowledge synthesis, our findings suggest that much remains to be done in the area of synthesis research to better guide practice in cancer survivorship.

show abstract

Section: Quality Of Lifementioning

confidence: 93%

Section: Cancer-or Cancer Treatment-related Challengesmentioning

confidence: 99%

Section: Quality Of Lifementioning

confidence: 99%

Section: Lymphedemamentioning

confidence: 99%

Section: Lymphedemamentioning

confidence: 99%

See 3 more Smart Citations

Survivorship Care Plans for Breast Cancer Patients: Understanding the Quality of the Available Evidence

2017

View full text Add to dashboard Cite

show abstract

Quality of Life Following Receipt of Adjuvant Chemotherapy With and Without Bevacizumab in Patients With Lymph Node–Positive and High-Risk Lymph Node–Negative Breast Cancer

et al. 2022

View full text Add to dashboard Cite

IMPORTANCE Breast cancer treatment can impact not only short-term health but may also affect longer-term quality of life (QOL).OBJECTIVE To describe and evaluate factors associated with diminished QOL following completion of active treatment. DESIGN, SETTING, AND PARTICIPANTSThis was a secondary analysis of a randomized clinical trial included patients with lymph node-positive or high-risk lymph node-negative breast cancer who had undergone definitive surgery and were enrolled in ECOG-ACRIN E5103, a multisite phase 3 trial.

show abstract

Feasibility and Clinical Utility of Prediction Models for Breast Cancer–Related Lymphedema Incorporating Racial Differences in Disease Incidence

et al. 2023

View full text Add to dashboard Cite

ImportanceBreast cancer–related lymphedema (BCRL) is a common complication of axillary lymph node dissection (ALND) but can also develop after sentinel lymph node biopsy (SLNB). Several models have been developed to predict the risk of disease development before and after surgery; however, these models have shortcomings that include the omission of race, inclusion of variables that are not readily available to patients, low sensitivity or specificity, and lack of risk assessment for patients treated with SLNB.ObjectiveTo create simple and accurate prediction models for BCRL that can be used to estimate preoperative or postoperative risk.Design, Setting, and ParticipantsIn this prognostic study, women with breast cancer who underwent ALND or SLNB from 1999 to 2020 at Memorial Sloan Kettering Cancer Center and the Mayo Clinic were included. Data were analyzed from September to December 2022.Main Outcomes and MeasuresDiagnosis of lymphedema based on measurements. Two predictive models were formulated via logistic regression: a preoperative model (model 1) and a postoperative model (model 2). Model 1 was externally validated using a cohort of 34 438 patients with an International Classification of Diseases diagnosis of breast cancer.ResultsOf 1882 included patients, all were female, and the mean (SD) age was 55.6 (12.2) years; 80 patients (4.3%) were Asian, 190 (10.1%) were Black, 1558 (82.8%) were White, and 54 (2.9%) were another race (including American Indian and Alaska Native, other race, patient refused to disclose, or unknown). A total of 218 patients (11.6%) were diagnosed with BCRL at a mean (SD) follow-up of 3.9 (1.8) years. The BCRL rate was significantly higher among Black women (42 of 190 [22.1%]) compared with all other races (Asian, 10 of 80 [12.5%]; White, 158 of 1558 [10.1%]; other race, 8 of 54 [14.8%]; P &lt; .001). Model 1 included age, weight, height, race, ALND/SLNB status, any radiation therapy, and any chemotherapy. Model 2 included age, weight, race, ALND/SLNB status, any chemotherapy, and patient-reported arm swelling. Accuracy was 73.0% for model 1 (sensitivity, 76.6%; specificity, 72.5%; area under the receiver operating characteristic curve [AUC], 0.78; 95% CI, 0.75-0.81) at a cutoff of 0.18, and accuracy was 81.1% for model 2 (sensitivity, 78.0%; specificity, 81.5%; AUC, 0.86; 95% CI, 0.83-0.88) at a cutoff of 0.10. Both models demonstrated high AUCs on external (model 1: 0.75; 95% CI, 0.74-0.76) or internal (model 2: 0.82; 95% CI, 0.79-0.85) validation.Conclusions and RelevanceIn this study, preoperative and postoperative prediction models for BCRL were highly accurate and clinically relevant tools comprised of accessible inputs and underscored the effects of racial differences on BCRL risk. The preoperative model identified high-risk patients who require close monitoring or preventative measures. The postoperative model can be used for screening of high-risk patients, thus decreasing the need for frequent clinic visits and arm volume measurements.

show abstract

Quality of life among breast cancer patients with lymphedema: a systematic review of patient-reported outcome instruments and outcomes

Cited by 204 publications

References 44 publications

Survivorship Care Plans for Breast Cancer Patients: Understanding the Quality of the Available Evidence

Survivorship Care Plans for Breast Cancer Patients: Understanding the Quality of the Available Evidence

Quality of Life Following Receipt of Adjuvant Chemotherapy With and Without Bevacizumab in Patients With Lymph Node–Positive and High-Risk Lymph Node–Negative Breast Cancer

Feasibility and Clinical Utility of Prediction Models for Breast Cancer–Related Lymphedema Incorporating Racial Differences in Disease Incidence

Contact Info

Product

Resources

About