Quality of life among Oral Potentially Malignant Disorder (OPMD) patients: A prospective study

Kumar, Kapila; Khandpur, Mani; Khandpur, Sukhanshi; Mehrotra, Divya; Tiwari, Sunil Kumar; Kumar, Sumit

doi:10.1016/j.jobcr.2020.11.009

Cited by 6 publications

(4 citation statements)

References 27 publications

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“…No specific protocol studies were found to learn about communicating the clinical and psychological impacts on patients who are diagnosed with OPMD. However, during the literature search carried out in this study, we observed that there are many studies concerning the quality of life of patients diagnosed with OPMDs, particularly, those related to lichen planus, leukoplakia, and oral submucous fibrosis [ 8 , 9 , 10 , 11 , 12 , 13 ]. The findings of these studies suggested that, in general, the signs and symptoms generated by OPMDs are the most important factors due to physical impairment and functional limitations.…”

Section: Discussionmentioning

confidence: 95%

“…Delivering bad news has been widely studied in oncological settings, however, communication protocols for the diagnosis of OPMDs are unknown, even with knowing the clinical and psychosocial impact. Thus, this review seeks the relevant and sensitive aspects of communication following the diagnosis of an OPMD, emphasizing topics such as the risk of malignant transformation, signs and symptoms observed, changes in lifestyle, cessation of exposure to risk factors, uncertainties related to treatment, and the necessity for lifelong follow-up [ 8 , 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Clinical and Psychosocial Impact of Communication about Oral Potentially Malignant Disorders: A Scoping Review

Arboleda,

Pereira,

Epstein

et al. 2023

Dentistry Journal

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Delivering bad news has been widely studied in cancer, thus, this scoping review aims to identify the available evidence concerning the communication of oral potentially malignant disorders (OPMDs) and their clinical and psychosocial impacts. A search was performed using electronic databases (Medline/PubMed, Scopus, Embase, and Web of Science) and one grey literature database (Google Scholar). Studies focused on communicating the diagnosis of OPMDs and the patients’ perceptions were included. Study selection and data extraction were performed by two authors in a two-phase process. Five publications were included in the qualitative analysis. Differences regarding the study design, population, OPMDs assessed, and outcomes of professional–patient communication were found in each study. Protocols for OPMD communication have not yet been reported and there is a need to standardize strategies as communication skills may provide better clinical outcomes for patients diagnosed with potentially malignant disorders. Although future studies are needed, a brief list recommending the aspects that must be communicated is proposed.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Clinical and Psychosocial Impact of Communication about Oral Potentially Malignant Disorders: A Scoping Review

Arboleda,

Pereira,

Epstein

et al. 2023

Dentistry Journal

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“…In the development of OSCC, there is a group of diseases known as oral potentially malignant diseases (OPMDs), which are de ned as any oral mucosal abnormality associated with an increased risk of developing oral cancer [28]. Numerous studies have shown its association with an increased risk of OSCC development [29]. To investigate the early diagnostic level of IL1RA and its expression changes during the progression from OPMD to OSCC, we created a 4NQO mouse model that simulated the progression from normal oral mucosa to epithelial hyperplasia to atypical epithelial dysplasia/carcinoma in situ to squamous carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Low expression of interleukin-1 receptor antagonist correlate with poor prognosis via promoting proliferation and migration and inhibiting apoptosis in oral squamous cell carcinoma

Ding,

Yi,

Shan

et al. 2023

Preprint

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Background: Biomarkers are biochemical indicators that can identify changes in the structure or function of systems, organs, or cells and can be used to monitor a wide range of biological processes, including cancer. Interleukin-1 receptor antagonist (IL1RA) is an important inflammatory suppressor gene and tumor biomarker. The goal of this study was to investigate the expression of IL1RA, its probable carcinogenic activity, and its diagnostic targets in oral squamous cell carcinoma (OSCC). Results: We discovered that IL1RA was expressed at a low level in OSCC tumor tissues compared to normal epithelial tissues and that the expression declined gradually from epithelial hyperplasia through dysplasia to carcinoma in situ and invasive OSCC. Low IL1RA expression was associated not only with poor survival but also with various clinicopathological markers such as increased infiltration, recurrence, and fatalities. Following cellular phenotyping investigations in OSCC cells overexpressing IL1RA, we discovered that recovering IL1RA expression decreased OSCC cell proliferation, migration, and increased apoptosis. Conclusions: In summary, our investigation highlighted the possible involvement of low-expression IL1RA in OSCC cells in promoting invasive as well as metastatic and inhibiting apoptosis, as well as the efficacy of IL1RA-focused monitoring in the early detection and treatment of OSCC.

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“…5 The most common OPMDs are leukoplakia, erythroplakia, actinic cheilitis, oral submucous fibrosis (OSF), and oral lichen planus erosive type. 6 A meta-analysis reported that the global prevalence of OPMD is 4.47%, with a higher incidence in men. 3 The etiopathogenesis of OPMD is a complex multifactorial process involving various genetic and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

Analysis on the Knowledge about Oral Potentially Malignant Disorders of a Male Motorcycle Community in Indonesia

Ahmada,

Ramadhanti,

Surboyo

et al. 2023

Journal of Health and Allied Sciences NU

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Background Oral potentially malignant disorders (OPMDs) are a group of oral lesions or conditions with a higher risk of malignant transformation. OPMD affects 4.47% of people worldwide, with predilection in males. The high tendency of frequent tobacco smoking and alcohol consumption may lead the male motorcycle community to have a higher risk for developing OPMD and malignant transformation. Objectives This article determines the level of knowledge about OPMD within a male motorcycle community. Methods This study uses a survey research design that is a questionnaire-based and descriptive study. Data were obtained using a Google Form, and IBM SPSS was used for analysis. Simple random sampling is the sampling method applied. The total knowledge score is divided into three levels, low (0–4), moderate (5–9), and high (10–15). Results The questionnaire was finished by 60 people entirely. All respondents (100%) were men, and the majority (83.00%) was aged between 20 and 21. A total of 26 respondents (43.30%) had moderate knowledge levels, followed by 21 with high knowledge levels (35.0%), and 13 with low knowledge levels (21.70%). Conclusion The majority of the male motorcycle community (43.30%) has a moderate knowledge level regarding OPMD. This study indicates the need for educational measures to improve awareness regarding OPMD in a high-risk community.

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Quality of life among Oral Potentially Malignant Disorder (OPMD) patients: A prospective study

Cited by 6 publications

References 27 publications

Clinical and Psychosocial Impact of Communication about Oral Potentially Malignant Disorders: A Scoping Review

Clinical and Psychosocial Impact of Communication about Oral Potentially Malignant Disorders: A Scoping Review

Low expression of interleukin-1 receptor antagonist correlate with poor prognosis via promoting proliferation and migration and inhibiting apoptosis in oral squamous cell carcinoma

Analysis on the Knowledge about Oral Potentially Malignant Disorders of a Male Motorcycle Community in Indonesia

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