Quality of life among patients with autoimmune hepatitis in remission

Takahashi, Atsushi; Abe, Masanori; Yasunaka, Tetsuya; Arinaga‐Hino, Teruko; Abe, Kazumichi; Takaki, Akinobu; Torimura, Takuji; Zeniya, Mikio; Yoshizawea, Kaname; Kang, Jong Hon; Suzuki, Yoshiyuki; Nakamoto, Nobuhiro; Inui, Ayano; Tanaka, Atsushi; Takikawa, Hajime; Ohira, Hiromasa

doi:10.1097/md.0000000000022764

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…In the present study, no significant relationship was reported between alcohol, smoking and drug use and quality of life, similar to the results of other studies [33,34]. Takahashi et al [35] showed a relationship between alcohol consumption and reduced quality of life in patients with hepatitis C. Patients in that study not only suffered chronic alcoholism but also experienced social problems such as unemployment and family breakdown. The lack of significant difference might be due to the fact that most patients in these studies had previously stopped taking drugs for a long time.…”

Section: Resultssupporting

confidence: 91%

Relationship between Quality of Life and Oral Health Status of Patients with Chronic Liver Disease

Moslemi,

Jahanshahi,

Hashemipour

2023

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To investigate the relationship between the quality of life and work ability related to the oral health status of patients with chronic liver diseases. Material and Methods: The sample size contains all patients referred to the internal ward of Afzalipour and Bahonar hospitals due to chronic liver disease from 2019 to 2020. Patient selection was based on a simple census and a questionnaire that contained characteristics information of the patient, Work Ability Index questionnaire and SF-36 questionnaire were completed by the patients and some information was extracted from medical file. The SF-36 questionnaire assesses the quality of life in two general dimensions (physical health and mental health) with the physical function subscale. DMFT, Gingival index, and Periodontal disease index are used to evaluate the severity and extent of gingivitis and periodontitis. For data analysis, ANOVA, Spearman correlation coefficients were used and the significant level was p<0.05. Results: a total of 108 patients were examined. The mean age of participants was 41.2 ± 4.3 years. The DMFT index in patients was also reported as 22.6 ± 7.35. Also, 32.4% of people described their ability to do work as poor, 21.3% as good, and 7.4% as excellent. Patients with poor or moderate workability reported a higher index of DMFT. Among the participants, 61 and 21 patients had gingivitis and periodontitis, respectively. Mean results of total SF-36 indices were reported at a low level in patients with increased DMFT and gum diseases. Patients with poor or moderate workability had a higher index of DMFT. There was a significant relationship between these two variables (p=0.001). However, they were not significantly associated with periodontitis. Conclusion: There was a significant relationship between the SF-36 index, the ability to work and the type of liver disease.

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Section: Resultssupporting

confidence: 91%

Relationship between Quality of Life and Oral Health Status of Patients with Chronic Liver Disease

Moslemi,

Jahanshahi,

Hashemipour

2023

Pesqui. Bras. Odontopediatria Clín. Integr.

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“…Despite this progress, a clear need still exists for better treatment options and expanded endpoints in every aspect of autoimmune hepatitis 71. First line and second line treatments are characterized by several mostly dosage dependent side effects that may greatly affect quality of life, even when biochemical and histological remission are reached 7273. This has a particular impact on children and adolescents, whose adherence to treatment is often lower 49.…”

Section: Quality Of Lifementioning

confidence: 99%

Diagnosis and management of autoimmune hepatitis

Muratori

Lohse

Lenzi

2023

BMJ

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Autoimmune hepatitis is an inflammatory disease of the liver of unknown cause that may progress to liver cirrhosis and end stage liver failure if diagnosis is overlooked and treatment delayed. The clinical presentation is often that of acute hepatitis, sometimes very severe; less frequently, it can be insidious or completely asymptomatic. The disease can affect people of any age and is more common in women; its incidence and prevalence seem to be on the rise worldwide. An abnormal immune response targeting liver autoantigens and inducing persistent and self-perpetuating liver inflammation is the pathogenic mechanism of the disease. A specific set of autoantibodies, increased IgG concentrations, and histological demonstration of interface hepatitis and periportal necrosis are the diagnostic hallmarks of autoimmune hepatitis. Prompt response to treatment with corticosteroids and other immunomodulatory drugs is almost universal and supports the diagnosis. The aims of treatment are to induce and maintain long term remission of liver inflammation. Treatment can often even reverse liver fibrosis, thus preventing progression to advanced cirrhosis and its complications. Most patients need lifelong maintenance therapy, and repeated follow-up in experienced hands improves the quality of care and quality of life for affected patients.

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“…In Japan, it was also reported that patients with AIH had an impaired health-related QOL and that doctors should be aware of the risk when prescribing steroids ( 17 ). In addition, Takahashi et al demonstrated that even patients with AIH in remission showed an impaired health-related QOL associated with disease duration ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Zinc Supplementation and an Improved Quality of Life in Patients with Autoimmune Hepatitis

et al. 2024

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Objecive Patients with autoimmune hepatitis (AIH) reportedly have an impaired quality of life (QOL), mainly due to depression, even during remission. In addition, hypozincaemia has been demonstrated in patients with chronic liver disease, including AIH, and is known to be related to depression. Corticosteroids are known to cause mental instability. We therefore investigated the longitudinal association between zinc supplementation and changes in the mental status among AIH patients treated with corticosteroids. Materials This study enrolled 26 patients with serological remission of AIH routinely treated at our facility after excluding 15 patients who either discontinued polaprezinc (150 mg/day) within 24 months or interrupted treatment. Two questionnaires, the Chronic Liver Disease Questionnaire (CLDQ) and SF-36, were adopted to evaluate the QOL before and after zinc supplementation. Results Serum zinc levels were significantly elevated after zinc supplementation (p＜0.0001). The CLDQ worry subscale significantly improved after zinc supplementation (p=0.017), but none of the SF-36 subscales was affected. Multivariate analyses demonstrated that daily prednisolone dosing was inversely related to both the CLDQ worry domain score (p=0.036) and the SF-36 mental health component (p=0.031). There was a significant negative correlation between the changes in the daily steroid dose and the CLDQ worry domain scores before and after zinc supplementation (p=0.006). No serious adverse events occurred during the observation period. Conclusion Zinc supplementation safely and efficiently improved mental impairment, possibly caused by continuous treatment with corticosteroids, in patients with AIH.

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Quality of life among patients with autoimmune hepatitis in remission

Cited by 6 publications

References 28 publications

Relationship between Quality of Life and Oral Health Status of Patients with Chronic Liver Disease

Relationship between Quality of Life and Oral Health Status of Patients with Chronic Liver Disease

Diagnosis and management of autoimmune hepatitis

Zinc Supplementation and an Improved Quality of Life in Patients with Autoimmune Hepatitis

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