Quality of life and associated factors in patients with chronic Chagas disease

Santos-Filho, João C L; Vieira, Marcelo Carvalho; Xavier, Isis Gabrielli Gomes; Maciel, Erica Rodrigues; Júnior, Luiz Fernando Rodrigues; Curvo, Eduardo Ov; Pereira, Iane M; Quintana, Marcel de Souza Borges; Silva, Gilberto M Sperandio da; Veloso, Henrique Horta; Mendes, Fernanda S.N.S.; Hasslocher‐Moreno, Alejandro Marcel; Sousa, Andréa Silvestre de; Brasil, Pedro Emmanuel Alvarenga Americano do; Saraiva, Roberto Magalhães; Mediano, Mauro Felippe Felix

doi:10.1111/tmi.13144

Cited by 17 publications

(31 citation statements)

References 30 publications

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“…We also found that female sex, body mass index, functional performance, physical status, and mental health were associated with depressive symptoms. Previous studies 36,37 have already shown a higher prevalence of depressive symptoms in women with ChC when compared to men, which has also been observed in other populations 38,39 . Sex differences in biological, psychological, and environmental factors, as well as many hormonal changes caused by the menstrual cycle, pregnancy, postpartum period, abortion, and menopause may explain the association of the female sex with depressive symptoms 40 .…”

Section: /7supporting

confidence: 66%

Prevalence and determinants of depressive symptoms in patients with Chagas cardiomyopathy and predominantly preserved cardiac function

Silva

Ávila

Oliveira

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Chagas cardiomyopathy (ChC) is highly stigmatized, and the presence of depressive symptoms may be a common feature. However, its determinants remain unclear. Therefore, the present study aimed to verify the prevalence of depression and the clinical, echocardiographic, functional, and quality of life factors associated with depressive symptoms in patients with ChC and predominantly preserved cardiac function. Methods: Thirty-five patients with ChC (aged 40 to 60 years, 66% men, NYHA I-III) were evaluated by echocardiography, cardiopulmonary exercise testing, 6-minute walk test (6MWT), and Mini-Mental State Examination. Physical activity level was assessed using the Human Activity Profile (HAP) and health-related quality of life was assessed using the Short-Form Health Survey (SF-36). Depressive symptoms were evaluated using the Beck Depression Inventory. A cutoff point greater than 9 was indicative of depression. Results: Depression was detected in 13 patients (37%). In the univariate analysis, female sex, NYHA functional class, body mass index, HAP score, mental summary of SF-36, peak oxygen uptake, and 6MWT distance were associated with depressive symptoms. The final model showed that only the HAP score (B =-0.533; 95% confidence interval [CI]:-0.804 to-0.262) and SF-36 mental summary (B =-0.269; 95% CI:-0.386 to-0.153) remained as independent predictors of depressive symptoms in patients with ChC. Conclusions: Depression was prevalent in patients with ChC and predominantly preserved cardiac function. Physical activity and mental health were independent risk factors for depressive symptoms.

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Section: /7supporting

confidence: 66%

Prevalence and determinants of depressive symptoms in patients with Chagas cardiomyopathy and predominantly preserved cardiac function

Silva

Ávila

Oliveira

et al. 2020

Rev. Soc. Bras. Med. Trop.

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“…Quality of life is also worse in patients with HF due to ChD than other aetiologies . Functional class and ChD clinical presentation are independently associated with quality of life in patients with ChD …”

Section: Introductionmentioning

confidence: 99%

Impact of pharmaceutical care on the quality of life of patients with heart failure due to chronic Chagas disease: Randomized clinical trial

Chambela

Mediano

Carneiro

et al. 2019

Brit J Clinical Pharma

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Aims: Chronic Chagas disease (ChD) has high morbimortality and loss in quality of life due to heart failure (HF). Pharmaceutical care (PC) optimizes clinical treatment and can improve quality of life in HF. We evaluated if PC improves quality of life of patients with ChD and HF.Methods: Single-blinded, randomized, controlled trial that assigned adult patients with ChD and HF (81 patients; 61 ± 11 years; 48% male) to PC (n = 40) or standard care (n = 41). Quality of life according to SF-36 and Minnesota living with HF questionnaires, incidence of drug-related problems (DRPs), and adherence to medical treatment were determined at baseline and at every 3 months for 1 year. Intentionto-treat analyses were performed by mixed linear model to verify the treatment effect on the changes of these variables throughout the intervention period.Results: Relative changes from baseline to 1 year of follow-up of the domains physical functioning (+16.6 vs -8.5; P < .001), role-physical (+34.0 vs +5.2; P = .01), general health (+19.4 vs -6.1; P < .001), vitality (+11.5 vs. -5.8; P = .003), social functioning (+7.5 vs -13.3; P = .002), and mental health (+9.0 vs -3.7; P = .006) of the SF-36 questionnaire and the Minnesota living with HF questionnaire score (−12.7 vs +4.8; P < .001) were superior in the PC group than in the standard care group. Adherence to medical treatment increased as early as after 3 months of follow-up and DRPs incidence decreased after 6 months of follow-up only in the PC group.Conclusions: Patients with ChD and HF who received PC presented improved quality of life, decrease in DRP frequency, and increase in medication adherence.

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“…Most of the articles involved patients with Chagas cardiomyopathy with HF. Only two studies stratified the clinical form of CD 11 , 25 ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…All studies with the WHOQoL-Bref instrument used a sectional study design 11 , 25 , 39 , 40 . When calculating the mean of the Physical, Psychological, Social Relations and Environment domains, the results were 59.5, 62.8, 67.3, and 55.4, respectively.…”

Section: Resultsmentioning

confidence: 99%

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Quality of life in patients with Chagas disease and the instrument used: an integrative review

Baldoni

Quintino

Alves

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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Chagas disease (CD) is a neglected tropical highly morbid disease that can have a negative impact on the quality of life (QoL). The purpose of this study was to conduct an integrative review to analyze the QoL of patients with CD in the chronic phase of the disease, as well as the instruments used and the effect of different interventions. The review was carried out based on the criteria and recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guideline (PRISMA) using the PubMed, Scopus, Web of Science and Science Direct databases. An analysis of the reference list of the included articles was also carried out. Publications in all languages have been included. Two independent reviewers selected the eligible articles and extracted the data. A total of 1,479 articles were identified, and after applying the inclusion criteria 18 articles were included. Four different instruments were used to assess QoL and the most used was the Minnesota Living with Heart Failure Questionnaire (MLWHFQ) [33.3% (n = 6)]. Investigations involving intervention showed a positive impact on the patients’ QoL, and the Environment domain had the lowest score. Heterogeneity of instruments and lack of methodology standardization for assessing QoL was observed. QoL proved to be an important indicator for the planning and monitoring of patients with CD, however it is suggested that the instruments for its assessment should be the ones recommended by the validation studies. This process will allow the comparison of data between investigations.

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Quality of life and associated factors in patients with chronic Chagas disease

Cited by 17 publications

References 30 publications

Prevalence and determinants of depressive symptoms in patients with Chagas cardiomyopathy and predominantly preserved cardiac function

Prevalence and determinants of depressive symptoms in patients with Chagas cardiomyopathy and predominantly preserved cardiac function

Impact of pharmaceutical care on the quality of life of patients with heart failure due to chronic Chagas disease: Randomized clinical trial

Quality of life in patients with Chagas disease and the instrument used: an integrative review

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