Quality‐of‐life and asthma‐severity in general population asthmatics: results of the ECRHS II study

Siroux, Valérie; Boudier, Anne; Antó, Josep M.; Cazzoletti, Lucia; Accordini, Simone; Alonso, Jordi; Cerveri, Isa; Corsico, Angelo Guido; Gulsvik, Amund; Jarvis, Déborah; Marco, Roberto de; Marcon, Alessandro; Marques, Elisa A.; Bugiani, Massimiliano; Janson, Christer; Leynaert, Bénédicte; Pin, Isabelle

doi:10.1111/j.1398-9995.2008.01638.x

Cited by 90 publications

(75 citation statements)

References 32 publications

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“…The AQLQ score in participants with asthma and no insomnia were similar to the score found in a population-based study of 864 adults with asthma. 33 The presence of insomnia in patients with asthma may lead to more severe depression and anxiety symptoms and further reductions in quality of life.…”

Section: Discussionmentioning

confidence: 99%

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

Luyster

Strollo

Holguin

et al. 2016

Chest

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BACKGROUND: Sleep difficulties are commonly reported by patients with asthma; however, the prevalence of insomnia and its association with disease burden and well-being is unknown. We aimed to determine the prevalence of insomnia, defined as combined sleep-specific complaints with associated daytime symptoms, among a large sample of adults with asthma, and to compare well-being, asthma control, and asthma-related health care utilization in individuals with asthma and insomnia and those without insomnia.

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Section: Discussionmentioning

confidence: 99%

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

Luyster

Strollo

Holguin

et al. 2016

Chest

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“…Many studies have shown that HRQoL in asthma is correlated with asthma severity to some extent [21,22]. Nevertheless, differences in HRQoL in asthma cannot be fully explained by asthma severity or any of the other traditional treatment outcome measures, which is why this measure is interesting: it captures some aspects of treatment outcome that cannot otherwise be measured.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Generalist and Specialist Care on Quality of Life in Asthma Patients with and without Allergic Rhinitis

Harmsen

Nolte²,

Backer³

2010

Int Arch Allergy Immunol

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Background: Treatment of asthma and rhinitis patients is often provided by both generalists (GPs) and specialists (SPs). Studies have shown differences in clinical outcomes of treatment between these settings. The aim of this study was to evaluate the effect of GP and SP care on health-related quality of life (HRQoL). Materials and Methods: Three hundred and eight asthma and allergic rhinitis patients randomized to 3 years’ treatment by an SP or GP were examined at baseline and at study completion. At both examinations, the HRQoL was measured with the Standardized Asthma Quality of Life Questionnaire (AQLQ) and the Rhinitis Quality of Life Questionnaire (RQLQ). Results: In the SP care, a significant improvement from baseline was found in HRQoL for both AQLQ total scores (6.19 ± 0.1 vs. 6.44 ± 0.1, respectively; p < 0.001) and RQLQ total scores (0.80 ± 0.1 vs. 0.58 ± 0.1, respectively; p <0.01). Patients in the GP care setting experienced no change in HRQoL total scores during the study. However, improvements were found predominantly in patients with concomitant rhinitis. Although no change in AQLQ was found in the GP setting in this group with double disease, an association between change in RQLQ and AQLQ was found (r = –0.245, p < 0.05, and r = –0.324, p < 0.001, respectively). Conclusion: The results provide evidence that compared with GP care, SP care leads to an improvement in both asthma and rhinitis quality of life. This is especially pronounced in patients with concomitant asthma and rhinitis and supports the guidelines recommending that SPs should monitor patients with complicated disease.

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“…An important goal of asthma management strategies is to improve health-related quality of life (25,26). The AQLQ is a validated tool for assessing the impact of asthma and evaluating outcomes of various therapies (27).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma

Castro

Rubin

Laviolette

et al. 2010

Am J Respir Crit Care Med

628

289

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Rationale: Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle. Objectives: To evaluate the effectiveness and safety of BT versus a sham procedure in subjects with severe asthma who remain symptomatic despite treatment with high-dose inhaled corticosteroids and long-acting b 2 -agonists. Methods: A total of 288 adult subjects (Intent-to-Treat [ITT]) randomized to BT or sham control underwent three bronchoscopy procedures. Primary outcome was the difference in Asthma Quality of Life Questionnaire (AQLQ) scores from baseline to average of 6, 9, and 12 months (integrated AQLQ). Adverse events and health care use were collected to assess safety. Statistical design and analysis of the primary endpoint was Bayesian. Target posterior probability of superiority (PPS) of BT over sham was 95%, except for the primary endpoint (96.4%). Measurements and Main Results:The improvement from baseline in the integrated AQLQ score was superior in the BT group compared with sham (BT, 1.35 6 1.10; sham, 1.16 6 1.23 [PPS, 96.0% ITT and 97.9% per protocol]). Seventy-nine percent of BT and 64% of sham subjects achieved changes in AQLQ of 0.5 or greater (PPS, 99.6%). Six percent more BT subjects were hospitalized in the treatment period (up to 6 wk after BT). In the posttreatment period (6-52 wk after BT), the BT group experienced fewer severe exacerbations, emergency department (ED) visits, and days missed from work/ school compared with the sham group (PPS, 95.5, 99.9, and 99.3%, respectively).Conclusions: BT in subjects with severe asthma improves asthmaspecific quality of life with a reduction in severe exacerbations and healthcare use in the posttreatment period. Clinical trial registered with www.clinialtrials.gov (NCT00231114).Keywords: asthma; Alair Bronchial Thermoplasty System; bronchial thermoplasty; bronchoscopic procedure; Asthma Quality of Life Bronchial thermoplasty (BT) is a novel intervention for asthma that delivers controlled thermal energy to the airway wall during a series of bronchoscopy procedures, resulting in a prolonged reduction in airway smooth muscle (ASM) mass (1, 2). Increased mass and contractility of ASM augments asthma morbidity by causing greater bronchoconstriction and airflow obstruction (3). Decreasing the amount and/or contractility of ASM may provide a means to ameliorate the symptoms of asthma.Previous clinical trials of BT were nonrandomized (4) or randomized to include a standard of care control group (5, 6). In these initial studies, BT was associated with a decrease in the AT A GLANCE COMMENTARY Scientific Knowledge on the Subject Bronchial thermoplasty is a novel intervention for asthma that delivers controlled thermal energy to the airway wall during a series of bronchoscopy procedures. What This Study Adds to the FieldThe current study reflects one of the largest shamcontrolled trials in pulmonary medicine to test a novel device to perform bronchial thermoplasty, a procedure for the treatment of ...

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Quality‐of‐life and asthma‐severity in general population asthmatics: results of the ECRHS II study

Abstract: In population-based asthmatics, the specific AQLQ questionnaire, and also to a lesser extent the generic SF-36 questionnaire, were sensitive to asthma-severity. Frequencies of asthma attacks, of nocturnal symptoms and hospitalization for asthma have independent impact on HRQL.

Cited by 90 publications

References 32 publications

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

Association Between Insomnia and Asthma Burden in the Severe Asthma Research Program (SARP) III

The Effect of Generalist and Specialist Care on Quality of Life in Asthma Patients with and without Allergic Rhinitis

Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma

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