Quality of life and calcium channel blockade with nifedipine GITS versus amlodipine in hypertensive patients in Spain

Testa, Marcia A.; Turner, Ralph R.; Simonson, Donald C.; Krafcik, Mary Beth; Calvo, Carlos; Luque-Otero, M.

doi:10.1097/00004872-199816120-00018

Cited by 38 publications

(25 citation statements)

References 29 publications

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“…Long-term treatment with nitrendipine alone or in combination with an ACEI or a diuretic reduces the incidence of an Alzheimer-type dementia by about 50% (1). Very recently, similar effects have been reported by treatment with amlodipine (21). Blood pressure reduction per se contributes to the prevention of dementia in hypertension.…”

Section: Discussionsupporting

confidence: 69%

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

et al. 2003

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Among the consequences of the increasing prolongation of lifespan is a worldwide increase in the number of cases of dementia or impaired cognition. In the present study, to test the hypothesis that mechanisms independent of high blood pressure are involved in maintaining cognitive function, we assessed the effects of long-term dilazep treatment on cognitive dysfunction in normotensive Dahl salt-sensitive (Dahl S) rats fed a low-salt diet, using the standard passive avoidance test. Normotensive Dahl S rats fed a 0.3% NaCl diet were treated for 6 months with low-dose dilazep (2.5 g/ml in drinking water) or high-dose dilazep (12.5 g/ml).

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Section: Discussionsupporting

confidence: 69%

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

et al. 2003

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“…[28][29][30][31][32] Contrasting results have also been reported with diuretics 16,28,30 and calcium antagonists. 17,29,[32][33][34] Only antihypertensive drugs that interfere with the renin-angiotensin system seem to be effective in preventing cognitive decline and even improving cognitive function in hypertensive patients. Thus, in both experimental and clinical studies ACE inhibitors and the more recent Angiotensin II (AngII) antagonists have been shown to influence mental function positively, improving learning and memory.…”

Section: Introductionmentioning

confidence: 99%

Influence of losartan and atenolol on memory function in very elderly hypertensive patients

et al. 2003

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The aim of this study was to compare the effect of the beta-adrenergic blocker atenolol and the Angiotensin II type 1 (AT1) receptor antagonist losartan on cognitive function in very elderly hypertensive patients. A total of 120 mild to moderate essential hypertensive (DBP 490 and o105 mmHg) patients, aged 75-89 years, were studied. After a 4-week wash-out period on placebo, they were randomized to receive atenolol 50 mg or losartan 50 mg for 24 weeks according to a parallel arm design. At the end of the placebo period and of each active treatment period, BP was measured (by mercury sphygmomanometer, Korotkoff I and V) and cognitive function was evaluated through three different tests (word list memory, word list recall and word list fluency). Both atenolol and losartan were equally effective in reducing SBP (À22.1 and À23.1 mmHg, respectively, Po 0.01 vs baseline) and DBP (À10.3 and À11.2 mmHg, respectively, Po 0.01 vs baseline). Atenolol treatment did not induce significant changes in any test score, whereas losartan significantly increased the score of both the word list memory (+2.2, Po0.05 vs baseline) and the word list recall test (+2.1, Po0.05 vs baseline). The comparison between losartan and atenolol was significant (Po0.05) for both memory tests. These data suggest that in very elderly hypertensive patients, chronic AT1 receptor blockade by losartan could improve cognitive function, in particular immediate and delayed memory.

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“…36 Because AML sub- NIF vs. AML and arterial stiffness M Fukuda et al stantially inhibits Ca channel activity for a long period, it is possible that long-term AML treatment could lead to excessive suppression of vascular compliance so that the vessels no longer respond properly to autonomic regulation. Testa and colleagues 37 found that AML treatment had a negative influence on perceived general health, vitality and sleep compared with nifedipine GITS when they surveyed healthrelated quality of life in hypertensive patients. The controlled-release preparation used in this study maintains an adequate plasma concentration of nifedipine, 38 which presumably results in appropriate autonomic regulation of the cardiovascular system.…”

Section: Discussionmentioning

confidence: 99%

Influence of nifedipine coat-core and amlodipine on systemic arterial stiffness modulated by sympathetic and parasympathetic activity in hypertensive patients

et al. 2009

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The aim of this study was to compare the effects of nifedipine coat-core (once daily formulation) and amlodipine on systemic arterial stiffness in patients with hypertension. Study drugs were assigned by the randomized open-label crossover method. After the blood pressure was maintained below 130/85 mm Hg for 8 months by treatment with either drug in 48 hypertensive patients (aged 63.2±6.9 years; 64.5% men), they were switched to the other drug for another 8 months. The blood pressure, heart rate, plasma catecholamine level and brachial-ankle pulse wave velocity were measured before and after a bicycle ergometer testing. Heart rate recovery was calculated from the change of the heart rate after treadmill exercise testing. The high-frequency and low-frequency components of the heart rate variability spectrum were analyzed from 24-h Holter electrocardiograms. The change of blood pressure after exercise testing showed no significant difference between the two medications. However, the increases of heart rate, noradrenalin and branchial-ankle pulse wave velocity after exercise were significantly smaller with nifedipine treatment than with amlodipine (P¼0.0472, P¼0.006 and P¼0.0472, respectively). Heart rate recovery was significantly faster with nifedipine treatment (P¼0.0280). The nighttime high-frequency component of heart rate variability was significantly larger after nifedipine treatment than after amlodipine (P¼0.0259), while the nighttime low/high-frequency ratio was significantly smaller with nifedipine (P¼0.0429). Nifedipine reduced functional arterial stiffness and improved heart rate recovery by altering the autonomic activity balance in hypertensive patients.

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Quality of life and calcium channel blockade with nifedipine GITS versus amlodipine in hypertensive patients in Spain

Cited by 38 publications

References 29 publications

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

Effects of the Anti-Platelet Aggregation Drug Dilazep on Cognitive Function in Dahl Salt-Sensitive Rats.

Influence of losartan and atenolol on memory function in very elderly hypertensive patients

Influence of nifedipine coat-core and amlodipine on systemic arterial stiffness modulated by sympathetic and parasympathetic activity in hypertensive patients

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