Quality of life and chronic health conditions in childhood acute leukaemia survivors

Aznar, Elena Guadalupe Corella; Casas, A. Ayerza; Bañeres, Ana Carboné; Escribano, María Ángeles Carlota Calvo; Aizpún, José Ignacio Labarta; Villagrasa, Pilar Samper

doi:10.1016/j.medcle.2019.01.004

Cited by 7 publications

(28 citation statements)

References 29 publications

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“…Three studies found no significant differences in perceived QoL 30,36,50 and five studies found that survivors rated QoL or subscales higher than a comparison group. 19,40,42,43,45 Of the 23 studies that found a lower QoL in survivors, 12 were based on survivors of various cancers, [20][21][22][23][24][25]28,[31][32][33][34][35] six on survivors of haematological cancers, [37][38][39]44,46,48 three on brain tumour survivors, 49,51,52 one on survivors of differentiated thyroid carcinoma 53 and one on survivors of head-and-neck rhabdomyosarcoma. 54 The five studies that found a higher QoL in survivors were based mainly on survivors of haematological cancers.…”

Section: Quality Of Lifementioning

confidence: 99%

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Larsen

Amidi

Ghith

et al. 2023

Intl Journal of Cancer

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Advances in diagnostics and treatment of childhood cancer during the past few decades have substantially increased survival, resulting in a growing population of survivors of childhood cancer. Somatic and mental late effects of the cancer and the treatment may impact the quality of life (QoL). Previous reviews of QoL in survivors of childhood cancer have shown contradictory findings across studies and the majority of studies included have been based on data from North America and may not be directly comparable to a European setting. The aim of our study was to critically evaluate and summarise the latest evidence on the QoL of childhood cancer survivors in Europe and to identify survivors at particular risk. The eligible studies were published between 2008 and 2022, conducted in Europe and included participants who had survived at least 5 years after diagnosis of a childhood cancer. The main outcome of interest was QoL of survivors which was measured with validated qualitative and quantitative QoL questionnaires. A systematic literature search conducted in PubMed, EMBASE, PsycINFO and CINALH resulted in inclusion of 36 articles with a total of 14 342 survivors of childhood cancer. The majority of included studies found that childhood cancer survivors reported poorer QoL than comparisons. Female gender, treatment with haematopoietic stem cell transplantation and a brain tumour diagnosis were associated with lower QoL. With a growing population of childhood cancer survivors with many years ahead of them, targeted interventions and optimal follow‐up care are important to improve the QoL of survivors.

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Section: Quality Of Lifementioning

confidence: 99%

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Larsen

Amidi

Ghith

et al. 2023

Intl Journal of Cancer

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“…HSCT recipients are at high risk of late effects ( 212 – 216 ); a recent study on survivors of haematological malignancies found that 47% of HSCT recipients and 22% of patients who received only chemotherapy suffered from multiple chronic health conditions 10–33 years post diagnosis ( 215 ). The presence of a chronic health conditions is the strongest predictor of reduced HRQoL in leukaemia survivors ( 212 , 214 – 216 ). Indeed, the number of chronic health conditions seems to have a greater impact on the long-term HRQoL than the treatment modality the patient received (HSCT vs. chemotherapy only) ( 215 ).…”

Section: Long-term Neurotoxicity Post Hsctmentioning

confidence: 99%

A Review of Acute and Long-Term Neurological Complications Following Haematopoietic Stem Cell Transplant for Paediatric Acute Lymphoblastic Leukaemia

et al. 2021

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Despite advances in haematopoietic stem cell transplant (HSCT) techniques, the risk of serious side effects and complications still exists. Neurological complications, both acute and long term, are common following HSCT and contribute to significant morbidity and mortality. The aetiology of neurotoxicity includes infections and a wide variety of non-infectious causes such as drug toxicities, metabolic abnormalities, irradiation, vascular and immunologic events and the leukaemia itself. The majority of the literature on this subject is focussed on adults. The impact of the combination of neurotoxic drugs given before and during HSCT, radiotherapy and neurological complications on the developing and vulnerable paediatric and adolescent brain remains unclear. Moreover, the age-related sensitivity of the nervous system to toxic insults is still being investigated. In this article, we review current evidence regarding neurotoxicity following HSCT for acute lymphoblastic leukaemia in childhood. We focus on acute and long-term impacts. Understanding the aetiology and long-term sequelae of neurological complications in children is particularly important in the current era of immunotherapy for acute lymphoblastic leukaemia (such as chimeric antigen receptor T cells and bi-specific T-cell engager antibodies), which have well-known and common neurological side effects and may represent a future treatment modality for at least a fraction of HSCT-recipients.

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“…Didalam konsep tersebut terdapat beberapa dimensi yaitu: kesehatan fisik dan psikologis, hubungan sosial dan lingkungannya. Sedangkan kualitas hidup yang berhubungan dengan kesehatan adalah jarak antara objektif dengan subjektif dari individu, hal tersebut berasal dari rasa emosional, aktivitas sosial, hubungan kekerabatan, kepuasan, cita-cita, dan kepuasan untuk menjalani hidupnya (Corella Aznar et al, 2019).…”

Section: Pembahasanunclassified

Literatur Review : Kualitas Hidup Pasien Leukemia

2020

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Leukemia is a malignant disease that attacks the hematopoiesis system, causing uncontrolled blood cell proliferation. Quality of life is one indicator that can be used to see the welfare conditions of patients suffering from chronic diseases such as leukemia. This review literature aims to find out the factors that influence the quality of life of leukemia patients. Literature search through Google Scholar, EBSCO, Springer Link, Elsevier, Sage databases using keywords: factors, quality of life, leukemia. The journals taken have a range from 2018 to 2020, which are then filtered according to the inclusion criteria set by the author. The results of the review indicate that there are several factors that affect the quality of life in leukemia patients, namely the therapeutic treatment undertaken, the patient's environment, and the role of care giver. Proper management of leukemia patients will improve the quality of life of these patients, and vice versa.

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Quality of life and chronic health conditions in childhood acute leukaemia survivors

Cited by 7 publications

References 29 publications

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

Quality of life of adolescent and adult survivors of childhood cancer in Europe—A systematic review

A Review of Acute and Long-Term Neurological Complications Following Haematopoietic Stem Cell Transplant for Paediatric Acute Lymphoblastic Leukaemia

Literatur Review : Kualitas Hidup Pasien Leukemia

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