Quality of life and clinical outcomes in bipolar disorder: An 8-year longitudinal study

Khafif, Tatiana Cohab; Belizário, Gabriel Okawa; Silva, Michelle; Gomes, Bernardo Carramão; Lafer, Beny

doi:10.1016/j.jad.2020.09.061

Cited by 18 publications

(9 citation statements)

References 26 publications

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“…Additionally, in the MDD group, there was negative relationship between the physical domain and, the number of depressive episodes and suicidal behavior. These results are in consistent with the literatüre (22,28,34). Although treatment goals are centered around the reduction of depressive symptoms in most clinical settings, remission does not denote normal QOL in depressed patients (11).…”

Section: Discussionsupporting

confidence: 86%

“…That results suggest that previous depressive episodes, may have a greater impact on patients' perceived QOL, even if they are euthymic. In a follow-up study, in which bipolar patients were evaluated in terms of QOL, it was reported that one of the most effective factors on QOL was the number of depressive episodes (28). A study made in our country to evaluate the QOL of depressive patients demonstrated that patients who had a relapsing type depressive disorder had lower QOL in terms of physical functionality and general health perception than patients who had depression in a single period (29).…”

Section: Discussionmentioning

confidence: 96%

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Poor quality of life and functioning in euthymic mood disorders

Harmanci

Yörübulut

2022

Anatolian Current Medical Journal

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Aim: This study’s aim is to examine the relationship between clinical/demographic characteristics the quality of life (QOL) and functionality in patients with mood disorders. Material and Method: Total of 280 participants, including participants with bipolar disorder I (BD I), bipolar disorder II (BD II) major depressive disorder (MDD) in remission, and healty control subjects (HC), were included. Beck Depression Inventory (BDI), World Health Organization Quality of Life Instrument Short Form Scale (WHOQOL-BREF), Beck Anxiety Inventory (BAI), Young Mania Rating Scale (YMRS), and General Functioning Assessment Scale (GAF) were used. The data were evaluated with the SPSS 25.0 statistical program. Results: Compared with HC, patients with MDD had the lowest scores in the QOL total and subdomain scores (p=.001). There was a significant negative correlation between the QOL scores and the BDI scores, but there was a positive correlation between the educational level and the total QOL and social, enviromental domain scores. There was a significant negative correlation between the total QOL and physical domain and the number of depressive episodes. There was a significant negative correlation between the social domain and the number of hospitalizations, but there was a significant positive correlation between the physical, enviromental domain scores and the age of first episode. Conclusion: QOL between MDD is lower than that of BD. Educational level, number of depressive episodes and hospitalizations, suicide attemps, age of first episode, and BDI scores correlated with QOL. Additionally, it was determined that the main factor affecting the QOL was residual depressive symptoms rather than type of mood disorder.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 96%

Poor quality of life and functioning in euthymic mood disorders

Harmanci

Yörübulut

2022

Anatolian Current Medical Journal

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“…Even mild depressive symptoms can cause social dysfunction in patients with bipolar Maruki et al International Journal of Bipolar Disorders (2022) 10:24 depression (Kauer-Sant' Anna et al 2009). Furthermore, bipolar depression is associated with a lower quality of life (QOL) and poorer cognitive performance (Khafif et al 2021;Matsuo et al 2021). Therefore, the improvement of the symptoms of patients with bipolar depression is important for both patients and society.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of adjunctive therapy to lamotrigine, lithium, or valproate monotherapy in bipolar depression: a systematic review and meta-analysis of randomized controlled trials

Maruki

Utsumi

Takeshima

et al. 2022

Int J Bipolar Disord

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Background The efficacy and safety of adjunctive therapy are unclear in bipolar depression. In this systematic review and meta-analysis, we aimed to evaluate the efficacy and safety of second-generation antipsychotic, lamotrigine, lithium, or valproate therapy used in adjunction with lamotrigine, lithium, or valproate monotherapy in bipolar depression. A literature search of major electronic databases was conducted in February 2021, and all articles published until then were eligible. Two researchers independently screened relevant publications, extracted data, and evaluated methodological quality according to the Cochrane criteria. Results Five studies met the inclusion criteria. The meta-analysis revealed significant differences in the following outcomes: (i) remission rates from depressive episodes (risk ratio [RR]: 1.23, 95% confidence interval [CI] 1.01–1.50, p = 0.04), (ii) improvement in depressive symptoms (standardized mean difference [SMD]: 0.21, 95% CI 0.09–0.34, p = 0.001), (iii) improvement in quality of life (SMD: 0.22, 95% CI 0.06–0.37, p = 0.005), and (iv) rate of adverse events during the study period (RR: 1.12, 95% CI 1.03–1.22, p = 0.008). There was no significant difference between adjunctive therapy and monotherapy in the emergence of suicide-related behaviors, dropout rate during the study period, or rate of manic switching. Conclusions Our results suggest that adjunctive second-generation antipsychotics, lamotrigine, lithium, or valproate increase both the benefits and risks in patients with bipolar depression, although there is no significant difference in severe adverse events. Adjunctive therapy should be provided through shared decision-making while considering the patients’ condition in clinical settings.

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“…Here, we focus on how such variables may inform the course of manic symptoms, including onset, severity, and recurrence of manic or hypomanic episodes. Notwithstanding that depression is common among those with bipolar disorder [ 2 ] and is important for quality of life and functional outcomes within bipolar disorder [ 3 , 4 ], we focus here on mania for a few reasons. First, manic symptoms are the defining feature of bipolar spectrum disorders.…”

Section: Introductionmentioning

confidence: 99%

Social and environmental variables as predictors of mania: a review of longitudinal research findings

Johnson

Weinberg

2022

Discov Ment Health

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Considerable evidence suggests that psychosocial variables can shape the course of bipolar disorder. Here, though, we focus on the more specific idea that the social environment can predict the course of mania. We systematically review evidence from longitudinal studies concerning how social support, family interactions, traumatic life events, and recent life events relate to the age of onset, the frequency of episode recurrence, and the severity of manic symptoms. Although we find some evidence that the course of mania can be worsened by social environmental factors, the links are specific. Among social variables, some studies indicate that conflict and hostility are predictive, but more general social relationship qualities have not been found to predict mania. Some research indicates that childhood trauma, and recent life events involving goal attainment or sleep disruption can predict mania. Taken together, the profile of variables involving recent exposure that are most predictive include those that are activating, reward-related, or sleep-disrupting, which fits with general psychological hypotheses of behavioral activation and sleep disruption as important for mania. We discuss gaps in the literature, and we note future directions for research, including the need for more integrative, longitudinal research on a fuller range of social and biological risk variables.

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Quality of life and clinical outcomes in bipolar disorder: An 8-year longitudinal study

Cited by 18 publications

References 26 publications

Poor quality of life and functioning in euthymic mood disorders

Poor quality of life and functioning in euthymic mood disorders

Efficacy and safety of adjunctive therapy to lamotrigine, lithium, or valproate monotherapy in bipolar depression: a systematic review and meta-analysis of randomized controlled trials

Social and environmental variables as predictors of mania: a review of longitudinal research findings

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