Quality of life and clinical outcome in psoriasis patients using intermittent cyclosporin

Touw, C.R.; Roijen, Leona Hakkaart-van; Verboom, Paul; Paul, Carle; Rutten, Frans; Finlay, A.Y.

doi:10.1046/j.1365-2133.2001.04183.x

Cited by 121 publications

(126 citation statements)

References 23 publications

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“…This confirms the results of Perrott et al [38] and Richards et al [39] who postulated that ratings of severity of psoriasis are poor predictors of HRQoL, and that clinical severity of psoriasis and anatomical area of involvement have no strong impact on psychological distress and disability [40]. …”

Section: Discussionsupporting

confidence: 80%

Disease Severity, Quality of Life and Health Care in Plaque-Type Psoriasis: A Multicenter Cross-Sectional Study in Germany

Augustin¹,

Krüger

Radtke³

et al. 2008

Dermatology

239

230

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Background: Plaque-type psoriasis produces significant morbidity, has negative effects on patients’ health-related quality of life (HRQoL), and represents an economic burden. Objectives: The assessment of disease severity, HRQoL and health care in plaque-type psoriasis in everyday German medical practice. Methods: Details of patients with plaque-type psoriasis were recorded by 48 dermatologists in Germany. During the visit, demographic data, medical history, previous and current treatments, occupational impairment, the current state of the disease (measured by the Psoriasis Area and Severity Index; PASI), overall lesion severity, and HRQoL were evaluated. Results: In total, 1,511 plaque-type psoriasis patients were included. The average PASI score was 12.0. The average Dermatology Life Quality Index score was 8.6. Among the patients with the severest psoriasis (PASI >20), only 45.4% had ever been prescribed systemic treatments. Conclusions: Psoriasis patients have a reduced HRQoL and are not sufficiently treated in practice. A more widespread use of systemic treatment and the definition of treatment goals are essential to improve the standard of care for psoriasis patients.

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Section: Discussionsupporting

confidence: 80%

Disease Severity, Quality of Life and Health Care in Plaque-Type Psoriasis: A Multicenter Cross-Sectional Study in Germany

Augustin¹,

Krüger

Radtke³

et al. 2008

Dermatology

239

230

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“…The mean DLQI total score in patients in this study (9.2) was of the same magnitude as those reported in other skin conditions that are assumed to impose a physical or psychological burden, such as inpatient or outpatient psoriasis (13.9–4.5) [18,19,20,21,22,23,24], Hailey-Hailey disease (6.1) [25], rosacea (7.8) [20], acne (9.3–4.3) [13, 20, 21, 23, 26], pruritus (10.5–10) [13, 20], contact dermatitis (10.8) [21] and atopic dermatitis (12.5–5.8) [13,21,22,23,24, 27]. On the basis of a comparative literature analysis, the HRQOL impairment associated with hyperhidrosis can exceed that of the severest dermatological diseases as measured by the DLQI.…”

Section: Discussionsupporting

confidence: 61%

Primary Focal Hyperhidrosis: Disease Characteristics and Functional Impairment

et al. 2006

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Background: There are few published data on the clinical characteristics of hyperhidrosis. Objective: To describe the functional impairment caused by primary focal hyperhidrosis. Methods: Patients with hyperhidrosis (n = 345) were enrolled at the Department of Dermatology, University of Würzburg. Controls (n = 154) were a convenience sample of subjects without hyperhidrosis. Hyperhidrosis characteristics, health-related quality of life and functional impairment were assessed. Results: Patients with axillary hyperhidrosis reported a later age at onset and a higher prevalence of a family history of hyperhidrosis than patients with palmar hyperhidrosis. Sixty-three percent of patients reported occupational impairment related to hyperhidrosis. Hyperhidrosis patients reported emotional and physical impairment, with a greater proportion of the axillary group reporting impairment. More than 50% of patients reported moderate to extreme impairment in personal relationships and in social situations. Conclusion: Primary focal hyperhidrosis is a serious medical condition, affecting work productivity, daily activities, emotional well-being and personal relationships.

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“…Positive impact on HRQL has recently been reported for infliximab, etanercept, alefacept, efalizumab and cyclosporine [47,48,49,50,51,52]. Work productivity has not been included as an outcome in psoriasis studies yet.…”

Section: Discussionmentioning

confidence: 99%

Work Limitations and Productivity Loss Are Associated with Health-Related Quality of Life but Not with Clinical Severity in Patients with Psoriasis

2006

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Background: According to current guidelines the cost of productivity loss should be considered in pharmacoeconomic analyses. The cost of health-related productivity loss in psoriasis patients is unknown. Objective: To estimate the cost of productivity loss in psoriasis and its association with health-related quality of life and clinical disease severity. Methods: Cross-sectional study, recruitment of adult participants through Internet advertisements. 201 (72.3%) out of 278 eligible participants completed the study. Health-related work productivity loss, quality of life and clinical severity of psoriasis were assessed by standardized instruments. Results: Indirect costs of productivity loss clearly exceed the total direct cost. In contrast to objective clinical disease severity, health-related quality of life (measured by the Dermatology Life Quality Index) is an independent predictor of work productivity. Conclusions: There is good reason to believe that intervention can reduce health-related productivity loss by improving patients’ quality of life. Savings from increased work productivity might offset comparatively high acquisition costs of biological agents.

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Quality of life and clinical outcome in psoriasis patients using intermittent cyclosporin

Cited by 121 publications

References 23 publications

Disease Severity, Quality of Life and Health Care in Plaque-Type Psoriasis: A Multicenter Cross-Sectional Study in Germany

Disease Severity, Quality of Life and Health Care in Plaque-Type Psoriasis: A Multicenter Cross-Sectional Study in Germany

Primary Focal Hyperhidrosis: Disease Characteristics and Functional Impairment

Work Limitations and Productivity Loss Are Associated with Health-Related Quality of Life but Not with Clinical Severity in Patients with Psoriasis

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