Quality of life and costs of patients prior to colorectal surgery

Pattamatta, Madhuri; Smeets, Boudewijn J. J.; Evers, Silvia M. A. A.; Peters, Emmeline G.; Luyer, Misha; Hiligsmann, Mickaël

doi:10.1080/14737167.2019.1628641

Cited by 9 publications

(8 citation statements)

References 23 publications

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“…The societal costs for CRC survivors are lower compared to the average annual health expenses of the general Dutch population in 2017 (€5100), but are higher compared to the average annual health expenses of individuals with cancer in 2017 (€343) or individuals with CRC (€35) [ 48 , 49 ]. Additionally, CRC survivors 2–10 years post-diagnosis showed slightly lower utility scores compared to the general Dutch population (0.87) [ 37 ], lower utility scores than patients prior to CRC surgery in the Netherlands (0.88) [ 50 ], and higher utility scores compared to CRC patients in the primary treatment phase [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

“…The highly variable costs are in accordance with previous studies, where the majority of cancer survivors had little or no costs and a small number incurred very high costs [ 51 ]. The mean costs in this population were hypothesized to be lower than costs in the primary treatment phase, which several studies have demonstrated to be associated with highest costs [ 50 , 52 ]. Interestingly, the mean costs of this study were only slightly lower than the costs of rehabilitation (€2106, 6–18 months from diagnosis) and remission (€2812, > 18 months from diagnosis) phase as demonstrated by Färkkilä et al [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

“…The significantly higher utility score in males (0.85) compared to females (0.77) is consistent with the results of Versteegh et al [ 37 ]. Pattamatta et al state that males oftentimes score their health better in comparison with females [ 50 ]. It is suggested that this gender difference in quality of life is explained by lower income, lower educational level, increased household responsibilities, and increased comorbidities of females compared to males [ 63 – 65 ].…”

Section: Discussionmentioning

confidence: 99%

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The burden of colorectal cancer survivors in the Netherlands: costs, utilities, and associated patient characteristics

et al. 2021

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Purpose The aim of this study is to assess the societal burden of colorectal cancer (CRC) survivorship 2–10 years post-diagnosis in terms of (1) societal costs, and (2) quality of life/utilities, and to analyze associated patient characteristics. Methods This is a cross-sectional, bottom-up prevalence-based burden of disease study, conducted from a societal perspective in the Netherlands. In total, 155 CRC survivors were included. Utilities were measured by the EQ-5D-5L, using the Dutch tariffs. A cost questionnaire was developed to obtain cost information. Subgroup analyses were performed, based on patient characteristics and sensitivity analyses. Results Of all CRC survivors, 81(54%) reported no problems for mobility, 133(88%) for self-care, 98(65%) for daily activities, 59(39%) for pain/discomfort, and 112(74%) for anxiety/depression on the EQ-5D-5L. The average EQ-5D-5L utility score was 0.82 (SD = 0.2) on a scale from 0 (death) to 1 (perfect health). Significant differences in utility score were found for gender, tumor stage, number of comorbidities, and lifestyle score. The average societal costs per CRC survivor per 6 months were estimated at €971 (min = €0, max = €32,425). Significant differences in costs were found for the number of comorbidities. Conclusions This study shows a considerable burden of CRC survivors 2–10 years after diagnosis, in comparison with survivors sooner after diagnosis and with healthy individuals in the Netherlands. Implications for Cancer Survivors Long-term care of CRC survivors should focus on improving the societal burden by identifying modifiable factors, as summarized in the WCRF/AICR lifestyle score, including body composition, physical activity, and diet.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The burden of colorectal cancer survivors in the Netherlands: costs, utilities, and associated patient characteristics

et al. 2021

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“…To our knowledge, in one study, healthcare utilisation per patient was estimated using the iMCQ at 0.88 ± 0.15. [24] Under the assumption of a small or medium effect of our eHealth strategy (d = 0.35), an α of 0.05 and a power of 0.80, a total sample size of 260 patients is required. The total study population is set at 280 patients (140 patients per arm) to account for loss to follow-up and nonadherence to the intervention.…”

Section: Sample Size Calculationmentioning

confidence: 99%

IMPROV-ED trial: eHealth programme for faster recovery and reduced healthcare utilisation after CABG

Steenbergen¹,

Veghel²,

Woorst³

et al. 2020

Neth Heart J

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Background After coronary artery bypass grafting (CABG), healthcare utilisation is high and is partly unplanned. eHealth applications have been proposed to reduce healthcare consumption and to enable patients to get actively involved in their recovery. This way, healthcare expenses can be reduced and the quality of care can be improved. Objectives We aim to evaluate whether the use of an eHealth programme can reduce unplanned healthcare utilisation and improve mental and physical health in the first 6 weeks after discharge in patients who underwent CABG. In addition, patient satisfaction and use of the eHealth programme will be evaluated. Methods For this single-centre randomised controlled trial, at least 280 patients referred for CABG will be included at the preoperative outpatient clinic and randomised to an intervention or control group. The intervention group will have access to an eHealth programme, which consists of online educational videos developed by the Dutch Heart Foundation and postoperative video consultations with a physician. The control group will receive standard care and will not have access to the eHealth programme. The primary endpoint is healthcare utilisation; other endpoints include anxiety, duration of recovery, quality of life and patient satisfaction. Participants will complete several questionnaires at 6 time points during the study. Results Patient enrolment started in February 2020 and completion of the follow-up period is expected in August 2021. Conclusion This randomised trial was initiated to test the hypothesis that patients who are partaking in our eHealth programme use less unplanned care and experience a better quality of life, less anxiety and a faster recovery than controls.

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“…Theoretically, a non-invasive intervention with an estimated low complication rate could potentially result in a favorable QoL as a result of better tolerance. The effects on QoL in patients with metastatic stage IV colorectal cancer has been evaluated in studies of various designs, and in different settings (12)(13)(14). Well established questionnaires give the opportunity to include many patients and reach reliable and validated results in a practical manner.…”

mentioning

confidence: 99%

Quality of Life for Patients With Incurable Stage IV Colorectal Cancer: Randomized Controlled Trial Comparing Resection Versus Endoscopic Stenting

Fiori

Lamazza

Sterpetti

et al. 2019

In Vivo

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Background/Aim: A prospective randomized open label parallel trial, comparing the quality of life (QoL) after endoscopic placement of a self-expandable metal stent or primary tumor resection, in patients with stage IV colorectal cancer was performed. Patients and Methods: Thirty-three patients affected with stage IV colorectal cancer and unresectable metastases were randomly assigned into two groups: Group 1 (16 patients), that underwent selfexpandable metal stent positioning and Group 2 (17 patients), in which primary tumor resection was performed. Karnofsky performance scale and QoL assessment using the EQ-5D-5L™ questionnaire was administered before treatment and thereafter at 1, 3 and 6 months. Results: At 1 month, index values showed a statistically significant deterioration of the QoL in patients of Group 2 when compared to those of Group 1 (p=0.001; 95%CI=0.065-0.211) whereas, at 6 months, index values showed a statistically significant deterioration of the QoL in patients of Group 1 (p<0.025; 95%CI=0.017-0.238). Conclusion: QoL in patients affected with stage IV colorectal cancer has a bimodal fluctuation pattern: at 1month it was better in patients that received stent, but at 6months it was significantly better in patients submitted to surgical resection.

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Quality of life and costs of patients prior to colorectal surgery

Cited by 9 publications

References 23 publications

The burden of colorectal cancer survivors in the Netherlands: costs, utilities, and associated patient characteristics

The burden of colorectal cancer survivors in the Netherlands: costs, utilities, and associated patient characteristics

IMPROV-ED trial: eHealth programme for faster recovery and reduced healthcare utilisation after CABG

Quality of Life for Patients With Incurable Stage IV Colorectal Cancer: Randomized Controlled Trial Comparing Resection Versus Endoscopic Stenting

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