Quality of life and disease severity in patients with atopic dermatitis

Holm, Jesper Grønlund; Agner, Tove; Clausen, Maja‐Lisa; Thomsen, Simon Francis

doi:10.1111/jdv.13689

Cited by 102 publications

(92 citation statements)

References 37 publications

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“…Mozaffari et al found that patients perceived dressing, undressing, and bath time as being most problematic, while the dimension “family activities” was least affected. Holm et al also found that dressing was particularly problematic. Using the EQ‐5D as a measure of QoL, daily activity, and pain/discomfort parameters were reported to be most affected in patients .…”

Section: Resultsmentioning

confidence: 99%

“…Mean overall DLQI scores ranged across studies from 4.9 (small effect on patient's QoL) to 20.5 (very large effect on patient's QoL). In studies which looked at differences across the dimensions of QoL, the areas that were most affected as measured using the DLQI were symptoms and feelings surrounding AD; patients felt embarrassed or self‐conscious because of their AD, and symptoms such as itchy, sore, painful, and stinging skin had a detrimental impact on their QoL . Personal relationships were the least affected dimension of QoL .…”

Section: Resultsmentioning

confidence: 99%

“…Eighteen of these reported significant correlations between disease severity and DLQI; the more severe the disease, the lower the QoL. In seven of these studies, QoL using the DLQI was compared with disease severity measured using the SCORAD . These studies were pooled together using random‐effects meta‐analysis (see Fig.…”

Section: Resultsmentioning

confidence: 99%

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Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

2020

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Atopic dermatitis (AD) can affect quality of life (QoL) of adult patients in whom the condition can be severe and persistent. There are currently no systematic reviews of the impact of AD on adults. This paper provides the first systematic literature review and meta‐analysis of the impact of AD on QoL in adults. A systematic search was conducted using MEDLINE, Scopus, and Web of Science for articles published until October 2018. Inclusion criteria were a clinical diagnosis of AD, adult patients, and QoL as an outcome measure. Interventions were excluded. A total of 32 studies were included. While QoL was assessed using Dermatology Life Quality Index (DLQI) in 25 studies, there was heterogeneity in the tools used to measure disease severity across studies. Meta‐analysis of the seven studies that used the SCORAD to measure disease severity showed severity to be significantly related to poorer QoL. The remaining 18 studies also showed increased disease severity significantly related to poorer QoL. When compared to healthy controls, AD patients demonstrated significantly lower QoL, but findings were mixed in studies that compared QoL in AD to other skin conditions. The findings highlight the significant impact that AD has on QoL in adults and the need for validated and relevant QoL measures to be implemented in clinical assessments for AD. Areas that require further research include an exploration of gender differences in QoL and the use of longitudinal study designs to explore factors that may cause differences in QoL ratings.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

2020

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“…Facial eczema could indicate a more negative influence of AD, as shown in the child cohort by the impact on self-rated health compared to non-CAM users. It may constitute a significant disease burden for the patient, and previous studies have documented that facial skin disease affects quality of life significantly more in a negative direction than other locations [13, 23-25], which could be speculated to drive CAM use. Facial eczema is challenging and not always satisfyingly treated by conventional treatments, therefore patients with facial eczema may be willing to try any possible solution.…”

Section: Discussionmentioning

confidence: 99%

Use of Complementary and Alternative Therapies in Outpatients with Atopic Dermatitis from a Dermatological University Department

et al. 2019

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Background: Treatment of atopic dermatitis (AD) may be challenging, therefore some patients seek complementary and alternative medications (CAM). We determined prevalence and predictors for CAM use in a hospital cohort of AD patients. Material and Methods: Between January 1, 2012, and December 31, 2017, AD patients referred to the dermatological outpatient clinic at Bispebjerg Hospital were included in the study. Information on CAM use, demographics and disease characteristics were obtained by questionnaire, and associations were determined by χ² and t test separately for children (< 16 years) and adults (≥16 years). Results: In total 441 filled in the questionnaire on AD, and 433 patients responded to the questions about CAM use: 198 children and 235 adults. A total of 137 (31.6%) had used one or more CAM. CAM use in children was significantly associated with prior use of ≥2 conventional treatments (p = 0.047) and topical calcineurin inhibitors (p = 0.021), a higher number of affected eczema sites (p < 0.001) including more frequent affection of the face and extremities, a higher SCORAD score (p = 0.045), and low mean overall self-rated health (p = 0.003). CAM use in adults was significantly associated with lower age of onset of AD (p = 0.004), comorbid allergic rhinoconjunctivitis (p = 0.039), frequent use of moisturizing cream (p = 0.024), facial and neck eczema (p = 0.005) and high educational level (p = 0.043). Conclusion: CAM use is frequent in both children and adult AD patients. CAM users are characterized by long disease duration, a significant disease burden and by having a longer education. The high prevalence of CAM may indicate that patients’ expectations regarding treatment of AD are not redeemed in the conventional health care system.

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“…Empiriniai tyrimai ir sisteminės tyrimų apžvalgos atskleidžia emocinę asmens būklę ir jo patiriamus sunkumus esant susijusius ne vien su AD, tačiau ir su kitų dermatologinių ligų (psoriazės, dilgėlinės, seborėjos, aknės) raiška bei jų eiga. Odos ligomis sergančių asmenų grupėje nustatomi aukštesni nerimo, depresijos, socialinės disfunkcijos ir žemesni pasitenkinimo gyvenimu ir gyvenimo kokybės įverčiai, šioje grupėje būdingesnė nemiga [36,[40][41][42][43][44]. Taip pat tyrimai pagrindžia socialinės paramos reikšmingumą bei integruoto tarpdisciplininio požiūrio į dermatologinių ligų gydymą svarbą [41].…”

Section: Atopiniu Dermatitu Sergančio Vaiko Emocinio Funkcionavimo Ypunclassified

Integruotas Požiūris Į Vaikų Atopinio Dermatito Raišką: Psichosomatinis Aspektas Ir Sąsajos Su Emocinių Sunkumų Patyrimu

Kerzaitė

Ėmužytė

Kinčinienė

et al. 2017

Medicinos Teorija Ir Praktika

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Reikšminiai žodžiai: vaikai, atopinis dermatitas, emociniai sunkumai, somatizacija. Darbo tikslas. Pristatyti integruotą požiūrį į vaikų atopinį dermatitą, apimant psichosomatinį ligos aspektą. Atopinis dermatitas – lėtinė odos liga, kuri siejama su įvairiais psichikoje vykstančiais procesais. Apžvelgiant šiuolaikinę literatūrą ir tyrimus, atliktus šia tema, atsiskleidžia atopinio dermatito daugialypiškumas, o tai tampa argumentu tyrinėti ligą psichosocialiniame kontekste. Tai leidžia geriau suprasti sergančiojo emocinę būseną ir psichinius procesus, kurie taip pat atlieka svarbų vaidmenį ligos raidoje. Moksliniai tyrimai minėtomis kryptimis galėtų tapti vertingu indėliu, kad būtų geriau suprantami atopiniu dermatitu sergančio vaiko poreikiai ir būtų organizuojama veiksmingesnė kompleksinė sergančiojo priežiūra, integruojant ir psichologinę pagalbą.

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Quality of life and disease severity in patients with atopic dermatitis

Abstract: AD impacts negatively on the QoL, proportional to the severity of the disease. Furthermore, female sex and facial eczema are associated with low QoL. Positive FLG null mutation status is not associated with QoL or disease severity.

Cited by 102 publications

References 37 publications

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis

Use of Complementary and Alternative Therapies in Outpatients with Atopic Dermatitis from a Dermatological University Department

Integruotas Požiūris Į Vaikų Atopinio Dermatito Raišką: Psichosomatinis Aspektas Ir Sąsajos Su Emocinių Sunkumų Patyrimu

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