Quality of life and functional capacity can be improved in patients with Eisenmenger syndrome with oral sildenafil therapy

Tay, Edgar; Papaphylactou, Maria; Diller, Gerhard Paul; Alonso‐Gonzalez, Rafael; Inuzuka, Ryo; Giannakoulas, George; Harries, Carl; Wort, Stephen J.; Swan, Lorna; Dimopoulos, Konstantinos; Gatzoulis, Michael Α.

doi:10.1016/j.ijcard.2010.02.020

Cited by 72 publications

(35 citation statements)

References 21 publications

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“…Overall Jehn et al 50 Radke et al 24 Alahdab et al 18 Alahdab et al 18 Rostagno et al 13 Rostagno et al 45 Ingle et al 26 Jehn et al 36 Ingle et al 26 Deuschle et al 52 Rostagno et al 46 Bagur et al 48 Zugck et al 21 Pepera et al 32 Goode et al 18 Deuschle et al 52 Faggiano et al 47 Leszek et al 35 Rostagno et al 13 Goode et al 7 Zugck et al 21 Ingle et al 26 Ingle et al 26 Rostagno et al 45 Tay et al 49 Jankowska et al 29 Bagur et al 48 Ates et al 30 Rostagno et al 46 Gary et al 25 Jehn et al 36 Karavidaset al 28 Souza et al 53 Jehn et al 50 Bosnak Güçlü et al 27 Alahdab et al 18 Forman et al 20 Zaidi et al Goscinska-Bis et al 37 Alahdab et al 18 Forman et al 20 Keast et al 31 Vrtovec et al 51 Rostagno et al 45 Souza et al 53 Tay et al 49 Jaski et al 34 Zugck et al …”

Section: Discussionmentioning

confidence: 99%

Correlation of the New York Heart Association Classification and the 6‐Minute Walk Distance: A Systematic Review

Yap

Lim

Gao

et al. 2015

Clinical Cardiology

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Background: Functional status assessment is the cornerstone of heart failure management and trials. The New York Heart Association (NYHA) classification and 6-minute walk distance (6MWD) are commonly used tools; however, the correlation between them is not well understood. Hypothesis: We hypothesised that the relationship between the NYHA classification and 6MWD might vary across studies. Methods: A systematic literature search was performed to identify all studies reporting both NYHA class and 6MWD. Two reviewers independently assessed study eligibility and extracted data. Thirty-seven studies involving 5678 patients were included. Results: There was significant heterogeneity across studies in 6MWD within all NYHA classes: I (n = 16, Q = 934.2; P < 0.001), II (n = 25, Q = 1658.3; P < 0.001), III (n = 30, Q = 1020.1; P < 0.001), and IV (n = 6, Q = 335.5; P < 0.001). There was no significant difference in average 6MWD between NYHA I and II (420 m vs 393 m; P = 0.416). There was a significant difference in average 6MWD between NYHA II and III (393 m vs 321 m; P = 0.014) and III and IV (321 m vs 224 m; P = 0

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Section: Discussionmentioning

confidence: 99%

Correlation of the New York Heart Association Classification and the 6‐Minute Walk Distance: A Systematic Review

Yap

Lim

Gao

et al. 2015

Clinical Cardiology

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“…More recently, two studies have addressed the long-term impact of DTT in ES patients [59,60], confirming a sustained positive impact on WHO class and 6MWD in the long term. Improvement in quality of life has also been demonstrated [61]. Limited data are available on the effect of DTT in CHD patients with patent or previously closed left-to-right shunt lesions: Schulze-Neick and colleagues reported improved functional status as well as exercise capacity in 33 CHD-PAH patients treated with bosentan over a mean period of 2.1 years [62].…”

Section: Eras and Pdesmentioning

confidence: 99%

The challenge of managing pulmonary arterial hypertension in adults with congenital heart disease

Radke

Diller

Baumgartner

2013

Expert Review of Cardiovascular Therapy

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“…Aunque el nivel de evidencia del uso de sildenafil sea menor que el del Bosentan (no hay estudios controlados aleatorizados para sildenafil) éste tiene una especial consideración en su uso, especialmente si no existe disponibilidad de Bosentan en el contexto de la paciente, tal como ocurrió en este caso. (24,(25)(26)(27)(28)(29)(30). El Sildenafil ha demostrado mejoría en: parámetros hemodinámicos, capacidad de ejercicio, índice de disnea de Borg, clase funcional, calidad de vida y buena tolerancia.…”

Section: Discussionunclassified

Hipertensión arterial pulmonar (síndrome de Eisenmenger) en el embarazo. Presentación de caso

Cortés¹,

Vásquez²,

Méndez³

et al. 2015

Rev. Sal. Bosq

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ResumenEl síndrome o complejo Eisenmenger (hipertensión arterial pulmonar asociada a cardiopatía congénita) es una entidad poco frecuente en la población y en la mujer gestante, describiéndose una alta mortalidad materno fetal (20 al 40%) y complicaciones obstétricas relacionadas con la entidad: amenaza de parto pretérmino, restricción del crecimiento fetal, insuficiencia placentaria, entre otras.Este artículo describe el caso de una mujer en segundo trimestre de embarazo con síndrome de Eisenmenger, diagnosticada y manejada en un hospital de cuarto nivel colombiano, con el fin de revisar la literatura al respecto, pero, de especial interés, con el fin de compartir la experiencia en el manejo médico de esta situación tan AbstractEisenmenger complex (pulmonary arterial hypertension associated with congenital heart disease) is a rare entity in the individual population and in pregnant women, describing a high maternal and fetal mortality (20 to 40%) and it's well known obstetric complications related entity: preterm delivery, intrauterine growth restriction, placental insufficiency, etc.We describe the case of a pregnant woman in the second trimester with Eisenmenger´s syndrome who was monitored, diagnosed and managed by high complex hospital, in order to review scientific literature and illustrate the experience of medical management of Eisenmenger´s Syndrome during the pregnancy.

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Quality of life and functional capacity can be improved in patients with Eisenmenger syndrome with oral sildenafil therapy

Cited by 72 publications

References 21 publications

Correlation of the New York Heart Association Classification and the 6‐Minute Walk Distance: A Systematic Review

Correlation of the New York Heart Association Classification and the 6‐Minute Walk Distance: A Systematic Review

The challenge of managing pulmonary arterial hypertension in adults with congenital heart disease

Hipertensión arterial pulmonar (síndrome de Eisenmenger) en el embarazo. Presentación de caso

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