Quality of life and functional capacity are adversely affected in osteoarthritis patients with neuropathic pain

Abstract

The aim of this study was to examine the neuropathic pain component of knee osteoarthritis (OA) patients and to investigate the relationship between neuropathic pain, disease stage, functional state, depression, anxiety, and quality of life. This study included 60 patients with knee OA. All demographic data and radiological results were recorded. Visual Analog Scale (VAS), Timed Up and Go Test, Chair Stand Test, Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC), PainDETECT questionnaire, DN4 questionnaire, Short form-36 questionnaire, and Hospital Anxiety Depression Scale were performed for each patient. Neuropathic pain was detected in 66.7% of patients based on the PainDETECT scale and in 46.7% of patients based on DN4 scale. VAS-resting, OA grade, WOMAC scores, and SF-scores showed a significant difference in patients that detected neuropathic pain with PainDETECT (p<0.05). Based on the DN4 scale, patients with neuropathic pain had significantly higher WOMAC scores and significantly lower SF-36 scores (p<0.05). The PainDETECT questionnaire scores showed positive correlations with Timed Up-and-go Test, VAS-resting, WOMAC scores, Hospital Anxiety Depression Scale scores, and a negative correlation with all SF-36 scores (p<0.05). DN4 questionnaire scores showed a negative correlation with SF-36 scores and positive correlation with WOMAC scores (p<0.05). To conclude, it should be kept in mind that patients with knee OA who describe intense pain may have a neuropathic component involved in the clinical condition. Quality of life and functional capacity are adversely affected in patients with knee OA who have neuropathic pain. This should be taken into account while planning the treatment of these patients.

Assessment of Frequency of Neuropathic Pain in Knee Osteoarthritis and its Relation to Functional State, Quality of Life and Depression

“…pain detect and Douleur Neuropathique en 4 Questions (DN4) scale] to assess neuropathic pain in a small number of patients (60-100 patients) and have investigated the quality of life and functional status of these patients. [6][7][8] In the present study, we aimed to determine the presence of neuropathic pain using the DN-4 scale in patients with knee OA. Besides, we investigated its relation to functional state, quality of life and depression symptoms.…”

Current drug treatment for osteoarthritis

“…с помощью опросников DN4 и Pain DETECT обнаружили нейропатические дескрипторы у 46,7% и 66,7% пациентов с ОС, соответственно. Признаки нейропатии прямо коррелировали с интенсивностью боли по ВАШ и нарушением функциональной активности по WOMAC [25].…”

Using a new tool to evaluate the functional capacity of patients with HTLV-1 associated myelopathy/Tropical spastic paraparesis (HAM/TSP)

“…We are aware that a variety of other factors can negatively affect functional capacities, such as advancing age, depression, level of physical activity and pain 26 . Although 67% of the individuals with HAM/TSP performed structured exercises or physiotherapy, all were classified as weak in comparison to the control group.…”