Quality of life and functional limitations in persons with epilepsy

Karakis, Ioannis; Boualam, Nada; Moura, Lidia; Howard, David H.

doi:10.1016/j.eplepsyres.2023.107084

Cited by 11 publications

(3 citation statements)

References 38 publications

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“…The cause is currently unknown, but may be related to unrecognized seizures in the setting of delayed diagnosis and treatment, or potentially related to the underlying etiology or disrupted brain networks. [4][5][6][7][8] At the time of initial seizure evaluation, brain imaging is a core component of the diagnostic workup and is ideally performed with magnetic resonance imaging (MRI). Brain MRI is particularly useful for identifying focal etiologies that are missed on computed tomographic imaging.…”

Section: Introductionmentioning

confidence: 99%

“…Even among people with epilepsy who do not have overt intellectual disability or history of definite developmental delay, more subtle difficulties with academic‐based learning and work can be seen. The cause is currently unknown, but may be related to unrecognized seizures in the setting of delayed diagnosis and treatment, or potentially related to the underlying etiology or disrupted brain networks 4–8 …”

Section: Introductionmentioning

confidence: 99%

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Later onset focal epilepsy with roots in childhood: Evidence from early learning difficulty and brain volumes in the Human Epilepsy Project

et al. 2023

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ObjectiveVisual assessment of magnetic resonance imaging (MRI) from the Human Epilepsy Project 1 (HEP1) found 18% of participants had atrophic brain changes relative to age without known etiology. Here, we identify the underlying factors related to brain volume differences in people with focal epilepsy enrolled in HEP1.MethodsEnrollment data for participants with complete records and brain MRIs were analyzed, including 391 participants aged 12–60 years. HEP1 excluded developmental or cognitive delay with intelligence quotient <70, and participants reported any formal learning disability diagnoses, repeated grades, and remediation. Prediagnostic seizures were quantified by semiology, frequency, and duration. T1‐weighted brain MRIs were analyzed using Sequence Adaptive Multimodal Segmentation (FreeSurfer v7.2), from which a brain tissue volume to intracranial volume ratio was derived and compared to clinically relevant participant characteristics.ResultsBrain tissue volume changes observable on visual analyses were quantified, and a brain tissue volume to intracranial volume ratio was derived to compare with clinically relevant variables. Learning difficulties were associated with decreased brain tissue volume to intracranial volume, with a ratio reduction of .005 for each learning difficulty reported (95% confidence interval [CI] = −.007 to −.002, p = .0003). Each 10‐year increase in age at MRI was associated with a ratio reduction of .006 (95% CI = −.007 to −.005, p < .0001). For male participants, the ratio was .011 less than for female participants (95% CI = −.014 to −.007, p < .0001). There were no effects from seizures, employment, education, seizure semiology, or temporal lobe electroencephalographic abnormalities.SignificanceThis study shows lower brain tissue volume to intracranial volume in people with newly treated focal epilepsy and learning difficulties, suggesting developmental factors are an important marker of brain pathology related to neuroanatomical changes in focal epilepsy. Like the general population, there were also independent associations between brain volume, age, and sex in the study population.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Later onset focal epilepsy with roots in childhood: Evidence from early learning difficulty and brain volumes in the Human Epilepsy Project

et al. 2023

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“…Epilepsy is a chronic neurological disorder and adult patients with epilepsy may have psychiatric and cognitive comorbidities, with frequent social repercussions and impaired quality of life (QoL). 1 It is known that patients with epilepsy have a worse perception of QoL when compared to the general population and people who suffer from other chronic illnesses. 2 3 In epilepsy, several clinical and psychosocial factors and the perception of social support are related to QoL.…”

Section: Introductionmentioning

confidence: 99%

Family support in adults with epilepsy

Tedrus,

Leandro-Merhi,

Etchegaray

et al. 2023

Arq Neuropsiquiatr

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Background The perception of family support in chronic disease can be relevant. Objective To assess the perception of family support in adult patients with epilepsy (PWEs) and relate it to quality of life (QoL) and clinical aspects. Methods Data from the Perceived Family Support Inventory (IPFS) of 130 PWEs were related to the clinical variables, QOLIE-31 scores, and the Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) with statistical tests, with p < 0.05. Results The mean age was 49.9 ± 17.2 years, and the duration of epilepsy was 20.8 ± 15.4 years. The presence of depression (scores ≥ 15) was associated with lower family support. Being married and non-occurrence of depression were the variables associated with a higher IPFS score (R = 0.2112), in the multiple linear regression. Conclusion The perception of greater family support was associated with demographic aspects, the absence of depression, and better QoL. Family relationships may play an essential role in health adjustment behaviors and QoL in epilepsy.

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