Quality of Life and Gastrointestinal Symptoms in Long-Term Treated Dermatitis Herpetiformis Patients: A Cross-Sectional Study in Finland

Pasternack, Camilla; Kaukinen, Katri; Kurppa, Kalle; Mäki, Markku; Collin, Pekka; Reunala, Timo; Salmi, Teea

doi:10.1007/s40257-015-0149-1

Cited by 17 publications

(22 citation statements)

References 41 publications

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“…In the present study, the coeliac disease controls were further found to have worse self-reported general health, and they had more gastrointestinal symptoms at the time of the study compared to the DH patients. These results fit with our recent study that likewise found a better quality of life and fewer gastrointestinal symptoms among long-term treated DH patients compared to treated coeliac disease patients [ 41 ].…”

Section: Discussionsupporting

confidence: 92%

Prognosis of Dermatitis Herpetiformis Patients with and without Villous Atrophy at Diagnosis

et al. 2018

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Dermatitis herpetiformis (DH) is a cutaneous manifestation of coeliac disease. At diagnosis, the majority of patients have villous atrophy in the small bowel mucosa. The objective of this study was to investigate whether the presence or absence of villous atrophy at diagnosis affects the long-term prognosis of DH. Data were gathered from the patient records of 352 DH and 248 coeliac disease patients, and follow-up data via questionnaires from 181 DH and 128 coeliac disease patients on a gluten-free diet (GFD). Of the DH patients, 72% had villous atrophy when DH was diagnosed, and these patients were significantly younger at diagnosis compared to those with normal small bowel mucosa (37 vs. 54 years, p < 0.001). Clinical recovery on a GFD did not differ significantly between the DH groups, nor did current adherence to a GFD, the presence of long-term illnesses, coeliac disease-related complications or gastrointestinal symptoms, or quality of life. By contrast, the coeliac disease controls had more often osteopenia/osteoporosis, thyroid diseases, malignancies and current gastrointestinal symptoms compared to the DH patients. In conclusion, villous atrophy at the time of DH diagnosis does not have an impact on the clinical recovery or long-term general health of DH patients.

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Section: Discussionsupporting

confidence: 92%

Prognosis of Dermatitis Herpetiformis Patients with and without Villous Atrophy at Diagnosis

et al. 2018

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“…We further detected an improvement in DH patients' life quality after one year of GFD treatment, reaching the level of healthy controls in most values measured, and being superior to that in the classical coeliac disease patients from the same series (6). We have previously shown in a different series that DH patients' quality of life is comparable to that of the healthy population even in the long term (18), which supports our present results. In this study female patients with DH were found to have a poorer quality of life than male patients with DH.…”

Section: Discussionsupporting

confidence: 90%

“…Female patients had a longer diagnostic delay in the current study compared with male patients, again as has been shown in coeliac disease (22). Furthermore, female DH and coeliac disease patients have been shown to have more severe GI symptoms than males (18,23). The above-mentioned factors are also both linked to diminished quality of life in coeliac disease (5,19,24), and thus might offer other explanations for the gender differences in quality of life.…”

Section: Discussionsupporting

confidence: 65%

Gastrointestinal Symptoms Increase the Burden of Illness in Dermatitis Herpetiformis: A Prospective Study

Pasternack

Kaukinen²,

Kurppa³

et al. 2017

Acta Derm Venerol

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“…However, according to current knowledge, the QoL of patients with DH seems to be reduced, but importantly, already after adherence to a GFD for 1 year, the QoL increases to the level of controls (35). The positive impact of GFD on DH patients' QoL is also supported by another study, in which the Qol of long-term GFD-treated DH patients was equal to that of controls, and slightly better than that of long-term treated coeliac patients (74).…”

Section: Long-term Prognosis On a Gluten-free Dietmentioning

confidence: 75%

Current Concepts of Dermatitis Herpetiformis

Salmi

Hervonen²

2020

Acta Derm Venerol

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Dermatitis herpetiformis (DH) is an autoimmune skin disease that causes itchy, blistering rash, typically on the elbows, knees and buttocks. DH and coeliac disease share the same genetic background, glutendependent enteropathy and antibody response against tissue transglutaminase. DH is currently considered a cutaneous manifestation of coeliac disease, and the prevailing hypothesis is that DH develops as a late manifestation of subclinical coeliac disease. The incidence of DH is decreasing contemporarily with the increasing incidence of coeliac disease. The IgA immune response in DH skin is directed against epidermal transglutaminase, while the autoantigen in the gut is tissue transglutaminase. Granular IgA deposition in the papillary dermis is pathognomonic for DH, and is a finding used to confirm the diagnosis. The treatment of choice for DH is a life-long gluten-free diet, which resolves the rash and enteropathy, increases quality of life, and offers a good long-term prognosis.

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Quality of Life and Gastrointestinal Symptoms in Long-Term Treated Dermatitis Herpetiformis Patients: A Cross-Sectional Study in Finland

Abstract: We conclude that long-term GFD-treated DH patients do not suffer from the burden of dietary treatment and have a quality of life comparable to that of controls.

Cited by 17 publications

References 41 publications

Prognosis of Dermatitis Herpetiformis Patients with and without Villous Atrophy at Diagnosis

Prognosis of Dermatitis Herpetiformis Patients with and without Villous Atrophy at Diagnosis

Gastrointestinal Symptoms Increase the Burden of Illness in Dermatitis Herpetiformis: A Prospective Study

Current Concepts of Dermatitis Herpetiformis

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