Quality of Life and Hearing Eight Years After Sudden Sensorineural Hearing Loss

Härkönen, Kati; Kivekäs, Ilkka; Rautiainen, Markus; Kotti, Voitto; Vasama, Juha-Pekka

doi:10.1002/lary.26133

Cited by 44 publications

(41 citation statements)

References 24 publications

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“…Historically, the consequences of monaural auditory deprivation have not been given much attention, as they were believed to be minimal. However, more recent studies have revealed that the effect of unilateral hearing loss (UHL) and single-sided deafness (SSD)on processing of auditory stimuli may have far reaching consequences affecting quality of life (QoL) (Harkonen et al, 2017) as well as educational outcomes and listening effort (Lewis et al, 2016). It may also affect language development in children (Anne et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

An fMRI-study on single-sided deafness: Spectral-temporal properties and side of stimulation modulates hemispheric dominance

Heggdal

Aarstad

Brännström

et al. 2019

NeuroImage: Clinical

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Objective Our main aim was to investigate the blood oxygenation level dependent (BOLD) response to monaural and binaural speech- and non-speech stimuli as measured with fMRI in subjects with single-sided deafness and in normal hearing controls. We hypothesised that the response to monaural stimulation in both normal hearing subjects and persons with single-sided deafness would vary with the complexity and nature of the stimuli and the side of stimulation. Design Patients with left- and right single-sided deafness and controls with normal hearing receiving either binaural or monaural stimuli were tested using speech and non-speech auditory stimuli in an event-related fMRI experiment . Study sample Twenty-two patients with single-sided deafness after treatment for vestibular schwannoma and 50 normal hearing controls. Results Normal hearing persons receiving right side monaural stimuli activate bilateral temporal regions. Activation following left side monaural stimulation is more right lateralized. Persons with single-sided deafness respond similarly to controls to monaural stimulation. Persons with right side single-sided deafness show activation of frontal cortical regions not seen in persons with left side single-sided deafness following speech stimuli. This is possibly related to increased effort and more frequently reported problems with communication. Right side single-sided deafness is related to increased activation of areas usually related to processing of degraded input, including the thalamus. Conclusion Hemispheric dominance following monaural auditory stimulation is modulated by the spectral-temporal properties of the stimuli and by which ear is stimulated. Differences between patients with right- and left side deafness suggests that right side deafness is related to increased activation of areas involved in processing of degraded input.

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Section: Introductionmentioning

confidence: 99%

An fMRI-study on single-sided deafness: Spectral-temporal properties and side of stimulation modulates hemispheric dominance

Heggdal

Aarstad

Brännström

et al. 2019

NeuroImage: Clinical

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“…The mainstay of treatment options for idiopathic SSNHL include oral steroids, intratympanic steroid injections or a combination of both. 5 The National Institute for Health and Care Excellence, in their recent guidelines on hearing loss (NG98), highlighted the paucity of evidence assessing the comparative effectiveness of these treatments and issued a high priority research recommendation to identify the most effective route of administration of steroids as a first-line treatment for idiopathic SSNHL. 10 The National Institute for Health Research (NIHR) Health Technology Assessment Programme has since released a commissioned call for a trial to address this question.…”

Section: Withmentioning

confidence: 99%

“…In 71%-90% of cases, the cause is unknown despite investigation, and these cases are termed idiopathic SSNHL. 3 4 Idiopathic SSNHL is a serious condition, adversely impacting people's lives 5…”

Section: Introductionmentioning

confidence: 99%

“…Idiopathic SSNHL is a serious condition, adversely impacting people’s lives 5 with research showing associations with emotional distress, depression, difficulties at work and impaired social integration. 6 7 Its prognosis is poorly understood and may depend on age, comorbidities, degree of hearing loss, audiometric configuration, presence of vertigo, treatment received, time between onset of hearing loss and treatment, and other factors.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study

Mandavia

Hannink²,

Ahmed

et al. 2020

BMJ Open

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IntroductionThe mainstay of treatment for idiopathic sudden sensorineural hearing loss (SSNHL) includes oral steroids, intratympanic steroid injections or a combination of both. The National Institute for Health and Care Excellence, in their recent hearing loss guidelines, highlighted the paucity of evidence assessing the comparative effectiveness of these treatments; and the National Institute for Health Research (NIHR) Health Technology Assessment Programme has since released a commissioned call for a trial to identify the most effective route of administration of steroids as a first-line treatment for idiopathic SSNHL. For such trials to be run effectively, reliable information is needed on patients with SSNHL: where they present, numbers, demographics, treatment pathways, as well as outcomes. This study will collect these data in a nationwide cohort study of patients presenting with SSNHL across 97 National Health Service (NHS) trusts. The study will be delivered through ear, nose and throat (ENT) trainee networks, the NIHR Clinical Research Network (CRN) Audiology Champions and the NIHR CRN. Importantly, this study will also provide a dataset to develop a prognostic model to predict recovery for patients with idiopathic SSNHL. The study objectives are to: (1) map the patient pathway and identify the characteristics of adult patients presenting to NHS ENT and hearing services with SSNHL, (2) develop a prognostic model to predict recovery for patients with idiopathic SSNHL and (3) establish the impact of idiopathic SSNHL on patients’ quality of life (QoL).Methods and analysisStudy design: national multicentre prospective cohort study across 97 NHS trusts.Inclusion criteria: adult patients presenting to NHS ENT and hearing services with SSNHL.Outcomes: change in auditory function; change in QoL score.Analysis: multivariable prognostic model, using prespecified candidate predictors. Mean change in QoL scores will be calculated from initial presentation to follow-up.Ethics and disseminationHealth Research Authority and NHS Research Ethics Committee approved the study. Publication will be on behalf of study sites and collaborators.Trial registration numberClinicalTrials.gov Registry (NCT04108598).

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“…Socially, the lack of understanding and perception of speech lead to social isolation and a decline in communication. With the sudden lifestyle change, many patients suffer from depression, and even those who recover experience debilitating anxiety that the hearing loss will reoccur [ 7 , 9 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Lassa fever–induced sensorineural hearing loss: A neglected public health and social burden

et al. 2018

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Although an association between Lassa fever (LF) and sudden-onset sensorineural hearing loss (SNHL) was confirmed clinically in 1990, the prevalence of LF-induced SNHL in endemic countries is still underestimated. LF, a viral hemorrhagic fever disease caused by Lassa virus (LASV), is endemic in West Africa, causing an estimated 500,000 cases and 5,000 deaths per year. Sudden-onset SNHL, one complication of LF, occurs in approximately one-third of survivors and constitutes a neglected public health and social burden. In the endemic countries, where access to hearing aids is limited, SNHL results in a decline of the quality of life for those affected. In addition, hearing loss costs Nigeria approximately 43 million dollars per year. The epidemiology of LF-induced SNHL has not been characterized well. The complication of LF induced by SNHL is also an important consideration for vaccine development and treatments. However, research into the mechanism has been hindered by the lack of autopsy samples and relevant small animal models. Recently, the first animal model that mimics the symptoms of SNHL associated with LF was developed. Preliminary data from the new animal model as well as the clinical case studies support the mechanism of immune-mediated injury that causes SNHL in LF patients. This article summarizes clinical findings of hearing loss in LF patients highlighting the association between LASV infection and SNHL as well as the potential mechanism(s) for LF-induced SNHL. Further research is necessary to identify the mechanism and the epidemiology of LF-induced SNHL.

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Quality of Life and Hearing Eight Years After Sudden Sensorineural Hearing Loss

Abstract: 4 Laryngoscope, 127:927-931, 2017.

Cited by 44 publications

References 24 publications

An fMRI-study on single-sided deafness: Spectral-temporal properties and side of stimulation modulates hemispheric dominance

An fMRI-study on single-sided deafness: Spectral-temporal properties and side of stimulation modulates hemispheric dominance

Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study

Lassa fever–induced sensorineural hearing loss: A neglected public health and social burden

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