Quality of life and its association with insight, adverse effects of medication and use of atypical antipsychotics in patients with bipolar disorder and schizophrenia in remission

Yen, Cheng Fang; Cheng, Chun‐Yu; Huang, Chi Fen; Yen, Ju-Yu; Ko, Chih Hung; Chen, Cheng Sheng

doi:10.1111/j.1399-5618.2007.00577.x

Cited by 75 publications

(56 citation statements)

References 45 publications

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“…Patients assess their satisfaction for each item over the past 2 weeks on a 5-point scale (from 1 = ''very dissatisfied'' to 5 = ''very satisfied'') [33,34]. The WHOQOL-BREF has been a widely used SQOL instrument in schizophrenia research [35,36], and use of the WHOQOL-BREF allows our findings to be compared with those of previous studies.…”

Section: Measures and Proceduresmentioning

confidence: 99%

Subjective quality of life and suicidal behavior among Taiwanese schizophrenia patients

Kao

Liu

Cheng

et al. 2011

Soc Psychiatry Psychiatr Epidemiol

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Schizophrenia is associated with a high suicidal risk, of which depressive and psychotic symptoms are the major correlates. Again, the present study confirms and extends previous research showing that dissatisfied SQOL, particularly dissatisfaction with social relationships, should be considered in the assessment of suicidal risk in outpatients with schizophrenia, even when accounting other possible confounding factor such as depression.

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Section: Measures and Proceduresmentioning

confidence: 99%

Subjective quality of life and suicidal behavior among Taiwanese schizophrenia patients

Kao

Liu

Cheng

et al. 2011

Soc Psychiatry Psychiatr Epidemiol

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“…The mean EQ-VAS score at 3 years for remitters was similar to that reported for the general population (König et al, 2009). Previous reports have found that quality of life in patients with schizophrenia in symptomatic remission is lower than in healthy individuals (Yen et al, 2008). However, the study by Yen et al (2008) did not use a representative sample of general population subjects and did not specify for how long the patients included had been in remission.…”

mentioning

confidence: 98%

“…For this, the regression model can be adjusted for other factors known to impact on quality of life and to be associated with remission (e.g. age, gender and medication) (Haro et al, 2006;Yen et al, 2008;Potkin et al, 2009). Finally, we have described the relationship between functional remission and quality of life.…”

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confidence: 99%

Symptomatic remission and patient quality of life in an observational study of schizophrenia: Is there a relationship?

Haro

Novick

Perrin³

et al. 2014

Psychiatry Research

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This analysis aimed to examine the association between remission and quality of life (QOL) in schizophrenia. In post-hoc analyses of the 3-year, prospective, observational Schizophrenia Outpatients Health Outcomes (SOHO) study, we compared the QOL of patients who achieved symptomatic and clinical remission with those who did not, and the factors associated. Symptomatic remission was defined as achieving a score of ≤ 3 on the Clinical Global ImpressionsSchizophrenia (CGI-SCH) scale, maintained for at least 6 months and without hospitalization. QOL was patient self-rated using the European-QOL. Of the 6516 patients analysed, 38% were in symptomatic remission 12 months post-baseline and 52% at 36 months. Functional remission remained fairly constant from 12 months to 36 months (22.4% at both time points). At all visits from 12 to 36 months, patient QOL and social functioning were significantly higher for patients in symptomatic remission. QOL was higher in patients in functional remission compared to those not in functional remission at all time points. Patients with maintained symptomatic remission over the 3-year follow-up had a much greater improvement in QOL than patients with no symptomatic remission or symptomatic remission for part of the period. Factors associated with a better QOL included symptomatic remission, paid employment, socially active, having a higher CGI-SCH cognitive score, good compliance, and a better baseline QOL. Achieving symptomatic remission in schizophrenia is associated with an increase in patient self-perceived QOL, even when adjusting for confounding factors.

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“…The subjective quality of life (SQoL) is one of the most important outcomes among the impaired health-related outcomes for people with schizophrenia, with growing interest for healthcare providers (Lin et al, 2012). Many studies (Carpenter & Buchanan, 1994;Hegarty et al, 1994;Hooley, 2010;Yen et al, 2008) have shown that an individual's SQoL, including physical and psychological aspects, is impaired in people with a mental illness such as schizophrenia. Mental health professionals could improve the health and wellbeing of people with schizophrenia by finding ways to improve their SQoL.…”

mentioning

confidence: 99%

The Mediation Role of Self-Esteem for Self-Stigma on Quality of Life for People With Schizophrenia: A Retrospectively Longitudinal Study

Huang

Chen

Pakpour

et al. 2018

Journal of Pacific Rim Psychology

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B ackground: Among patients with schizophrenia, there is evidence of a negative association between self-stigma and subjective quality of life (SQoL), and self-esteem was an important mediator in the association. We attempted to use a longitudinal study to investigate the aforementioned mediation on a sample with schizophrenia. Methods: We used longitudinal data retrieved from medical records of a psychiatric centre between June 2014 and December 2015. In the data, we retrieved information of self-stigma using the Self-Stigma Scale -Short; SQoL, using the WHO questionnaire on the Quality of Life -Short Form; and self-esteem, using the Rosenberg Self-Esteem Scale. All the measures were evaluated five times. Linear mixed-effect models accompanied by Sobel tests were used to tackle the mediating effects. Results: Data from 74 patients (57 males) with schizophrenia were eligible for analysis; their mean (SD) age was 39.53 (10.67); mean age of onset was 22.95 (8.38). Self-esteem was a mediator for patients in physical (p = .039), psychological (p = .003), and social SQoL (p = .004), but not in environment SQoL (p = .051). Conclusion: Based on our findings, mental health professionals could tailor different programs to patients with schizophrenia, such as self-stigma reduction and self-esteem improvement programs. However, treatment as a whole should be sensitive to both self-stigma and selfesteem. Also, we should consider individuals' health and wellbeing from social perspectives of disability rather than the medical model of disability emphasising symptoms and medications.

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Quality of life and its association with insight, adverse effects of medication and use of atypical antipsychotics in patients with bipolar disorder and schizophrenia in remission

Abstract: The results of the present study indicate that subjects with BD are dissatisfied with their QOL, even when they are in a remitted state. Clinicians must consider the negative influences of insight and adverse effects of medication on QOL of patients with BD and schizophrenia in remission.

Cited by 75 publications

References 45 publications

Subjective quality of life and suicidal behavior among Taiwanese schizophrenia patients

Subjective quality of life and suicidal behavior among Taiwanese schizophrenia patients

Symptomatic remission and patient quality of life in an observational study of schizophrenia: Is there a relationship?

The Mediation Role of Self-Esteem for Self-Stigma on Quality of Life for People With Schizophrenia: A Retrospectively Longitudinal Study

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