Quality of Life and Its Contributing Factors in Patients with  Familial Hypercholesterolaemia in Malaysia

Razali, Salmi; Ismail, Zaliha; Chua, Y.A.; Nawawi, H.

doi:10.21834/e-bpj.v4i10.1621

Cited by 2 publications

(2 citation statements)

References 27 publications

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“…General practitioners or even Lipid Specialists should be sufficiently trained to deliver effective consultation and management to FH patients. FH patients should be advised to undergo therapeutic lifestyle changes, including adjusting their dietand involve in physical activities.Educated FH patients who are aware of the CHD risk tend to practise healthy lifestyle, such as cease smoking (Razali et al, 2019). The establishment of Familial Hypercholesterolaemia Support Group, a community-level voluntary organisation, may provide education to the FH patients and their family members on how to live with FH, and morally support the FH patients to practise healthy lifestyle.…”

Section: Discussionmentioning

confidence: 99%

Classification of Familial Hypercholesterolaemia Using Ordinal Logistic Regression

Jamaludin¹,

Wah²,

Nawawi³

et al. 2020

JST

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Familial hypercholesterolaemia (FH) is a genetic disease that causes the elevation of low-density lipoprotein cholesterol (LDL-C), which subsequently leads to premature coronary heart disease (CHD). Features which have been reported to be associated with FH include lipids level, tendon xanthomata, and history of CHD. The Ordinal Logistic Regression model using the classification of FH patients with the Dutch Lipid Clinic Network Criteria (DLCN) as the dependent variable (where 1=Possible, 2=Probable, 3=Definite) was developed and evaluated for different types of link functions. The FH patients (n = 449) were recruited from health screening programmes conducted in hospitals and clinics in Malaysia from 2010 to 2018. Results indicate there is a significant association between FH categories with demographic factors (ethnicity and smoking) and physical symptoms (corneal arcus and xanthomata). The Ordinal Logistic Regression using Cauchit link function has lower Akaike Information Criterion (AIC) value, higher Nagelkerke's R-Square and classification accuracy compared to Probit and Logit link function, diastolic blood pressure, corneal arcus and xanthomata were found to be significant covariates of FH.

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Section: Discussionmentioning

confidence: 99%

Classification of Familial Hypercholesterolaemia Using Ordinal Logistic Regression

Jamaludin¹,

Wah²,

Nawawi³

et al. 2020

JST

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“…Patients with FH will suffer reduced life expectancy by up to 30 years compared those without FH (Alonso, Mata, & Mata, 2005). Without early treatment, CVDs and other complications caused patients with FH to have a poor quality of life (Razali, Ismail, Yung et al, 2019). Hence, preventive measures of CVDs including taking lipid-lowering agents, stress management and lifestyle interventions (such as taking healthy diet, performing vigorous physical activities, exercise and smoking cessation) are vital.…”

Section: Literature Reviewmentioning

confidence: 99%

Physical Activity and Healthy Diet in Patients with Familial Hypercholesterolaemia

Razali

Wah

Chua

et al. 2020

jABs

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Performing vigorous physical activity and taking balanced diet are parts of healthy lifestyles of patients with Familial Hypercholesterolaemia (FH). This study aimed to describe the status of engagement with physical activity and a healthy diet, and their contributing factors. FH patients diagnosed using Dutch Lipid Clinic Network criteria were given validated questionnaires to assess sociodemography, illness characteristics, the status of engagement with physical activity and healthy diet, psychological elements, family support and level of barrier. Significant contributing factors were receiving treatment, level of barrier and intention for behavioural change. The findings may inform the strategy for lifestyle modification of patients with FH. Keywords: Familial Hypercholesterolaemia; lifestyle; physical activity; healthy diet. eISSN: 2514-7528 © 2020 The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment- Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/jabs.v5i17.374

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Quality of Life and Its Contributing Factors in Patients with Familial Hypercholesterolaemia in Malaysia

Cited by 2 publications

References 27 publications

Classification of Familial Hypercholesterolaemia Using Ordinal Logistic Regression

Classification of Familial Hypercholesterolaemia Using Ordinal Logistic Regression

Physical Activity and Healthy Diet in Patients with Familial Hypercholesterolaemia

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