Quality of life and mortality among survivors of acute respiratory distress syndrome in South Korea: a nationwide cohort study

Choi, Heungho; Song, In-Ae; Oh, Tak Kyu

doi:10.1007/s00540-022-03036-9

Cited by 6 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, a previous study reported that the median value of total hospitalization cost was USD 2,555.6 (IQR: 1,335.2-5,757.4) among patients with sepsis in South Korea in 2005-2012 (18). Moreover, we reported recently that the mean expense of hospitalization among survivors of ARDS was USD 9,714.1 (standard deviation: 12,266.7) in South Korea (19). Therefore, the differences in ECMO support cost should be interpreted and compared carefully with previous studies (8)(9)(10), considering the unique feature of the South Korean NHIS system.…”

Section: Discussionmentioning

confidence: 82%

The economic burden and long-term mortality in survivors of extracorporeal membrane oxygenation in South Korea

Oh¹,

Song²

2022

Ann Transl Med

View full text Add to dashboard Cite

Background: The economic burden for extracorporeal membrane oxygenation (ECMO) survivors is a critical issue. We investigated the total healthcare costs for one year following ECMO support and its association with three-year all-cause mortality.Methods: This population-based cohort study used data from the National Health Insurance Service (NHIS) in South Korea. Adult ECMO survivors (age ≥18 years who were alive ≥365 days following ECMO support) from January 1, 2005, to December 31, 2018, were included. The total healthcare costs for one year included all the expenses for hospital and outpatient clinic visits after discharge.Results: In total, 6,044 patients were included in the final analysis comprising 3,566 (59.0%) in the cardiac indication group, 658 (10.9%) in the respiratory indication group, and 1,820 (30.1%) in the "other" group.The median total healthcare cost was United States Dollars (USD) 46,308.0 [interquartile range (IQR): 25,727.0-86,924.8]. The median ECMO support and hospital stay durations were three (IQR: 1-7) days and 25 (IQR: 15-31) days. In the multivariable Cox regression model, a USD 1000 increase in the total healthcare cost was associated with an increase in the three-year all-cause mortality (hazard ratio, 1.01; 95%

show abstract

Section: Discussionmentioning

confidence: 82%

The economic burden and long-term mortality in survivors of extracorporeal membrane oxygenation in South Korea

Oh¹,

Song²

2022

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…The types of disability included physical, brain lesions, visual, hearing, speech, intellectual, mental, renal, heart, respiratory, hepatopathy, intestinal and urinary stulae, and epilepsy. Each disability was rigorously classi ed according to legal standards by specialist physicians in each respective eld, with a grading system ranging from 1 to 6 33 . Grades 1 through 3 were considered severe disabilities, while grades 4 through 6 were categorized as mild to moderate disabilities, respectively.…”

Section: Data Collection and De Nitionsmentioning

confidence: 99%

One-Year Mortality and Associated Factors in Older Hospitalized COVID-19 Survivors: A Nationwide Cohort Study in Korea

Kim,

Moon

et al. 2024

Preprint

View full text Add to dashboard Cite

Background This study aimed to evaluate the 1-year mortality rate among older patients with COVID-19 discharged from hospital and to identify the risk factors associated with this outcome. Methods Using a COVID-19 dataset from the Korean National Health Insurance System, this study’s evaluation period spanned from October 8, 2020, to December 31, 2021. The primary outcome was the 1-year mortality rate following hospital discharge. A logistic regression model was employed for multivariable analysis to estimate the odds ratios for the outcomes, and the Kaplan-Meier method was used to analyze differences in 1-year survival rates. Results Of the 66,810 COVID-19 patients aged 60 years or older who were hospitalized during the study period, the in-hospital mortality rate was 4.8% (n = 3219). Among the survivors (n = 63,369), the 1-year mortality rate was 4.9% (n = 3093). Non-survivors, compared to survivors, were significantly older (79.2 ± 9.5 vs. 68.9 ± 7.8, P < .001) and exhibited a lower rate of COVID-19 vaccination (63.1% vs. 91.8%, P < .001). Additionally, non-survivors experienced a higher incidence of organ dysfunction, and a greater proportion required mechanical ventilation (14.6% vs. 1.0%, P < .001) and extracorporeal membrane oxygenation (4.0% vs. 0.1%, P < .001). Multivariable logistic regression analysis identified older age, male sex, immunosuppression, organ dysfunction, severity of illness, and corticosteroid use during hospitalization as factors associated with death within 1 year after hospital discharge. However, vaccination was found to have a long-term protective effect against mortality among COVID-19 survivors. Conclusions and Implications The 1-year mortality rate after hospital discharge for older COVID-19 patients was comparable to the in-hospital mortality rate for these patients in Korea. The long-term mortality rate among hospitalized older COVID-19 patients was influenced by demographic factors and the severity of illness experienced during hospitalization.

show abstract

“…Due to the diverse causes and complex pathogenesis, ARDS treatment is also unspecific, poorly described, and considered an important unmet medical need [ 7 , 8 ]. In addition to the high rates of morbidity and mortality, ARDS has a great impact on the quality of life of patients requiring a better understanding of their pathogenesis and new treatment options [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Absence of CCR2 Promotes Proliferation of Alveolar Macrophages That Control Lung Inflammation in Acute Respiratory Distress Syndrome in Mice

Oliveira

Pollenus

Berghmans

et al. 2022

IJMS

View full text Add to dashboard Cite

Acute respiratory distress syndrome (ARDS) consists of uncontrolled inflammation that causes hypoxemia and reduced lung compliance. Since it is a complex process, not all details have been elucidated yet. In a well-controlled experimental murine model of lipopolysaccharide (LPS)-induced ARDS, the activity and viability of macrophages and neutrophils dictate the beginning and end phases of lung inflammation. C-C chemokine receptor type 2 (CCR2) is a critical chemokine receptor that mediates monocyte/macrophage activation and recruitment to the tissues. Here, we used CCR2-deficient mice to explore mechanisms that control lung inflammation in LPS-induced ARDS. CCR2−/− mice presented higher total numbers of pulmonary leukocytes at the peak of inflammation as compared to CCR2+/+ mice, mainly by enhanced influx of neutrophils, whereas we observed two to six-fold lower monocyte or interstitial macrophage numbers in the CCR2−/−. Nevertheless, the time needed to control the inflammation was comparable between CCR2+/+ and CCR2−/−. Interestingly, CCR2−/− mice presented higher numbers and increased proliferative rates of alveolar macrophages from day 3, with a more pronounced M2 profile, associated with transforming growth factor (TGF)-β and C-C chemokine ligand (CCL)22 production, decreased inducible nitric oxide synthase (Nos2), interleukin (IL)-1β and IL-12b mRNA expression and increased mannose receptor type 1 (Mrc1) mRNA and CD206 protein expression. Depletion of alveolar macrophages significantly delayed recovery from the inflammatory insult. Thus, our work shows that the lower number of infiltrating monocytes in CCR2−/− is partially compensated by increased proliferation of resident alveolar macrophages during the inflammation control of experimental ARDS.

show abstract

Quality of life and mortality among survivors of acute respiratory distress syndrome in South Korea: a nationwide cohort study

Cited by 6 publications

References 27 publications

The economic burden and long-term mortality in survivors of extracorporeal membrane oxygenation in South Korea

The economic burden and long-term mortality in survivors of extracorporeal membrane oxygenation in South Korea

One-Year Mortality and Associated Factors in Older Hospitalized COVID-19 Survivors: A Nationwide Cohort Study in Korea

Absence of CCR2 Promotes Proliferation of Alveolar Macrophages That Control Lung Inflammation in Acute Respiratory Distress Syndrome in Mice

Contact Info

Product

Resources

About