Quality of life and neuropsychological changes in mild head trauma

Lima, Daniela Paoli de Almeida; Filho, Charles Simão; Abib, Simone de Campos Vieira; Figueiredo, Luiz Francisco Poli de

doi:10.1016/j.injury.2007.11.008

Cited by 43 publications

(9 citation statements)

References 23 publications

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“…A recent cross-sectional study of QoL in patients with NCC from Mexico reported deficits in both mental and physical domains compared with controls [24]. Other neurological conditions that have demonstrated impairments in quality of life in Latin America include head trauma [25] and spinal cord injury [26].…”

Section: Discussionmentioning

confidence: 99%

Cognitive Changes and Quality of Life in Neurocysticercosis: A Longitudinal Study

et al. 2012

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BackgroundFew studies have focused on the cognitive morbidity of neurocysticercosis (NCC), one of the most common parasitic infections of the central nervous system. We longitudinally assessed the cognitive status and quality of life (QoL) of patients with incident symptomatic NCC cases and matched controls.Methodology/Principal FindingsThe setting of the study was the Sabogal Hospital and Cysticercosis Unit, Department of Transmissible Diseases, National Institute of Neurological Sciences, Lima, Peru. The design was a longitudinal study of new onset NCC cases and controls. Participants included a total of 14 patients with recently diagnosed NCC along with 14 healthy neighborhood controls and 7 recently diagnosed epilepsy controls. A standardized neuropsychological battery was performed at baseline and at 6 months on NCC cases and controls. A brain MRI was performed in patients with NCC at baseline and 6 months. Neuropsychological results were compared between NCC cases and controls at both time points. At baseline, patients with NCC had lower scores on attention tasks (p<0.04) compared with epilepsy controls but no significant differences compared to healthy controls. Six months after receiving anti-parasitic treatment, the NCC group significantly improved on tasks involving psychomotor speed (p<0.02). QoL at baseline suggested impaired mental function and social function in both the NCC and epilepsy group compared with healthy controls. QoL gains in social function (p = 0.006) were noted at 6 months in patients with NCC.Conclusions/SignificanceNewly diagnosed patients with NCC in this sample had mild cognitive deficits and more marked decreases in quality of life at baseline compared with controls. Improvements were found in both cognitive status and quality of life in patients with NCC after treatment.

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Section: Discussionmentioning

confidence: 99%

Cognitive Changes and Quality of Life in Neurocysticercosis: A Longitudinal Study

et al. 2012

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“…Cognitive deficits induced by brain injury can persist over time, especially following moderate or severe injuries 3. The aim of the present study was to compare VF performance at 6 and 12 months after the trauma in a same group of patients with DAI.…”

Section: Introductionmentioning

confidence: 97%

“…Head injuries typically induce transient cognitive deficits;3 however, these aberrations may persist following moderate or severe injuries. Cognitive processes that may be affected by TBI include mental flexibility, attention, set-shifting, planning, organization, sequencing, judgment, verbal fluency (VF), working memory, and impulsivity 4…”

Section: Introductionmentioning

confidence: 99%

Improvement of verbal fluency in patients with diffuse brain injury over time

Zaninotto¹,

Guirado²,

Baldivia³

et al. 2014

NDT

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BackgroundDiffuse axonal injury (DAI), a common cause of neurological sequelae in patients with traumatic brain injury (TBI), is considered one of the most prevalent forms of primary neuronal injury in patients with severe TBI. Cognitive deficits induced by DAI can persist over time, especially following moderate or severe injuries. The aim of the present study was to compare verbal fluency (VF) performance at 6 and 12 months after the trauma in a same group of patients with DAI.MethodsEighteen patients with moderate to severe DAI and 17 healthy volunteers were enrolled. All DAI participants had sustained a TBI at least 6 months prior to the start of the study, were between 18 and 50 years of age, and had at least 4 years of education. The VF test was administered within an extensive neuropsychological test battery. We evaluated the same patients at 6 months (DAI1 group) and 12 months (DAI2 group) and compared the results of neuropsychological tests with a control group of healthy volunteers who were matched to patients for sex, age, and educational level.ResultsIn comparison to controls, the DAI1 group produced significantly fewer words. The DAI2 group produced significantly more semantic words than DAI1 (P<0.05) and demonstrated a trend towards the production of more clusters for letter A (P=0.09) and total words generated in a phonemic test (P=0.09). No significant differences were observed between DAI2 and the control group in the total number of words generated in phonetic FAS or semantic fluency scores.ConclusionThe present findings may be useful in the construction of a management plan for long-term TBI rehabilitation that considers the trauma of each patient. Further, our results suggest the VF test is a suitable instrument for the assessment of cognitive difficulties following TBI.

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“…Mild traumatic brain injury has been referred to as a “silent epidemic” because the problems experienced by patients after injury are often unnoticed but can have profound consequences, such as long-term physical, mental, social, or occupational sequelae (3–5). For the majority of patients, MTBI follows a natural course in which the symptoms rapidly resolve within 3 months.…”

Section: Introductionmentioning

confidence: 99%

Transcranial Direct Current Stimulation for Post-Concussion Syndrome: Study Protocol for a Randomized Crossover Trial

et al. 2017

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BackgroundMild traumatic brain injury (MTBI) represents 70–80% of all treated brain injuries. A considerable proportion of MTBI patients experience post-concussion symptoms for a prolonged period after MTBI, and these symptoms are diagnosed as persistent post-concussion syndrome (PPCS). PPCS is defined as a range of physical, cognitive, and emotional symptoms. However, memory and executive dysfunction seems to be one of the most debilitating symptoms. Recently, non-invasive brain stimulation has been studied as a potential treatment method for traumatic brain injury (TBI) patients. Therefore, our primary goal is to verify the effects of transcranial direct current stimulation (tDCS) in patients with PPCS who demonstrate cognitive deficits in long-term episodic memory, working memory, and executive function following MTBI.Methods/designThis is a randomized crossover trial of patients with a history of MTBI with cognitive deficits in memory and executive function. Thirty adult patients will be randomized in a crossover manner to receive three weekly sessions of anodal tDCS (2 mA) at left dorsolateral prefrontal cortex, left temporal cortex, and sham stimulation that will be performed at 7-day intervals (washout period). The clinical diagnosis of PPCS will be determined using the Rivermead Post-Concussion Symptoms Questionnaire. Patients who meet the inclusion criteria will be assessed with a neuropsychological evaluation. A new battery of computerized neuropsychological tests will be performed before and immediately after each stimulation. Statistical analysis will be performed to determine trends of cognitive improvement.DiscussionThere is paucity of studies regarding the use of tDCS in TBI patients, and although recent results showed controversial data regarding the effects of tDCS in such patients, we will address specifically patients with PPCS and MTBI and no brain abnormalities on CT scan other than subarachnoid hemorrhage. Moreover, due to the missing information on literature regarding the best brain region to be studied, we will evaluate two different regions to find immediate effects of tDCS on memory and executive dysfunction.Clinical Trial Registration, identifier NCT02292589 ().

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Quality of life and neuropsychological changes in mild head trauma

Cited by 43 publications

References 23 publications

Cognitive Changes and Quality of Life in Neurocysticercosis: A Longitudinal Study

Cognitive Changes and Quality of Life in Neurocysticercosis: A Longitudinal Study

Improvement of verbal fluency in patients with diffuse brain injury over time

Transcranial Direct Current Stimulation for Post-Concussion Syndrome: Study Protocol for a Randomized Crossover Trial

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