Quality of Life and Patient-Reported Outcomes in Endometrial Cancer Clinical Trials

Joly, Florence; McAlpine, Jessica N.; Nout, Remi A.; Åvall‐Lundqvist, Elisabeth; Shash, Emad; Friedlander, Michael

doi:10.1097/igc.0000000000000299

Cited by 27 publications

(29 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Characteristics associated with HRQoL have mostly been evaluated in cross-sectional studies [6][7][8][9] which included small and selective samples [6] or did not cover a broad range of HRQoL outcomes [10]. Other studies evaluated HRQoL as part of a clinical trial, with selective samples [8,11]. As evaluated in clinical trials, a poorer HRQoL has been found in patients with a higher tumor stage [12] and in patients receiving radiotherapy or chemotherapy compared to patients without adjuvant therapy [8,11].…”

Section: Introductionmentioning

confidence: 99%

Changes in health-related quality of life among gynecologic cancer survivors during the two years after initial treatment: a longitudinal analysis

et al. 2019

View full text Add to dashboard Cite

Background: While many cancer survivors experience persistent impairments in health-related quality of life (HRQoL) for extended periods of time, others recover soon after treatment. The aim of this research is to assess changes in health-related quality of life in endometrial and ovarian cancer survivors during two years post initial treatment, and to assess clinical and sociodemographic characteristics associated with those changes. Methods: This prospective population-based cohort study includes longitudinal data of endometrial (N ¼ 221) and ovarian (N ¼ 174) cancer survivors diagnosed between 2011 and 2014. The EORTC QLQ-C30 functioning scales were used to assess HRQoL after initial treatment and after 6, 12 and 24 months. Clinical (stage, treatment and comorbidities) and sociodemographic (age, marital status and socioeconomic status) characteristics were obtained from the Netherlands Cancer Registry and through self-administered questionnaires. Linear mixed models were used to assess changes in HRQoL over time and characteristics associated with these changes. Results: Among both endometrial and ovarian cancer patients, HRQoL improved within the first 6 months after initial treatment. Changes in HRQoL were mainly associated with clinical characteristics including comorbidities, treatment and tumor stage, and to a lesser extent with sociodemographic characteristics such as socioeconomic status. However, these associations varied per tumor type. Endometrial cancer survivors, who received radiotherapy and had no comorbidities, reported greater improvements in some HRQoL scales over time. Ovarian cancer patients who received chemotherapy and with advanced tumor stages reported poorer functioning during treatment. Most functioning domains (global health, physical and role functioning) recovered to levels of patients without chemotherapy or with early-stage disease after 12 months, but cognitive and social functioning remained impaired. Conclusion: Some subgroups of patients, including those with multiple comorbidities, with an advanced tumor stage and who received chemotherapy, may be in need of additional support as they are less likely to show improvements in HRQoL over time.

show abstract

Section: Introductionmentioning

confidence: 99%

Changes in health-related quality of life among gynecologic cancer survivors during the two years after initial treatment: a longitudinal analysis

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Despite the high mortality of cancer, patients diagnosed with cancer survive much longer than ever before due to early detection [1–3], effective treatment [4, 5] and improved health management [6]. However, compared with the general population, most cancer survivors experience poorer quality of life (QOL) in both physical and psychological aspects after cancer diagnosis and its treatment [7, 8]. Meanwhile, longer survival time makes QOL an even more important outcome measure for the population with metastatic disease, for whom a cure is probably not the goal.…”

Section: Introductionmentioning

confidence: 99%

Quality of Life and Its Association with Physical Activity among Different Types of Cancer Survivors

et al. 2016

View full text Add to dashboard Cite

PurposeThe main goal of this study was to compare the quality of life (QOL) and its association with physical activity (PA) among patients diagnosed with different types of cancer. Based on the results, we tentatively present suggestions for the cancer health care model.MethodA cross-sectional study was conducted with 2915 cancer survivors recruited from multi-community cancer rehabilitation centers, all of which were affiliated with the Shanghai Cancer Rehabilitation Club. We collected data including socio-demographic characteristics and information about PA. All the subjects included were asked to complete the European Organization for Research and Treatment Quality of Life Questionnaires (EORTC QLQ-C30) and Functional Assessment of Cancer Therapy—General Questionnaire (FACT-G). Multiple linear regression models were employed to control the potential confounding factors.ResultsLung cancer survivors reported the worst dyspnea. Colorectal cancer survivors claimed the highest level of constipation and diarrhea. Liver cancer survivors indicated greatest loss of appetite and financial difficulties. Generally, survivors with PA tended to reported better QOL, although these associations among liver cancer survivors were not statistically significant. Moreover, survivors of all cancer types who performed PA did not report significant lower level of constipation or diarrhea. The relationship between PA frequency and QOL among cancer survivors remained unexplored.ConclusionsBoth QOL and its association with PA vary among survivors of different cancer types. The detailed results can assist clinicians and public health practitioners with improving health care management.

show abstract

“…Quality of life (QOL) is an increasingly important issue in oncology. Careful consideration of QOL and patient-reported outcomes (PROs) and the integration of these end points in clinical trials is critical to the understanding of how various treatments impact QOL, catalysing the development of effective interventions to reduce late effects (Joly et al, 2014). This is especially important in patients with EC, who generally have promising oncologic outcomes, and long overall survivals.…”

Section: Introductionmentioning

confidence: 99%

Independent psychometric validation of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24)

et al. 2017

View full text Add to dashboard Cite

The endometrial cancer (EC)-specific Quality of Life module of the European Organization for Research and Treatment of Cancer (EORTC QLQ-EN24), was developed and validated in one study. We independently validated and assessed the psychometric properties of the instrument. Two hundred and eight women with EC before surgery, during adjuvant treatment and follow-up; in three different cancer centres completed the EORTC QLQ-C30 and the EN24. The questionnaire's completion rate was 100%, except sexuality items, that were answered by 35% of patients.All item-scale correlations for the multi-item scales exceeded the .4 criterion and correlated well with their own scale, while correlations with the other scales were low.The internal consistency of all multi-item scales were satisfactory (Cronbach's alpha coefficients ranging from .77 to .97). Discriminance for single-item scales was low. The QLQ-EN24 module discriminated well between clinically different patients, and there were no differences in quality of life questionnaire scales between patients with body mass index ≤30 when compared to those with >30. This validation study supports the reliability, as well as convergent and divergent validity of the EORTC QLQ-EN24. The module is a useful instrument for the assessment of QOL in patients with EC. However, data concerning sexuality should be interpreted with caution. K E Y W O R D Sendometrial cancer, quality of life, questionnaire, validation

show abstract

Quality of Life and Patient-Reported Outcomes in Endometrial Cancer Clinical Trials

Cited by 27 publications

References 28 publications

Changes in health-related quality of life among gynecologic cancer survivors during the two years after initial treatment: a longitudinal analysis

Changes in health-related quality of life among gynecologic cancer survivors during the two years after initial treatment: a longitudinal analysis

Quality of Life and Its Association with Physical Activity among Different Types of Cancer Survivors

Independent psychometric validation of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Endometrial Cancer Module (EORTC QLQ-EN24)

Contact Info

Product

Resources

About