Quality of life and related risk factors after breast reconstruction in breast cancer patients

Wang, Xiaoqing; Zhu, Kepeng; Ren, Lei; Li, Hanbing; Lin, Shuai; Xiao, Qing; Wang, Jinlan

doi:10.21037/gs-20-532

Cited by 10 publications

(11 citation statements)

References 13 publications

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“…The results show that the variable age has a significant effect on the symptomatology of survivors in both the EORTC QLQ-C30 and the EORTC QLQ-BR23, where younger women have the highest scores on the scales, except for the items diarrhoea, BRBS andBRHL, with SF, BRSEF, BRSEE, BRFU, BRBS and BRHL being significant items and agreeing with other studies where it was observed that younger women receive more treatment, thus increasing the side effects [ 23 , 48 ]. On the other hand, the symptomatology is higher in the elderly women in BRBRS, BRAS and BRHL, agreeing with two studies where they believe that the main culture/religión and a worse libido generates more symptomatoloy in these items [ 34 , 49 ]. Young women show a significant correlation with the BRFU item ( p = 0.035), where they see worse future prospects than older women, because they are usually the breadwinners or the ones responsible for the children, reporting greater concern for their future health [ 45 , 48 , 50 ].…”

Section: Discussionsupporting

confidence: 77%

Quality of Life in Breast Cancer Survivors in Relation to Age, Type of Surgery and Length of Time since First Treatment

Álvarez-Pardo

Romero-Pérez

Camberos-Castañeda

et al. 2022

IJERPH

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(1) Background: Quality of life assessment is a critical aspect of breast cancer patient outcomes, as diagnosis, prognosis and treatment can have a major impact on quality of life. The aim of this study was to describe the characteristics of the sample and to verify the relationship between quality of life (QOL) in women diagnosed with breast cancer (BC) and their age, type or surgery and time since treatment; (2) Methods: a cross-sectional, descriptive study was conducted with 183 women diagnosed with BC, aged 30–80 years in Mexico. Women’s QOL was assessed using two questionnaires, The European Organization for Research and Treatment of Cancer-Quality of Life Core Questionnaire (EORTC QLQ-C30) and The Breast Cancer Module (EORTC QLQ-BR23). (3) Results: the results show significant differences in several items when the variable age is taken into account, indicating that younger women have poorer social and sexual function, as well as poorer sexual enjoyment and lower expectations of the future. The type of surgery also indicates a significantly better QOL in those women who receive conservative treatment versus a mastectomy; the time elapsed since surgery does not show any significant results, except for sexual functioning and breast-related symptoms where >5 years implies better scores on the items. (4) Conclusions: in conclusion, it is important to take into account the characteristics of women with BC, particularly at the time of treatment, in order to mitigate the impact of the disease on their QOL with the help of a multidisciplinary team.

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Section: Discussionsupporting

confidence: 77%

Quality of Life in Breast Cancer Survivors in Relation to Age, Type of Surgery and Length of Time since First Treatment

Álvarez-Pardo

Romero-Pérez

Camberos-Castañeda

et al. 2022

IJERPH

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“…Studies reported that significant benefits in the quality of life and psychosocial well-being were gained via IBR after mastectomy. Breast reconstruction is increasingly provided as the essential part of postmastectomy rehabilitation ( 13 – 15 ). The oncologic safety of mastectomy followed by IBR is sufficiently confirmed in patients with early-stage breast cancer ( 7 , 16 – 18 ).…”

Section: Discussionmentioning

confidence: 99%

A Single-Center Retrospective Analysis of Local and Distant Relapse of Breast Cancer Following Immediate Breast Reconstruction According to Molecular Subtypes

et al. 2022

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PurposeConcerns have been raised about the oncologic safety of immediate breast reconstruction (IBR) following mastectomy for breast cancer. This study aimed to evaluate locoregional recurrence (LRR) and distant metastasis (DM) of breast cancer according to its molecular subtype in patients who underwent mastectomy alone or IBR after mastectomy.MethodsIn this retrospective cohort study, consecutive breast cancer patients treated by the single senior surgeon (XZ) between February 2010 and December 2014 were eligible. In total, 389 consecutive patients were included; 295 patients underwent mastectomy alone and 94 patients underwent mastectomy with IBR. Data were retrospectively collected and analyzed for LRR and DM stratified by molecular subtypes.ResultsWith a median follow-up of 73 and 87.5 months, 1.69% of patients in the mastectomy alone group developed LRR compared to 0% in the reconstruction group (p = 0.342) and the total incidence of DMs was 11.52% in patients who received mastectomy alone and 7.44% in patients who received postmastectomy IBR (p = 0.262), respectively. The cumulative incidence of LRR was 2.1% vs. 0% for luminal A, 0% vs. 0% for luminal B, 0% vs. 0% for human epidermal growth factor receptor 2 (HER2)-enriched, and 4.5% vs. 0% for triple-negative in the mastectomy alone group compared to the postmastectomy IBR group. The cumulative incidence of DM was 15.5% vs. 5.7% for luminal A, 10% vs. 8.7% for luminal B, 17.3% vs. 0% for HER2-enriched, and 6.8% vs. 7.1% for triple-negative in the mastectomy alone group compared to the postmastectomy IBR group. On multivariable Cox regression analysis, lymph node metastasis was associated with an increased risk of DM in the mastectomy alone group (p = 0.03) and neoadjuvant chemotherapy was associated with an increased risk of DM in the postmastectomy IBR group (p = 0.021).ConclusionThis study suggests that IBR does not have a negative impact on the LRR and DM of breast cancer according to molecular subtypes.

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“…It is generally acknowledged that most IPBR-related complications are associated with age, personal medical history (smoking and overweight/obesity) and adjuvant therapy as risk factors. Once these factors had been matched for the subjects of the current study, no significant differences were seen between the two types of surgery [ 13 , 14 ]. Evaluation of postoperative complications revealed that OIPBR patients had a significantly lower incidence of lymphedema on the surgical side ( p = 0.041) and of readmission ( p = 0.040) compared with THIPBR patients.…”

Section: Discussionmentioning

confidence: 99%

“…The current study revealed no significant differences between OIPBR and THIPBR groups in any score either prior to surgery or at 3-month follow-up. Factors that influence satisfaction and quality of life after breast reconstruction include age, tumor stage, postoperative complications [ 14 ] and nicotine addiction [ 27 ], but some studies have also shown that postoperative implant complications are not associated with lower quality of life scores [ 28 ]. Nicotine addiction was strongly associated with breast satisfaction.…”

Section: Discussionmentioning

confidence: 99%

Immediate Prosthesis Breast Reconstruction: A Comparison Between Ambulatory Surgery Versus Traditional Hospitalization Based on the Propensity Score Matching Method

Chen

Liu

et al. 2022

Aesth Plast Surg

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Background The positive benefits of immediate prosthesis breast reconstruction (IPBR) are incontrovertible. During the COVID-19 pandemic, health care resources became scarce. The implementation of outpatient immediate prosthesis breast reconstruction (OIPBR) can improve the efficiency of medical care and reduce viral exposure. Very few studies have focused on OIPBR and this study aimed to fill this gap by evaluating outcomes of OIPBR compared with traditional hospitalization IPBR (THIPBR) in terms of complications and quality of life. Material and Methods The study enrolled patients undergoing IPBR at Tianjin Medical University Cancer Institute and Hospital between January 1, 2020, and September 30, 2021. Outcomes were defined as postoperative complications and quality of life before reconstruction and at 3-month follow-up. Quality of life was assessed by BREAST-Q questionnaire. Inverse probability of treatment weighting and propensity score matching (PSM) were applied to adjust for confounders. Results A total of 135 patients were enrolled, including 110 with THIPBR and 25 with OIPBR. After matching, baseline characteristics were well balanced. Patients with OIPBR had lower rates of lymphedema on the surgery side (p = 0.041) and readmission (p = 0.040) than patients with THIPBR. No statistically significant differences in the quality of life metrics of psychosocial well-being, sexual well-being, satisfaction with breast and physical well-being of the chest were found between the two groups. Conclusion OIPBR is a safe and efficient alternative to THIBPR during the COVID-19 pandemic. It is recommended when medical conditions allow to conserve medical resources. Accelerated technical training for the performance of OIPBR at the hospital level should be expedited. Level of Evidence III This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Quality of life and related risk factors after breast reconstruction in breast cancer patients

Cited by 10 publications

References 13 publications

Quality of Life in Breast Cancer Survivors in Relation to Age, Type of Surgery and Length of Time since First Treatment

Quality of Life in Breast Cancer Survivors in Relation to Age, Type of Surgery and Length of Time since First Treatment

A Single-Center Retrospective Analysis of Local and Distant Relapse of Breast Cancer Following Immediate Breast Reconstruction According to Molecular Subtypes

Immediate Prosthesis Breast Reconstruction: A Comparison Between Ambulatory Surgery Versus Traditional Hospitalization Based on the Propensity Score Matching Method

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