Introduction Pregnant women require social support and healthcare treatments that are specifically designed to address their quality of life (QoL) during this time, as this will help them get through this crucial stage with more resilience and comfort. Objective This study aimed to assess the relationship between the QoL of pregnant women and social support. Methods A cross-sectional study was conducted involving 423 pregnant women. Data were gathered through the SF-36 scale and the “Multidimensional Scale of Perceived Social Support” in the period of June 1 to September 1, 2023. Results The physical health level was moderate ( M = 46.22 ± 16.1), and the mental health level was also moderate ( M = 46.12 ± 21.8). Social support was rated high ( M = 5.3 ± 1.0), with the highest score in the significant other subscale ( M = 5.9 ± 1.2) and the lowest in the friend's subscale ( M = 4.4 ± 1.6). Furthermore, the analysis revealed a significant positive association between the QoL scores and social support ( p < .05). Conclusions The study confirmed that Palestinian pregnant women had a moderate level of QoL and a high level of perceived social support. Additionally, it established a significant small positive relationship between the QoL scores and social support among pregnant women.