Physical activity (PA) improves dyspnoea, psychological wellbeing and quality of life (QoL) for people with COPD and reduces their risk of exacerbation. However, engagement in PA is low especially amongst those with anxiety and depression, and provision of PA programmes limited in countries with limited resources such as Brazil. We explored the perceptions of 21 people with COPD about the impact of their disease on taking part in community-based PA programmes in Sao Paulo, Brazil through semi-structured telephone interviews from October 2020 to April 2021. Discussions were audio-recorded, transcribed, and analysed using the Framework method. Five main themes were identified: Knowledge about COPD and its management; Self-perception of life with COPD; Knowledge and experiences about depression and anxiety; Opinions on PA and repercussions of COVID-19. COPD was viewed as a neglected disease that led to a reduction in QoL and is dependent on specialist care. PA was considered to be important in bringing physical and mental health benefits but there were barriers in accessibility of formal PR programmes and therefore local community PA programs were considered to be important. People with mental health conditions tended to view PA more negatively. COVID-19 had reduced PA opportunities, access to COPD treatment and social interaction, and was associated with more exacerbations and emotional suffering. In general, this study showed an urgent need to improve knowledge about COPD and its risk factors and management among both patients, the public and primary healthcare professionals. We provide important content for the formulation of public policies for the implementation of specific activity programs for people with COPD in community spaces using local resources and intersectoral partnerships.