Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer

Oskam, I.M.; Leeuw, Irma M. Verdonck‐de; Aaronson, Neil K.; Kuik, Dirk J.; Bree, Remco de; Doornaert, P.; Langendijk, Johannes A.; Leemans, C. René

doi:10.1016/j.radonc.2010.02.005

Cited by 57 publications

(43 citation statements)

References 41 publications

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“…Other side effects include malnutrition and problems with deglutition, mastication, speech, and taste [6]. These functional challenges have a profound impact on quality of life (QOL) [7], which is an important treatment endpoint given that both disease-specific and overall survival have been shown to be affected by deterioration of QOL in this population [8]. …”

Section: Introductionmentioning

confidence: 99%

Survivorship Challenges and Information Needs after Radiotherapy for Oral Cancer

et al. 2016

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PURPOSE Oral cancer (OC) treatment can lead to considerable functional impairment, psychological distress, and decrements in quality of life. Given that limited information and support services are available for cancer survivors, many are turning to the Internet. However, little is known about the specific information and service needs of OC survivors. We conducted a descriptive study to: (1) characterize the associations between OC survivor functional problems and distress; and, (2) describe the Internet use of OC survivors, their satisfaction with existing sources of information/support, and their unmet information and service needs. METHODS Ninety-three oral cancer survivors completed cross-sectional surveys within one-year of completing radiotherapy. RESULTS Clinical levels of distress were 10% for depression and 16% for anxiety. Dental health, smell, and range of motion problems were significant (p<.05) determinants of both depression and anxiety symptoms. Eighty-three percent of survivors used the Internet; most used it to obtain health-related information or support. Unmet information needs included how to live a healthy lifestyle after treatment (87%), strategies for dealing with eating and speaking problems (81%), and information about what to expect in terms of side effects after treatment (76%). CONCLUSION Findings suggest that interventions that teach survivors coping and problem-solving skills to manage and cope with functional impairments may help to alleviate distress. Results of this study support the need for psychoeducational interventions for this population and showcase the potential of the Internet as a feasible mode for future dissemination.

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Section: Introductionmentioning

confidence: 99%

Survivorship Challenges and Information Needs after Radiotherapy for Oral Cancer

et al. 2016

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“…The use of PORT in oral cavity cancer involves substantial acute toxicity, and even more concerning, a significant risk for late effects [8,9] that might impair the patients' quality of life [10,11] yet is not based upon randomized evidence [4]. Some studies have failed to demonstrate a benefit for PORT in head and neck squamous cell carcinoma (HNSCC) [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…N stage 2-3), positive surgical margins and extra-capsular extension (ECE) [4]. The latter two factors, which place individuals at a very high-risk of loco-regional and distant failure, are indications for post-operative chemo-radiation based upon the results of phase III trials and a subsequent meta-analysis [5][6][7].The use of PORT in oral cavity cancer involves substantial acute toxicity, and even more concerning, a significant risk for late effects [8,9] that might impair the patients' quality of life [10,11] yet is not based upon randomized evidence [4]. Some studies have failed to demonstrate a benefit for PORT in head and neck squamous cell carcinoma (HNSCC) [12,13].…”

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confidence: 99%

Lymph node ratio predicts the benefit of post-operative radiotherapy in oral cavity cancer

Urban¹,

Gluck²,

Pfeffer³

et al. 2013

Radiotherapy and Oncology

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“…In particular, emerging data suggest that baseline (pretreatment) quality of life (QOL) assessment or simple objective physical function tests may predict outcomes such as mortality and toxicity in oncology (11)(12)(13) , although there are very limited data in AML patients (10,(14)(15) . A recent study by Klepin et al found that overall survival was significantly shorter for older AML patients with impairment in self-reported cognitive function (a QOL domain) and objectively measured physical function after adjusting for age, performance status and cytogenetic risk group (16) .…”

Section: Introductionmentioning

confidence: 99%

Do quality of life, physical function, or the Wheatley index at diagnosis predict 1-year mortality with intensive chemotherapy in older acute myeloid leukemia patients?

et al. 2016

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Quality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer

Cited by 57 publications

References 41 publications

Survivorship Challenges and Information Needs after Radiotherapy for Oral Cancer

Survivorship Challenges and Information Needs after Radiotherapy for Oral Cancer

Lymph node ratio predicts the benefit of post-operative radiotherapy in oral cavity cancer

Do quality of life, physical function, or the Wheatley index at diagnosis predict 1-year mortality with intensive chemotherapy in older acute myeloid leukemia patients?

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