Quality-of-life assessment in patients who had been surgically treated for cerebellar pilocytic astrocytoma in childhood

Pompili, Alfredo; Caperle, Marco; Pace, Andrea; Ramazzotti, Valerio; Raus, Laura; Jandolo, B.; Occhipinti, Emanuele

doi:10.3171/jns.2002.96.2.0229

Cited by 36 publications

(27 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical importance of this small difference is therefore questionable. However, our findings are in line with findings from other studies that described impaired HRQoL in similar domains, using other HRQoL measures [9,10,[19][20][21]. The reduced HRQoL on the Motor and Cognitive functioning scales can be explained by the high proportion of neurologic impairments seen in these children.…”

Section: Discussionsupporting

confidence: 82%

“…Monitoring of health-related quality of life (HRQoL) is done, for example, in childhood survivors who are treated for a pilocytic astrocytoma [9][10][11], low-grade glioma [12], high-grade glioma [13], craniopharyngioma [14,15], medulloblastoma [16,17], and in heterogeneous groups [18][19][20][21][22][23][24]. In most of these studies, survivors reported a variety of degree of reduction in HRQoL compared with healthy age mates [9,10,[13][14][15][16][18][19][20][21][22][23][24]. This could be explained by the heterogeneity of brain tumors and their treatments.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Health-related quality of life and emotional problems in children surviving brain tumor treatment: A descriptive study of 2 cohorts

Dessens

Herwerden

Aarsen

et al. 2016

Pediatric Hematology and Oncology

View full text Add to dashboard Cite

KEYWORDSBrain diseases; brain neoplasms; child behavior disorders; cohort study; quality of life ABSTRACTThe survival of childhood brain tumors has improved in the past 30 years, but acquired brain injury due to damage caused by tumor invasion and side effects of different treatment modalities frequently occurs. This study focused on residual impairments, health-related quality of life (HRQoL), and emotional and behavioral problems in 2 cohorts of survivors diagnosed and treated for various types of brain tumors. In the 2014 cohort, children reported less negative emotions than healthy children. No increase in emotional or behavioral problems were reported by children in both cohorts, whereas parents reported problems in social functioning and isolation related to a delay in emotional development. Children surviving brain tumor treatment have a reduced quality of life. The authors therefore recommend regular screening of HRQoL and emotional and behavioral problems and referral to specific aftercare.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Health-related quality of life and emotional problems in children surviving brain tumor treatment: A descriptive study of 2 cohorts

Dessens

Herwerden

Aarsen

et al. 2016

Pediatric Hematology and Oncology

View full text Add to dashboard Cite

show abstract

“…This result is in line with prior research showing an altogether favorable long-term prognosis of cognitive functioning in CPA patients. 12,15,21,22 Similarly, long-term CPA survivors included in this study were all well integrated into school or professional life. Of those who had finished their education, all were either employed or self-employed.…”

Section: Discussionmentioning

confidence: 99%

“…This result corresponds with a study by Zuzak and colleagues, 22 who found that CPA patients rated their QoL similarly or even higher than healthy controls. Additionally, another study 21 showed that survivors of surgically removed low-grade CPA tend to have a better QoL than other brain tumor patients. As QoL is generally thought to be related to academic achievement and professional status, it may not be surprising to find such good ratings in a patient group that is quite well integrated in educational and professional life.…”

Section: Discussionmentioning

confidence: 99%

“…Zuzak and colleagues 22 for instance found that CPA patients rated their health-related quality of life (HRQoL) similarly or even higher than a group of healthy controls. Correspondingly, Pompili and colleagues 21 concluded in their study that most CPA patients show no late neurological deficits and report a QoL that is better than in other tumor patient groups.…”

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Cerebellar pilocytic astrocytoma in childhood: Investigating the long-term impact of surgery on cognitive performance and functional outcome

Pletschko

Felnhofer

Lamplmair

et al. 2017

Developmental Neurorehabilitation

View full text Add to dashboard Cite

Objective: Previous studies differ regarding the long-term effects of surgically removed pediatric cerebellar pilocytic astrocytomas (CPA). Thus, the aim of this study was to investigate the long-term impact on neurocognitive and functional outcome and to analyze age as an influencing factor. Methods: Fourteen CPA patients were compared to the age norm and to a group of 14 high-achieving peers regarding cognitive functioning, health-related quality of life (HRQoL), and stress regulation. Mean follow-up time after diagnosis was 13.29 years (range: 3–21 years). Results: Patients showed satisfactory academic achievement and did not differ from the norm except for the bodily dimension of HRQoL. However, there were marked differences in specific neurocognitive functions between patients and high achievers. Age at diagnosis did not influence neurocognitive outcome. Conclusion: CPA patients treated with surgery only seem to have a favorable long-term outcome, yet, in comparison with high achievers specific cognitive impairments become apparent.

show abstract

Functional outcome after low‐grade astrocytoma treatment in childhood

Aarsen

Paquier

Reddingius

et al. 2005

Cancer

153

126

View full text Add to dashboard Cite

The hydrogels assembled from a pair of self‐repulsive but mutually attractive decapeptides are visualized by magnetic resonance imaging (MRI). It is found that in the absence of Gd(III)‐chelate, gelation has little effect on MRI signal intensity. In the presence of Gd(III)‐chelate, gelation leads to significant changes in water relaxation and MR signal intensity. The sol to gel transition is best visualized by T2‐weighted imaging using large echo time with the sol producing a bright spot and the gel producing a dark spot. MRI studies point to high local Gd(III)‐chelate concentration. Small‐angle X‐ray scattering study indicates that this local enrichment of Gd(III)‐chelate has two contributing processes: first, the aggregation of peptides into fibers; second, within peptide fibers, Gd(III)‐chelate further aggregate into clusters. This work demonstrates that the status of peptide‐based hydrogels can be visualized by MRI with the aid of covalently linked Gd(III)‐chelates. This result has implications for monitoring peptide scaffolds in vivo. © 2011 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 96: 734–743, 2011.

show abstract

Quality-of-life assessment in patients who had been surgically treated for cerebellar pilocytic astrocytoma in childhood

Cited by 36 publications

References 31 publications

Health-related quality of life and emotional problems in children surviving brain tumor treatment: A descriptive study of 2 cohorts

Health-related quality of life and emotional problems in children surviving brain tumor treatment: A descriptive study of 2 cohorts

Cerebellar pilocytic astrocytoma in childhood: Investigating the long-term impact of surgery on cognitive performance and functional outcome

Functional outcome after low‐grade astrocytoma treatment in childhood

Contact Info

Product

Resources

About