Quality of Life Assessment in Korean Patients with Pemphigus

Sung, Jae Yong; Roh, Mi Ryung; Kim, Soo Chan

doi:10.5021/ad.2015.27.5.492

Cited by 20 publications

(47 citation statements)

References 20 publications

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“…Nonetheless, this difference did not reach statistical significance. This corroborates findings from three earlier studies examining HRQoL in patients with PV and PF using the SF‐36, DLQI and Skindex‐29 questionnaires . We also observed that patients with PV with mucocutaneous symptoms had the lowest EQ‐5D‐5L index scores, which highlights the importance of additional supportive treatments for patients with mucosal symptoms (e.g.…”

Section: Discussionsupporting

confidence: 90%

“…We acknowledge that there are several limitations of transferring value sets and EQ‐5D scores across different jurisdictions . Thirdly, in previous studies, the presence of antibodies against desmoglein 1 and 3 antigens was associated with disease activity and HRQoL in pemphigus . Our study was a cross‐sectional questionnaire survey; no serum samples were collected from patients that could have allowed us to measure antidesmoglein antibody levels.…”

Section: Discussionmentioning

confidence: 92%

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Validity of the EQ ‐5D in patients with pemphigus vulgaris and pemphigus foliaceus

et al. 2018

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 92%

Validity of the EQ ‐5D in patients with pemphigus vulgaris and pemphigus foliaceus

et al. 2018

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“…Our results are in accordance with earlier studies assessing HRQoL and its predictors in patients with pemphigus by using EQ‐5D, SF‐36, WHOQOL‐BREF, DLQI and Skindex‐29 . Moreover, having a caregiver was associated with lower utilities for current health.…”

Section: Discussionsupporting

confidence: 91%

“…Our results are in accordance with earlier studies assessing HRQoL and its predictors in patients with pemphigus by using EQ-5D, SF-36, WHOQOL-BREF, DLQI and Skindex-29. 14,[40][41][42][43][44][45][46][47] Moreover, having a caregiver was associated with lower utilities for current health. Pemphigus may not only adversely affect HRQoL of patients but also places a burden on caregivers.…”

Section: Discussionmentioning

confidence: 99%

Patient‐assigned health utility values for controlled and uncontrolled pemphigus vulgaris and foliaceus

Hajdu

Brodszky

Stalmeier

et al. 2019

Acad Dermatol Venereol

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Background The assessment of health‐related quality of life (HRQoL) in patients with pemphigus is now of increasing interest due to the availability of highly effective new therapies. Preference‐based HRQoL values or health utilities required for medical and financial decision‐making are not yet available directly from pemphigus patients. Objective To obtain health utility values for current health and hypothetical health states from the perspective of pemphigus patients. Methods A cross‐sectional questionnaire survey was carried out with pemphigus patients. Disease severity was rated by Autoimmune Bullous Skin Disorder Intensity Score (ABSIS). Patients were asked to evaluate their current health as well as three common hypothetical pemphigus health states [uncontrolled pemphigus vulgaris (PV), uncontrolled pemphigus foliaceus (PF) and controlled PV/PF] by using composite time trade‐off (cTTO). Multiple regression was applied to explore determinants of utility values. Results Responses of 108 patients (64.8% women, mean age 57.4 years) were analysed. Mean ABSIS score was 11.6. The mean utility values for the hypothetical uncontrolled PV, uncontrolled PF and controlled PV/PF health states were 0.41, 0.52 and 0.66 with cTTO. The mean cTTO scores for current health were higher compared with the hypothetical health states (0.76; P < 0.001). Patients with higher ABSIS, worse pain intensity scores and those having a caregiver reported lower utility values for current health (P < 0.05). Conclusions In pemphigus, HRQoL impairment expressed in utility values seems to be considerable, especially in comparison with other chronic dermatological conditions (e.g. psoriasis, atopic eczema, chronic hand eczema). These health utilities inform physicians, policymakers and funders about the overall extent of health loss in pemphigus and provide evidence to guide medical decisions and cost‐effectiveness analyses of treatment strategies. Future research is needed to evaluate the caregiver burden in pemphigus.

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“…For DLQI scoring, the dictum is higher the score, more is the impairment of QoL. Sung JY et al had analysed QoL in pemphigus patients and he found that DLQI score which was high during active disease was quite low during the disease remission phase because of treatment with steroids [18]. Using student's paired 't' test, it was also found that the mean difference between the two was highly significant (P value < 0.0001).…”

Section: Original Research Articlementioning

confidence: 99%

Evaluation of corticosteroid use in outpatient department of dermatology of a tertiary care teaching hospital: a prospective observational study

2019

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Background: Corticosteroids are widely prescribed drugs in dermatology. Rational prescribing of steroids is important for best therapeutic outcome at lowest possible dose. A study was carried out at a tertiary care teaching hospital in order to evaluate the use of corticosteroids which provided a picture of trends in the usage of corticosteroids in dermatology at that setup. Materials and Methods: This prospective, observational study was carried out in department of dermatology for 1 year after ethical approval. Data was analysed for parameters related to corticosteroids, their potency, WHO drug prescribing indicators, effectiveness as well as effects of corticosteroids on quality of life of patients. Statistical analysis was done using Microsoft Excel Office 365. Results: In the 223 patients, 44.84% patients belonged to 21-40 years age group. Most common indication was eczema in 29.15% cases. Topical betamethasone (25.11%) and oral prednisolone (20.17%) were most frequently prescribed. 95/140 topical steroids prescribed were super highly potent. Among concomitant drugs, a majority of 38% were antihistaminics. Degree of polypharmacy showed 04 drugs in a majority (43.15%) of prescriptions. Only 6.27% drugs were prescribed by generic name. Conclusion: Corticosteroids were beneficial to a large no. of patients. Initial usage of low potency steroids topically wherever possible can be emphasized. WHO drug prescribing indicators analysis indicated the need to adhere to WHO guidelines as well as prescribing drugs by generic name. To maintain a balance between judicious use and frequent abuse with corticosteroid is important along with physician's vigilance and patient education.

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Quality of Life Assessment in Korean Patients with Pemphigus

Cited by 20 publications

References 20 publications

Validity of the EQ ‐5D in patients with pemphigus vulgaris and pemphigus foliaceus

Validity of the EQ ‐5D in patients with pemphigus vulgaris and pemphigus foliaceus

Patient‐assigned health utility values for controlled and uncontrolled pemphigus vulgaris and foliaceus

Evaluation of corticosteroid use in outpatient department of dermatology of a tertiary care teaching hospital: a prospective observational study

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