Quality of life, emotion dysregulation, attention deficit and psychiatric comorbidity in children and adolescents with vitiligo

Abstract

Background. To date there is limited literature on the prevalence of chronic skin conditions and its association with levels of physical activity (PA) in Spain. Aim. To determine the prevalence of chronic skin disease and to compare levels of PA between people with and without chronic skin disease in a large representative sample of Spanish adults aged 15-69 years. Methods. Data from the Spanish National Health Survey 2017 were analysed. Chronic skin disease was assessed using a yes/no question. PA was measured using the short form of the International Physical Activity Questionnaire. Total PA metabolic equivalent of task min/week were calculated, and PA was included in the analyses as a continuous and a five-category variable. Results. This cross-sectional study included 17 777 adult participants (52.0% women; mean AE SD age 45.8 AE 14.1 years), of whom 940 (5.3%) had chronic skin disease. After adjusting for several potential confounders, there was a negative association between chronic skin disease and PA (OR = 0.87, 95% CI 0.76-1.00, P = 0.05), which was significant for men (OR = 0.76, 95% CI 0.62-0.93, P = 0.01) but not for women (OR = 0.97, 95% CI 0.81-1.16, P = 0.72). Conclusions. In this large representative sample of Spanish adults, the prevalence of chronic skin disease was low. Levels of PA were lower in men with than in men without chronic skin conditions, but this association was not seen in women.

Meta-Analytic Review of High Anxiety Comorbidity among Patients with Vitiligo

“…The sample sizes of participants ranged from 24 to 1432 people, and gender information was also presented. The mean age in all of the studies except for that by Ucuz et al [ 18 ] ranged from 24.6 to 47.1 years. Ten screening scales were applied to evaluate the prevalence of anxiety.…”

“…Six case-control studies reported data about the prevalence of anxiety in both vitiligo patients and healthy controls [ 9 , 10 , 18 – 21 ]. The pooled OR for the prevalence of anxiety between the two groups was 6.14 (95% CI: 3.35–11.24; P < 0.001), which demonstrated the association between anxiety and vitiligo.…”

“…Nineteen studies [ 8 – 10 , 18 – 23 , 26 – 35 ] reported data about the prevalence of anxiety in patients with vitiligo via diversified outcome measurement tools. The pooled prevalence of anxiety was 23% (95% CI: 16%–30%) ( Figure 4(a) ).…”

“…As considerable heterogeneity ( I 2 = 95.1%; P < 0.001) was observed for the pooled prevalence of anxiety, subgroup analysis was performed based on outcome measurement tools. The pooled prevalence of clinical anxiety disorders based on clinical diagnostic criteria among 9 studies [ 9 , 18 , 21 – 23 , 26 , 28 , 33 , 34 ] was 12% (95% CI: 7%–16%) with heterogeneity ( I 2 = 76.3%; P < 0.001), and that of anxiety symptoms based on valid screening scales among 10 studies [ 8 , 10 , 19 , 20 , 27 , 29 – 32 , 35 ] was 34% (95% CI: 21%–46%) with heterogeneity ( I 2 = 94.7%; P < 0.001).…”

“…Anxiety and depression are the most frequent psychological defects among vitiligo patients [ 11 ]. Compared to depression, anxiety disorder seems to be more prominent in young patients with vitiligo [ 18 , 48 ]. Given that the severity and activity of diseases are positively correlated with the prevalence of anxiety, all dermatologists should put a premium on the impact of anxiety and other psychological burden on patients with vitiligo [ 8 ].…”