Quality-of-life evaluation for patients submitted to nasal endoscopic surgery for resection of pituitary tumours

Dolci, Ricardo Landini Lutaif; Moraes, Lígia Tédde de; Carvalho, Ana Carolina Mayor de; Rickli, Jeniffer Cristina Kozechen; Souza, Jamile Lopes de; Encinas, Williams Escalante; Lima, Jose Viana; Scalissi, Nilza Maria; Santos, Américo Rubens Leite dos; Lazarini, Paulo Roberto

doi:10.1007/s00405-020-06381-1

Cited by 8 publications

(8 citation statements)

References 40 publications

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“…4 ). A review of the available literature shows that quality of life after endoscopic skull base surgery presents to be largely good [ 18 , 19 , 34 , 48 ]. In some cases, restrictions are described in the first few months after surgery, mainly related to a reduced smell function which usually improves over time.…”

Section: Discussionmentioning

confidence: 99%

“…This remodeling can have a negative effect on nasal function and might cause significant subjective discomfort for the patient. In some publications, the patients’ quality of life after such interventions is surveyed using questionnaires [ 16 – 19 ]. On one hand, however, specific negative factors are often missing with these instruments, on the other hand, they are lacking of objective functional parameters in addition to subjective symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Endoscopic trans-sphenoidal pituitary surgery does not impact postoperative nasal quality of life

Weiland,

Gellner,

Pondorfer

et al. 2023

Eur Arch Otorhinolaryngol

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Purpose The aim of this prospective longitudinal study was to assess both subjective quality of life using questionnaires and objective examination of nasal function with regard to olfaction, nasal air flow and mucociliary clearance in patients after minimally invasive, turbinate-preserving endoscopic transnasal trans-sphenoidal pituitary surgery. Methods Patients undergoing endoscopic transnasal pituitary surgery were recruited prospectively and examined during three study visits, preoperatively and 3 and 6 months postoperatively. We examined nasal function using sniffin' sticks test, rhinomanometry, saccharin transit time test, and endoscopic and radiological scores. In addition, the influence on subjective quality of life and mental health was recorded using the Sinonasal-Outcome-Test-20 (SNOT-20) and the Hospital-Anxiety-and-Depression-Scale (HADS). Results 20 patients undergoing endoscopic pituitary tumor resections were included. No significant changes in olfaction or mucociliary clearance were noted. Nasal air flow showed a tendency to increase in the postoperative course lacking significance. Both the endoscopy and the radiological scores showed a significant deterioration, especially after 3 months, with a trend towards improvement over time. However, neither the SNOT-20 nor the HADS showed significant changes compared to baseline. Conclusions Our concept of minimally invasive endoscopic tumor resections on the pituitary gland with preservation of nasal turbinates shows low morbidity for the patient. Despite objectifiable surgery-associated changes in the nose, nasal physiology in terms of smell, airflow and mucociliary clearance can be preserved and the subjective quality of life of our patients remains stable.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endoscopic trans-sphenoidal pituitary surgery does not impact postoperative nasal quality of life

Weiland,

Gellner,

Pondorfer

et al. 2023

Eur Arch Otorhinolaryngol

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“…Awareness of these problems by the medical staff and family members may benefit the long‐term follow‐up and prognosis and should take it into mind when discussing treatment options and long‐term outcome with patients (Zhu et al, 2021 ). Psychological comfort, social support and effective rehabilitation guidance, detailed health education should be resorted to reduce the physical and psychological burden of patients with pituitary tumours (Dolci et al, 2021 ; Marx et al, 2021 ), and it is recognized that overwhelmingly avoided, resignated coping may make a negative impact on the disease, while appropriately guiding patients to take more active coping strategies are necessary.…”

Section: Discussionmentioning

confidence: 99%

Coping strategies in patients undergoing surgery treatment for pituitary tumour in China: A cross‐sectional survey

Zhang

et al. 2022

Nursing Open

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Pituitary adenomas are benign neoplasms that account for 10%-15% of all diagnosed intracranial tumours, and they are the most common type of pituitary disorder (Castellanos, Gutierrez et al., 2021;Di Somma et al., 2021;Famini et al., 2011). Pituitary adenomas may result in considerable adverse consequences such as hormone overproduction and tumour mass effects, thus the physical and psychological conditions of patients may comprised and the quality of life (QoL) (Biamonte et al., 2021;Castellanos, Misra et al., 2021;Dallel et al., 2021). The impairment of QoL have been ensured in patients in biochemical remission of Cushing's disease (CD), non-functioning macroadenoma (NFA), acromegaly (ACRO) and prolactinoma (PRL)

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“…We could not prove a significant change in QoL in NFPA patients following TSS, despite the fact that the effects of surgery in our group were not inferior to other studies. Results from other prospective observational studies analyzing the effects of TSS on QoL in patients with sellar masses, including NFPAs, are inconsistent, revealing very good improvements [ 38 , 39 ], moderate improvements [ 40 , 41 , 42 ], or no improvements [ 43 ]. Interestingly, Tanemura et al reported that NFPA patients who required hormonal substitution scored much lower on the SF-36v2 scale postoperatively and most likely have worse prognosis for improvement [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Quality of Life and Sleep in Patients with Pituitary Adenoma in Relation to Tumor Type and Compression of the Optic Chiasm

Sagan

Andrysiak‐Mamos

Tyburski

et al. 2021

JCM

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Objective: To determine the effect of transsphenoidal surgery on quality of life and sleep in patients with pituitary adenomas depending on tumor type and compression of the optic chiasm. Methods: In this prospective study, patients with pituitary adenomas who were scheduled for transsphenoidal surgery completed the Short Form 36 Questionnaire, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale preoperatively and 7.5 (±1.5) months after surgery. Patients were analyzed based on tumor type and compression of the optic chiasm. Results: Significant improvements with large effect sizes were seen for patients with Cushing’s disease in general health (Z = −2.37; p = 0.018), vitality (Z = −2.05; p = 0.041), and mental health (Z = −2.06; p = 0.040). A significant deterioration with large effect size occurred in physical functioning (Z = −2.02; p = 0.043) in patients with acromegaly. A significant improvement with medium effect size was seen in subjective sleep quality, (Z = −2.24; p = 0.025), sleep duration (Z = −2.11; p = 0.035), and habitual sleep efficiency (Z = −2.26; p = 0.024) after decompression of the optic chiasm. Multiple significant correlations were observed between sleep parameters and Short Form 36 subscales before and after treatment. Conclusions: Changes in quality of life during the follow-up period depend on tumor type. Circadian rhythm disturbances may resolve promptly after decompression of the optic chiasm. Quality of life in pituitary adenoma patients is associated with quality of sleep in many dimensions, thus implying that developing strategies to improve sleep quality could increase overall well-being and everyday functioning in pituitary adenoma patients.

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Quality-of-life evaluation for patients submitted to nasal endoscopic surgery for resection of pituitary tumours

Cited by 8 publications

References 40 publications

Endoscopic trans-sphenoidal pituitary surgery does not impact postoperative nasal quality of life

Endoscopic trans-sphenoidal pituitary surgery does not impact postoperative nasal quality of life

Coping strategies in patients undergoing surgery treatment for pituitary tumour in China: A cross‐sectional survey

Quality of Life and Sleep in Patients with Pituitary Adenoma in Relation to Tumor Type and Compression of the Optic Chiasm

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