Quality of life following cord blood versus matched sibling donor transplantation: pre-transplantation psychiatric and socioeconomic factors significantly impact outcomes

Brewer, Benjamin W.; Sharma, Prashant K.; Gakhar, Neel; Sannes, Timothy S.; Joshi, Tanisha K.; Hunter, Rebecca; Abbott, Diana; Gutman, Jonathan A.

doi:10.1038/s41409-022-01721-7

Cited by 5 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The survival outcomes of UCBT (without the use of ATG) and peripheral blood MUD transplantation, both using MAC regimens, were similar in a multicenter study conducted in China, but UCBT was associated with better QoL and lower incidence of chronic GvHD. 41 To assess the quality of life of patients surviving for 2 years, Karnofsky performance score (KPS) was used. The post-transplant KPS of UCBT recipients was higher than that of unrelated peripheral blood HSCT recipients.…”

Section: Improving the Efficacy Of Ucbtmentioning

confidence: 99%

“…An additional study assessed multiple measures of QoL after 1 year of HSCT, including functional assessment, fatigue, anxiety, depressive symptoms, suicidal thoughts, and sleep quality. 41 UCB and MRD transplantation were compared in terms of QoL. Patients in the UCBT group were more likely to have longer hospital stays, receive more MAC regimens, experience less chronic GvHD, and take less immunosuppressants at the time of the survey.…”

Section: Improving the Efficacy Of Ucbtmentioning

confidence: 99%

“…In this study, low TERS scores (a tool used to assess the mental health and well-being of patients before transplantation) were independently and strongly correlated with post-transplant results: UCBT patients scored higher on TERS than MRD patients, and chronic GvHD patients scored lower. 41 , 42 As a limitation of this study, a one-time survey was used rather than serial assessments at standardized intervals following transplantation. In assessing QoL among donor sources, the authors acknowledge that developing strategies to minimize chronic GvHD are likely to positively impact QoL.…”

Section: Improving the Efficacy Of Ucbtmentioning

confidence: 99%

“…In assessing QoL among donor sources, the authors acknowledge that developing strategies to minimize chronic GvHD are likely to positively impact QoL. 41 …”

Section: Improving the Efficacy Of Ucbtmentioning

confidence: 99%

See 3 more Smart Citations

Umbilical Cord Blood Transplantation: Connecting Its Origin to Its Future

Sanchez‐Petitto

Rezvani

Daher

et al. 2023

Stem Cells Translational Medicine

View full text Add to dashboard Cite

Transplantation of umbilical cord blood (UCB) is an attractive alternative source of hematopoietic stem cells (HSCs). The unique properties of cord blood and its distinct immune tolerance and engraftment kinetics compared to bone marrow (BM) and peripheral blood progenitor cells, permit a wider disparity in human leukocyte antigen levels between a cord blood donor and recipient after an unrelated umbilical cord blood transplant (UCBT). In addition, it is readily available and has a lowered risk of graft-versus-host disease (GvHD), with similar long-term clinical outcomes, compared to BM transplants. However, the relatively low number of cells administered by UCB units, as well as the associated delayed engraftment and immune reconstitution, pose limitations to the wide application of UCBT. Research into several aspects of UCBT has been evaluated, including the ex vivo expansion of cord blood HSCs and the process of fucosylation to enhance engraftment. Additionally, UCB has also been used in the treatment of several neurodegenerative and cardiovascular disorders with varying degrees of success. In this article, we will discuss the biology, clinical indications, and benefits of UCBT in pediatric and adult populations. We will also discuss future directions for the use of cord blood.

show abstract

Section: Improving the Efficacy Of Ucbtmentioning

confidence: 99%

Section: Improving the Efficacy Of Ucbtmentioning

confidence: 99%

Section: Improving the Efficacy Of Ucbtmentioning

confidence: 99%

“…In assessing QoL among donor sources, the authors acknowledge that developing strategies to minimize chronic GvHD are likely to positively impact QoL. 41 …”

Section: Improving the Efficacy Of Ucbtmentioning

confidence: 99%

See 2 more Smart Citations

Umbilical Cord Blood Transplantation: Connecting Its Origin to Its Future

Sanchez‐Petitto

Rezvani

Daher

et al. 2023

Stem Cells Translational Medicine

View full text Add to dashboard Cite

show abstract

“…Although ancestry 1 , 2 , 3 , 4 and socioeconomic status 5 , 6 , 7 (SES) both affect allogeneic transplant care delivery, the association between these variables and their interaction with stem cell donor type are not established. Given that patients from historically marginalized groups are more likely to have lower SES 8 and face financial hardship compared with other patients, 9 , 10 and because non-European ancestry patients are more likely to lack an 8/8 human leukocyte antigen (HLA)-matched unrelated donor (URD) compared with their European counterparts, 1 , 4 we hypothesized that low SES disproportionately affects non-European recipients of HLA-disparate grafts (cord blood [CB], haploidentical, or 4/8 to 7/8 mismatched URD [mmURD] grafts).…”

mentioning

confidence: 99%

Association between non-European ancestry, low socioeconomic status, and receipt of HLA-disparate allografts in adult BMT recipients

et al. 2023

View full text Add to dashboard Cite

Psychosocial assessment practices for hematopoietic stem cell transplantation: a national survey study

Wiener,

Sannes,

Randall

et al. 2023

Bone Marrow Transplant

Self Cite

View full text Add to dashboard Cite

Psychosocial health predicts and contributes to medical outcomes for patients undergoing hematopoietic stem cell transplantation (HSCT). Yet, there are no standards for psychosocial assessments or support for both patients and caregivers across the care continuum. To examine the current state of psychosocial care, clinicians were sent a survey of their psychosocial assessment practices for patients and caregivers undergoing HSCT via the Listservs of professional organizations. Descriptive statistics and bivariate analyses were performed to summarize the ndings. While 96% of participants reported routine pre-HSCT psychosocial assessment of patients, only 10.6% routinely used a validated transplant risk-assessment measure. Just 27% routinely performed follow-up psychosocial assessments. In contrast, only 47% of participants routinely assessed the psychosocial needs of family caregivers pre-HSCT, and 13% routinely performed follow-up assessments for caregivers. Most (90%) reported social workers were the primary providers of assessments. While patient-report measures were used for evaluation, the majority of assessments were clinical interviews. No signi cant differences were found between programs that treated adult and pediatric patients versus those only treating adult patients. Our ndings highlight the lack of standard psychosocial practices for patients and family caregivers undergoing HSCT and we offer recommendations to ll this gap.

show abstract

Quality of life following cord blood versus matched sibling donor transplantation: pre-transplantation psychiatric and socioeconomic factors significantly impact outcomes

Cited by 5 publications

References 12 publications

Umbilical Cord Blood Transplantation: Connecting Its Origin to Its Future

Umbilical Cord Blood Transplantation: Connecting Its Origin to Its Future

Association between non-European ancestry, low socioeconomic status, and receipt of HLA-disparate allografts in adult BMT recipients

Psychosocial assessment practices for hematopoietic stem cell transplantation: a national survey study

Contact Info

Product

Resources

About