Quality of Life Following Major Laparoscopic or Open Pancreatic Resection

Torphy, Robert J.; Chapman, Brandon C.; Friedman, Chloe; Nguyen, Christina; Bartsch, Christan; Meguid, Cheryl; Ahrendt, Steven A.; McCarter, Martin D.; Chiaro, Marco Del; Schulick, Richard D.; Edil, Barish H.; Gleisner, Ana

doi:10.1245/s10434-019-07449-x

Cited by 29 publications

(23 citation statements)

References 21 publications

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“…Sixty-one of the 62 respondents (98%) completed the body image and cosmetic satisfaction questions after median follow-up of 44 months. Body image did not differ significantly between MIDP and ODP (median 6 [IQR 5-13] versus [7][8][9][10][11][12][13][14][15][16][17][18][19][20], p = 0.15). Patients in the MIDP group reported higher cosmetic satisfaction scores (21)(22)(23)(24) versus [14][15][16][17][18][19][20][21][22][23][24], p = 0.049), higher overall scar score (9 [IQR 3-10] versus 6 [IQR 0-10], p = 0.026), and higher scar description scores (6)(7) versus 4 [IQR 1-7], p = 0.042).…”

Section: Cosmetic Satisfaction Outcomesmentioning

confidence: 99%

“…[5][6][7] Since pancreatic surgery has significant impact on QoL during the early postoperative stages, it seems worthwhile to assess the influence of MIDP on QoL. [8][9][10] The multicenter LEOPARD trial found improved shortterm QoL following MIDP, as compared to ODP, up to 30 days postoperatively. 4 This benefit, however, was no longer present at one-year follow-up.…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Quality of Life after Minimally Invasive vs Open Distal Pancreatectomy in the LEOPARD Randomized Trial

Korrel

Roelofs

Hilst

et al. 2021

Journal of the American College of Surgeons

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Cosmetic Satisfaction Outcomesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long-Term Quality of Life after Minimally Invasive vs Open Distal Pancreatectomy in the LEOPARD Randomized Trial

Korrel

Roelofs

Hilst

et al. 2021

Journal of the American College of Surgeons

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“…Furthermore, the traditional prediction models for POPF or CR-POPF provide results that stay constant regardless of the patients' fluctuating state over time. Developing a dynamic prediction model for CR-POPF will provide us a prediction result that could be rectify according to the fluctuations of the examination results and patients' conditions, especially after the patients experienced visceral dissection and reconstruction as well as loss and recovery of visceral function [1,29], when the homeostasis of the cases fluctuates rapidly [24,25]. And, it could offer us timely predictions of the patients' risk of developing of CR-POPF, which could contribute to making personalized treatment decisions with less deviation [30].…”

Section: Discussionmentioning

confidence: 99%

Dynamic prediction for clinically relevant pancreatic fistula: a novel prediction model for laparoscopic pancreaticoduodenectomy

Liu

Cai

et al. 2021

BMC Surg

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Background With the recent emerge of dynamic prediction model on the use of diabetes, cardiovascular diseases and renal failure, and its advantage of providing timely predicted results according to the fluctuation of the condition of the patients, we aim to develop a dynamic prediction model with its corresponding risk assessment chart for clinically relevant postoperative pancreatic fistula after laparoscopic pancreaticoduodenectomy by combining baseline factors and postoperative time-relevant drainage fluid amylase level and C-reactive protein-to-albumin ratio. Methods We collected data of 251 patients undergoing LPD at West China Hospital of Sichuan University from January 2016 to April 2019. We extracted preoperative and intraoperative baseline factors and time-window of postoperative drainage fluid amylase and C-reactive protein-to-albumin ratio relevant to clinically relevant pancreatic fistula by performing univariate and multivariate analyses, developing a time-relevant logistic model with the evaluation of its discrimination ability. We also established a risk assessment chart in each time-point. Results The proportion of the patients who developed clinically relevant postoperative pancreatic fistula after laparoscopic pancreaticoduodenectomy was 7.6% (19/251); preoperative albumin and creatine levels, as well as drainage fluid amylase and C-reactive protein-to-albumin ratio on postoperative days 2, 3, and 5, were the independent risk factors for clinically relevant postoperative pancreatic fistula. The cut-off points of the prediction value of each time-relevant logistic model were 14.0% (sensitivity: 81.9%, specificity: 86.5%), 8.3% (sensitivity: 85.7%, specificity: 79.1%), and 7.4% (sensitivity: 76.9%, specificity: 85.9%) on postoperative days 2, 3, and 5, respectively, the area under the receiver operating characteristic curve was 0.866 (95% CI 0.737–0.996), 0.896 (95% CI 0.814–0.978), and 0.888 (95% CI 0.806–0.971), respectively. Conclusions The dynamic prediction model for clinically relevant postoperative pancreatic fistula has a good to very good discriminative ability and predictive accuracy. Patients whose predictive values were above 14.0%, 8.3%, and 7.5% on postoperative days 2, 3, and 5 would be very likely to develop clinically relevant postoperative pancreatic fistula after laparoscopic pancreaticoduodenectomy.

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“…In an analysis of patients undergoing pancreatic operations, physical and functional quality of life were often below preoperative levels for weeks to months after their operation. 68 Physicians assess patients' personal networks and those judgments can shape clinical decisionmaking. 69 This may make them less likely to recommend operations for patients with pancreatic cancer experiencing homelessness out of concern about postoperative complications.…”

Section: Community and Regional Interventions For Patients Experiencing Homelessnessmentioning

confidence: 99%

Providing Appropriate Pancreatic Cancer Care for People Experiencing Homelessness: A Surgical Perspective

Louie

Nwaiwu

Rozenberg

et al. 2021

American Society of Clinical Oncology Educational Book

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People experiencing homelessness are particularly vulnerable when diagnosed with pancreatic cancer. Patients with lower socioeconomic status have worse outcomes from pancreatic cancer as the result of disparities in access to treatment and barriers to navigation of the health care system. Patients with lower socioeconomic status, or who are vulnerably housed, are less likely to receive surgical treatment even when it is recommended by National Comprehensive Cancer Network guidelines. This disparity in access to surgical care explains much of the gap in pancreatic cancer outcomes. There are many factors that contribute to this disparity in surgical management of pancreatic cancer in people experiencing homelessness. These include a lack of reliable transportation, feeling unwelcome in the medical setting, a lack of primary care and health insurance, and implicit biases of health care providers, including racial bias. Solutions that focus on rectifying these problems include utilizing patient navigators, addressing implicit biases of all health care providers and staff, creating an environment that caters to the needs of patients experiencing homelessness, and improving their access to insurance and regional support networks. Implementing these potential solutions all the way from the individual provider to national safety nets could improve outcomes for patients with pancreatic cancer who are experiencing homelessness.

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Quality of Life Following Major Laparoscopic or Open Pancreatic Resection

Cited by 29 publications

References 21 publications

Long-Term Quality of Life after Minimally Invasive vs Open Distal Pancreatectomy in the LEOPARD Randomized Trial

Long-Term Quality of Life after Minimally Invasive vs Open Distal Pancreatectomy in the LEOPARD Randomized Trial

Dynamic prediction for clinically relevant pancreatic fistula: a novel prediction model for laparoscopic pancreaticoduodenectomy

Providing Appropriate Pancreatic Cancer Care for People Experiencing Homelessness: A Surgical Perspective

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