Quality of life following thoracotomy for lung cancer

Debevec, Lučka; Rozman, I.M.

doi:10.2478/v10019-007-0023-8

Cited by 2 publications

(2 citation statements)

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“…The remaining 314 records dealt with the LC13; however, of these, 74 records were excluded because they did not present original data obtained by means of the module. Consequently, n = 240 articles were considered clinical studies according to our definition and were included in further analyses …”

Section: Resultsmentioning

confidence: 99%

Use of the lung cancer–specific Quality of Life Questionnaire EORTC QLQ‐LC13 in clinical trials: A systematic review of the literature 20 years after its development

Koller

Warncke

Hjermstad

et al. 2015

Cancer

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13 (QLQ-LC13) covers 13 typical symptoms of lung cancer patients and was the first module developed in conjunction with the EORTC core qualityof-life (QL) questionnaire. This review investigates how the module has been used and reported in cancer clinical trials in the 20 years since its publication. Thirty-six databases were searched with a prespecified algorithm. This search plus an additional hand search generated 770 hits, 240 of which were clinical studies. Two raters extracted data using a coding scheme. Analyses focused on the randomized controlled trials (RCTs). Of the 240 clinical studies that were identified using the LC13, 109 (45%) were RCTs. More than half of the RCTs were phase 3 trials (n 5 58). Twenty RCTs considered QL as the primary endpoint, and 68 considered it as a secondary endpoint. QL results were addressed in the results section of the article (n 5 89) or in the abstract (n 5 92); and, in half of the articles, QL results were presented in the form of tables (n 5 53) or figures (n 5 43). Furthermore, QL results had an impact on the evaluation of the therapy that could be clearly demonstrated in the 47 RCTs that yielded QL differences between treatment and control groups. The EORTC QLQ-LC13 fulfilled its mission to be used as a standard instrument in lung cancer clinical trials. An update of the LC13 is underway to keep up with new therapeutic trends and to ensure optimized and relevant QL assessment in future trials.

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Section: Resultsmentioning

confidence: 99%

Use of the lung cancer–specific Quality of Life Questionnaire EORTC QLQ‐LC13 in clinical trials: A systematic review of the literature 20 years after its development

Koller

Warncke

Hjermstad

et al. 2015

Cancer

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“…None of the published studies on QoL following thoracotomy in lung cancer patients using the EORTC questionnaire [2][3][4] reported such a finding. From February 2004 to July 2005, we performed a similar study using the same questionnaire [5]. In 43 patients, 62 years of age on average (range 31-82), thoracotomized (lobectomy 29, bilobectomy 1, pneumonectomy 8 and explorative thoracotomy without resection 5) for non-small cell lung cancer, pathological (in explored patients, surgical) stage IA 13, stage IB 9, stage IIA 3, stage IIB 8, stage IIIA 5, stage IIIB 4 and stage IV 1 patient, QoL was measured pre-operatively and at an average of 45 days after thoracotomy, before eventual chemotherapy or radiation therapy.…”

mentioning

confidence: 99%