Quality of Life for Children and Adolescents: Impact of HIV Infection and Antiretroviral Treatment

Lee, Grace M.; Gortmaker, Steven L.; McIntosh, Kenneth; Hughes, Michael D.; Oleske, James M.; Palumbo, Paul; Andrew, P. Kinziger; Dieudonne, Arry; Dashefsky, Barry; Gaur, Sunanda; Whitley-Williams, Patricia; Malhotra, Amisha; Cerracchio, L.; Keller, Margaret; Hayes, J.; Gagajena, A.; Mink, ChrisAnna M.; Hutton, Nancy; Griffith, Brigitte P.; Joyner, Mary; Kiefner, C.; Minglana, F.; Paul, Mary E.; Shearer, William T.; Jackson, Cindy; Johnson, Dorothea; Kowalski, Dorothee; Wolfe, Brenda; Ryan, Daniel T.; Higgins, Abigail; Foca, Marc; LaRussa, Philip; Gershon, Anne A.; Scott, Gwendolyn B.; Mitchell, Charles D.; Taybo, L.; Gamber, C.; Petru, Ann; Courville, Teresa; Gold, Karen; Johnson, Lisette; Piatt, Jan; Foti, Jeffrey; Clarke-Steffen, Laura; Belho, T.; Pitkin, B.; Eddleman, Joanne Stone Keith; Bonagura, V.R.; Schuval, Susan; Colter, C.; Abrams, Elaine J.; Frere, M.; Calo, D.; Champion, Sue; Handelsman, Edward; Moallem, Hamid; Swindell, D. M.; Kaye, Jean; Chin, M.; Dorio, K.; Wiznia, Andrew; Donovan, Michael; Acevedo, Michelle Laurens; González, Mercedes; Fábregas, Lizbeth; Texidor, M. E.; Andiman, Warren A.; Romano, Sostena; Hurst, Leslie; Jesus, J. De; Weiner, Leonard B.; Contello, Kathie A.; Holz, Wendy A.; Famiglietti, Marylinda; Nachman, Sharon; Nikolic-Djokic, Divna; Ferraro, Denise; Perillo, J.; Rana, Sohail; Finke-Castro, H.; Yu, Pei; Roa, Jhoanna; Rathore, Mobeen H.; Khayat, Abeer; Champion, Karine; Cusic, S.; Flynn, Patricia M.; Knapp, Katherine M.; Patel, Nehali; Wilson, Gregory J.; McGann, Kathleen A.; Pickering, Larry K.; Storch, Gregory A.; Douglas, Steven D.; Koutsoubis, G.; Rutstein, Richard M.; Vincent, Carol; Silio, Margarita; Alchediak, T.; Boe, C.; Cowie, Martin R.; Stechenberg, Barbara W.; Fisher, Donna; Johnston, Alicia; Toye, Maripat; Mani, Chitra S.; Foshee, S.; Kiean, B.; Cobb, Sharon; Farley, John; Klipner, K.

doi:10.1542/peds.2005-0323

Cited by 79 publications

(75 citation statements)

References 18 publications

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“…14 The baseline QOL, before ART, of these children has been previously reported showing relatively low QOL scores compared to previous reports from untreated HIV-infected children in Western countries, and also lower than ART-treated Thai HIV-infected children from Northern Thailand. 3,13,15 Higher CD4% and CD4 cell count were associated with higher QOL scores in the health perception domain in Thai and Cambodian HIV-infected children. 13 Here, we report the effect of ART initiation on QOL in children over 144 weeks in the PREDICT study.…”

Section: Introductionmentioning

confidence: 92%

“…7 Unlike many other chronic illnesses, children with HIV infection are more likely to experience more difficulties in their daily lives (e.g., parental death from AIDS and social stigmatization 8,9 ) which may worsen their QOL. Lee et al 3 reported significantly lower QOL scores in HIV-infected children as compared to HIV-exposed but uninfected children. In addition, long-term requirement for life-saving antiretroviral therapy (ART) with pill burden and its side effects may affect children's QOL.…”

Section: Introductionmentioning

confidence: 97%

“…Living with a chronic illness can affect children's QOL. [1][2][3] Currently, HIV-infected children treated with highly active antiretroviral therapy (HAART) have increased life expectancy. [4][5][6] Deaths related to HIV/AIDS mortality have decreased significantly, but the non-AIDSrelated conditions maintain a stable trend in children living with HIV-1 after treatment with HAART.…”

Section: Introductionmentioning

confidence: 99%

“…The majority of QOL reports in HIV-infected children were from resource-rich settings, and conducted as cross-sectional studies in children already treated with ART. 3,[10][11][12] There are limited data of QOL change before and after ART initiation in HIV-infected children without AIDS symptoms. 13 Our team has conducted a multicenter, randomized, openlabel study of early versus deferred ART among Thai and Cambodian ART-naïve HIV-infected children with CD4 15-24% (Pediatric Randomized of Early vs.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Impact of Antiretroviral Therapy on Quality of Life in HIV-Infected Southeast Asian Children in the PREDICT Study

Bunupuradah

Kosalaraksa²,

Vibol³

et al. 2013

AIDS Patient Care and STDs

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Quality of life (QOL) is an important antiretroviral treatment (ART) outcome. We compared QOL among 299 Thai and Cambodian children ages 1-12 years-old, CD4 15-24% randomized to early (ART at week 0, N = 149) versus deferred groups (ART when at CD4 < 15%, N = 150) and also compared with QOL data from age-matched healthy controls (N = 275). Primary caregivers completed PACTG QOL questionnaires at week 0 and every 24 weeks until 144 weeks. Children were enrolled during March 2006 to September 2008. Mean (SD) age of children was 6.3 (2.8) years, 58% were female, 60% were Thai, %CDC N:A:B:C was 2:62:36:0%. During 144 weeks, all children in the early-group and 69 (46%) of deferred-group children started ART. There was no significant difference of QOL scores between treatment groups at baseline (all p > 0.05) and at week 144 (all p > 0.05). By multivariate analysis, the early-group had higher QOL score changes in five domains, including health perception ( p = 0.04), physical resilience ( p = 0.02), psychosocial well-being ( p = 0.04), social and role functioning ( p < 0.01), and symptoms ( p = 0.01) compared to the deferred group. QOL of HIV-infected children in both groups were lower than healthy control in all 7 domains at baseline (all p < 0.05) and 5 of 7 domains at weeks 144 ( p < 0.01). In conclusion, no significant difference of QOL scores between treatment groups. Early ART commencement associated with greater increase of QOL scores over 144 weeks. QOL scores in HIV-infected children were lower than healthy controls.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of Antiretroviral Therapy on Quality of Life in HIV-Infected Southeast Asian Children in the PREDICT Study

Bunupuradah

Kosalaraksa²,

Vibol³

et al. 2013

AIDS Patient Care and STDs

View full text Add to dashboard Cite

show abstract

“…The questionnaire is based on a multidimensional conceptualization of health perceptions, physical resilience, physical functioning, psychological, social/role functioning, health care utilization and HIV-symptoms. This questionnaire was used in studies with HIV/AIDS infected children and has presented evidence of validity in this population 4,5,6 .…”

Section: Introductionmentioning

confidence: 99%

Health Related Quality of Life Assessment questionnaire for children aged 5 to 11 years with HIV/AIDS: cross-cultural adaptation for the Portuguese language

Costa

Latorre

Hearst³

et al. 2011

Cad. Saúde Pública

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The objective of this study is to describe preliminary results from the cross-cultural adaptation of the Quality of Life Assessment Questionnaire, used to measure health related quality of life (HRQL) in Brazilian children aged between 5 and 11 with HIV/AIDS. The cross-cultural model evaluated the Concept, Item, Semantic and Measurement Equivalences (internal consistency and intra-observer reliability). Evaluation of the conceptual, item, semantic equivalences showed that the Portuguese version is pertinent for the Brazilian context. Four of seven domains showed internal consistency above 0.70 (α: 0.76-0.90) and five of seven revealed intra-observer reliability (ricc: 0.41-0.70). This first Portuguese version of the HRQL questionnaire can be understood as a valuable tool for assessing children's HRQL, but further studies with large samples and more robust analyses are recommended before use in the Brazilian context.

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Toxic Stress and Quality of Life in Early School‐Aged Ugandan Children With and Without Perinatal Human Immunodeficiency Virus Infection

Ezeamama

Zalwango

Tuke

et al. 2020

New Directions for Child and Adolescent Development

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Caregiver's and child's self‐reported quality of life (QOL) was defined using standardized questionnaires in a sample (N = 277) of 6–10 years old HIV‐infected, HIV‐exposed uninfected, and HIV‐unexposed uninfected children from Uganda. Psychosocial stress (acute stress and cumulative lifetime adversity) and physiologic stress (dysregulations across 13 biomarkers), perinatal HIV status, and their interaction were related to child QOL via general linear models. Lower child‐ and caregiver‐reported psychosocial stress were dose‐dependently associated with higher QOL (acute stress: mean difference coefficient b = 8.1–14.8, effect size [ES] = 0.46–0.83). Lower allostasis was dose‐dependently associated with higher QOL (b = 6.1–9.7, ES = 0.34–0.54). Given low caregiver acute stress, QOL for HIV‐infected was similar to HIV‐uninfected children; however, given high caregiver acute stress, a QOL disadvantage (b = −7.8, 95% CI: −12.8, −2.8; ES = −0.73) was evident for HIV‐infected versus uninfected children. Testing of caregiver stress reduction interventions is warranted to increase wellbeing in dependent children.

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Quality of Life for Children and Adolescents: Impact of HIV Infection and Antiretroviral Treatment

Cited by 79 publications

References 18 publications

Impact of Antiretroviral Therapy on Quality of Life in HIV-Infected Southeast Asian Children in the PREDICT Study

Impact of Antiretroviral Therapy on Quality of Life in HIV-Infected Southeast Asian Children in the PREDICT Study

Health Related Quality of Life Assessment questionnaire for children aged 5 to 11 years with HIV/AIDS: cross-cultural adaptation for the Portuguese language

Toxic Stress and Quality of Life in Early School‐Aged Ugandan Children With and Without Perinatal Human Immunodeficiency Virus Infection

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