Quality of life for elderly breast cancer patients: a new regard

Mahfouz, Mohamed Abdelrahim; Almaghrabi, M.Y.

doi:10.21037/tcr.2019.07.39

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…This study investigated the independent associations between frailty and quality of life, elderly women with breast cancer ic variables on both Frailty and QoL. Mahfouz et al revisited the most used QoL instruments for breast cancer patients across the trials [38]. Recently, Chambergo-Michilot et al used the WHOQOL-OLD Module in their study of male cancer patients [39].…”

Section: Discussionmentioning

confidence: 99%

The Relationships between Frailty and Quality of Life in Elderly Women with Breast Cancer

et al. 2022

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Background: It is well known that oncologic management of elderly patients is complicated, and physicians should well define the ultimate goals when choosing treatment modalities. Cancer treatment should not necessarily focus on survival but aim for a good quality of life for the patient in light of their frailty. Patients and Methods: This is a retrospective cross-sectional survey study. One hundred fifty-eight women with breast cancer participated in this study. The PRISMA-7 Frailty Index and WHOQOL-OLD Module assessed participants’ frailty and quality of life. SPSS 26.0 and Medcalc 14 [Acacialaan 22, B-8400 Ostend, Belgium] programs were used for statistical analyses. Statistically significant associations between the PRISMA-7 scale and the WHOQOL-OLD Module were assessed. Results: Of the158 participants, the median age [min-max] was 71 [65-96] years, and 61.2% had stage I and II breast cancer. Lumpectomy was 61.1%, and 75% received chemotherapy-radiotherapy and hormone therapy. For the WHOQOL-OLD domains; financial status [p=0.001] with the sensory ability domain, work status [p<0.001] and education status[p=0.004] with the autonomy domain, education status [p=0.002] with PPF activity domain, education status [p=0.001] and work status [p=0.007] with the social participation domain, treatment modality [p=0.003] with death &dying domain, number of comorbidities [p=0.004] with intimacy domain statistically significant. The total score was associated with education status [p=0.005] and the number of comorbidities [p=0.010]. Frailty correlated positively with age [cut-off age 68 years; p<0.001]. Education status was inversely associated with increased frailty [p=0.003]. The relationship between the PRISMA-7 scale and the WHOQOL-OLD Module correlated negatively in five out of six dimensions except for the Intimacy domain. Conclusions: It is necessary to design customized cancer management programs to improve specific components of elderly women with breast cancer with increased frailty by revealing the associations in domains of QoL.

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Section: Discussionmentioning

confidence: 99%

The Relationships between Frailty and Quality of Life in Elderly Women with Breast Cancer

et al. 2022

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“…Clinically, the goal of breast cancer treatment is to remove all visible cancer and manage the disease over the long term. Patient health-related quality of life (HRQoL), defined as the patient-perceived psychosocial, emotional and physical outcomes of medical intervention [ 4 ], is another important aspect of breast cancer treatment [ 5 , 6 ]. In particular, patient HRQoL should be considered when a treatment approach is unlikely to improve survival, as in some metastatic cancers.…”

Section: Introductionmentioning

confidence: 99%

Safety and efficacy of spleen aminopeptide oral lyophilized powder for improving quality of life and immune response in patients with advanced breast cancer: a multicenter, randomized, double-blind, placebo-controlled clinical trial

Wang

Ma²,

Shang³

et al. 2021

Anti-Cancer Drugs

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Health-related quality of life (HRQoL) is an important consideration in managing patients. Spleen aminopeptide oral lyophilized powder (SAOLP) has been used to enhance cellular immunity in a patient. This multicenter, randomized, double-blind, placebo-controlled clinical trial was designed to evaluate the safety and efficacy of SAOLP for improving HRQoL in patients with breast cancer. Patients diagnosed with advanced breast cancer were included, and were administered SAOLP or placebo 4 mg qd for two cycles. The primary endpoint was improvement in HRQoL on day 42 measured by the EORTC QLQ-C30 and EORTC QLQ-BR23. Secondary endpoints included immunologic function, improvement in HRQoL on day 21 and 84, objective response rate, disease control rate, BMI and adverse events. On day 42, on the EORTC QLQ-C30 or EORTC QLQ-BR23, scores on the functional scales and QoL scale were significantly higher and scores on symptom scales were significantly lower in patients who received SAOLP compared to placebo ( P < 0.05). On day 84, the number of CD3, CD4 and CD8 cells were significantly higher in patients who received SAOLP. There were no significant differences in objective response rate, disease control rate or BMI. SAOLP may improve HRQoL and the immune response in patients with advanced breast cancer, represents a convenient and safe adjuvant therapy.

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Development and Psychometric Evaluation of the Social Participation Questionnaire: A Methodological and Cross-Sectional Study

Zhao,

Li,

Qin

et al. 2024

Am J Health Promot

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Purpose Social participation is vital for the health maintenance of general populations as well as the functional recovery and social ties of clinical patients. To develop a Social Participation Questionnaire (SPQ) to evaluate participation in social activities in an individual’s life and to test the reliability and validity of the SPQ. Design Cross-sectional study. Setting Community and clinic in China. Subjects A total of 1419 healthy adults and 486 breast cancer patients. Measures The initial items were developed from a theoretical framework, a literature review, and Delphi expert consultation. Item analysis, exploratory (EFA) and confirmatory factor analysis (CFA), criterion validity, construct reliability, and internal consistency reliability were performed to examine the psychometric properties of the SPQ. Results The final SPQ was comprised of 11 different types of social activities, falling under the 3 dimensions of activities of daily life, sports and entertainment activities, and social service activities. EFA explained 50.674% of the total item variance contributing to the tool. CFA showed that the SPQ fit well. The total SPQ score was significantly associated with social network, quality of life, and cognitive function ( r = |.180∼.466|, P < .001). The internal consistency coefficient was acceptable (range of Cronbach’s alpha, .695 to .720). Conclusions The SPQ has robust properties, wide application, and provides a culturally relevant tool to evaluate the social participation of individuals, thus facilitating rigorous clinical and population-based research.

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Quality of life for elderly breast cancer patients: a new regard

Cited by 3 publications

References 22 publications

The Relationships between Frailty and Quality of Life in Elderly Women with Breast Cancer

The Relationships between Frailty and Quality of Life in Elderly Women with Breast Cancer

Safety and efficacy of spleen aminopeptide oral lyophilized powder for improving quality of life and immune response in patients with advanced breast cancer: a multicenter, randomized, double-blind, placebo-controlled clinical trial

Development and Psychometric Evaluation of the Social Participation Questionnaire: A Methodological and Cross-Sectional Study

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