Quality of life, functional status, and persistent symptoms after intensive care of COVID-19 patients

Taboada, Manuel; Moreno, E.; Cariñena, Agustín; Rey, T.; Pita-Romero, Rafael; Leal, Sonsoles; Sanduende, Yolanda; Rodríguez, Andrés Mauricio Quevedo; Nieto, Carlos Suárez; Vilas, Erna; Ochoa, Minerva Lazos; Cid, Milagros; Seoane-Pillado, Teresa

doi:10.1016/j.bja.2020.12.007

Cited by 178 publications

(245 citation statements)

References 16 publications

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“…[50] Austria Cohort RT-PCR confirmed cases Previously hospitalised Taboada et al. [51] Spain Cohort RT-PCR confirmed cases in intensive care Previously hospitalised Tomasoni et al. [52] Italy Cohort RT-PCR confirmed cases or CT findings Previously hospitalised Venturelli et al Italy Cohort RT-PCR or serologically confirmed and suspected cases Previously hospitalised Wang et al.…”

Section: Resultsmentioning

confidence: 99%

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Characteristics and predictors of acute and chronic post-COVID syndrome: A systematic review and meta-analysis

Iqbal¹,

Lam²,

Sounderajah³

et al. 2021

EClinicalMedicine

252

202

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Background A significant proportion of individuals experience lingering and debilitating symptoms following acute COVID-19 infection. The National Institute for Health and Care Excellence (NICE) have coined the persistent cluster of symptoms as post-COVID syndrome. This has been further sub-categorised into acute post-COVID syndrome for symptoms persisting three weeks beyond initial infection and chronic post-COVID syndrome for symptoms persisting beyond twelve weeks. The aim of this review was to detail the prevalence of clinical features and identify potential predictors for acute and chronic post-COVID syndrome. Methods A systematic literature search, with no language restrictions, was performed to identify studies detailing characteristics and outcomes related to survivorship of post-COVID syndrome. The last search was performed on 6 March 2021 and all pre-dating published articles included. A means of proportion meta-analysis was performed to quantify characteristics of acute and chronic post-COVID syndrome. Study quality was assessed with a specific risk of bias tool. PROSPERO Registration: CRD42020222855 Findings A total of 43 studies met the eligibility criteria; of which, 38 allowed for meta-analysis. Fatigue and dyspnoea were the most prevalent symptoms in acute post-COVID (0·37 and 0·35) and fatigue and sleep disturbance in chronic post-COVID syndrome (0·48 and 0·44), respectively. The available evidence is generally of poor quality, with considerable risk of bias, and are of observational design. Interpretation In conclusion, this review highlights that flaws in data capture and interpretation, noted in the uncertainty within our meta-analysis, affect the applicability of current knowledge. Policy makers and researchers must focus on understanding the impact of this condition on individuals and society with appropriate funding initiatives and global collaborative research.

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Section: Resultsmentioning

confidence: 99%

“… Taboada et al. [51] 91 65·5 (10·4) 35·2 NS NS Hypertension, hypercholesterolaemia, DM, asthma 6 months Interview collected data Tomasoni et al. [52] 105 55 (43-65) * 27 NS NS NS 46 (43-48) days * from discharge Self-reported symptom questionnaire.…”

Section: Resultsmentioning

confidence: 99%

Characteristics and predictors of acute and chronic post-COVID syndrome: A systematic review and meta-analysis

Iqbal¹,

Lam²,

Sounderajah³

et al. 2021

EClinicalMedicine

252

202

View full text Add to dashboard Cite

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“…Furthermore, numerous editorials, reviews, news articles, clinical updates, narrative interviews, and focus groups have been published to explore what it is like to live with long-term COVID-19, also trying to emphasize the putative pathophysiology, risk factors, and treatments ( 124 – 142 ). Two cohort studies on severe/critical COVID-19 patients reported persistent physiological impairment and decrease in quality of life in more than half of the patients at up to 6 months of follow up ( 77 , 100 ). Taboada et al showed that at 6 months of follow-up only 16% of patients were completely free of persistent symptoms ( 100 ).…”

Section: Resultsmentioning

confidence: 99%

“…Two cohort studies on severe/critical COVID-19 patients reported persistent physiological impairment and decrease in quality of life in more than half of the patients at up to 6 months of follow up ( 77 , 100 ). Taboada et al showed that at 6 months of follow-up only 16% of patients were completely free of persistent symptoms ( 100 ). However, in a Multistate Health Care Systems Network, Tenforde et al reported that among 270 interviews conducted on COVID-19 patients, also among persons with milder outpatient illness, 14–21 days after symptoms onset, the 35% of patients had not returned to their usual state of health ( 143 ).…”

Section: Resultsmentioning

confidence: 99%

Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data

et al. 2021

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Whilst the entire world is battling the second wave of COVID-19, a substantial proportion of patients who have suffered from the condition in the past months are reporting symptoms that last for months after recovery, i. e., long-term COVID-19 symptoms. We aimed to assess the current evidence on the long-term symptoms in COVID-19 patients. We did a systematic review on PubMed, Web of Science, EMBASE, and Google Scholar from database inception to February 15, 2021, for studies on long-term COVID-19 symptoms. We included all type of papers that reported at least one long-term COVID-19 symptom. We screened studies using a standardized data collection form and pooled data from published studies. Cohort cross-sectional, case-report, cases-series, case-control studies, and review were graded using specific quality assessment tools. Of 11,361 publications found following our initial search we assessed 218 full-text articles, of which 145 met all selection criteria. We found that 20.70% of reports on long-term COVID-19 symptoms were on abnormal lung functions, 24.13% on neurologic complaints and olfactory dysfunctions, and 55.17% on specific widespread symptoms, mainly chronic fatigue, and pain. Despite the relatively high heterogeneity of the reviewed studies, our findings highlighted that a noteworthy proportion of patients who have suffered from SARS-CoV-2 infection present a “post-COVID syndrome.” The multifaceted understanding of all aspects of the COVID-19 pandemic, including these long-term symptoms, will allow us to respond to all the global health challenges, thus paving the way to a stronger public health.

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“…According to the aim of the study, participants underwent a qualitative sleep assessment based on the Insomnia Severity Index (ISI), and the study confirmed that COVID-19-related worries and loneliness may represent the major contributing factor to clinical insomnia. All these mentioned symptoms can cause a dramatic decrease of the quality of life [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Long-COVID Syndrome? A Study on the Persistence of Neurological, Psychological and Physiological Symptoms

et al. 2021

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Background: Emerging aspects of the Covid-19 clinical presentation are its long-term effects, which are characteristic of the so-called “long COVID”. The aim of the present study was to investigate the prevalence of physical, psychological, and sleep disturbances and the quality of life in the general population during the ongoing pandemic. Methods: This study, based on an online survey, collected demographic data, information related to COVID-19, sleep disturbances, and quality of life data from 507 individuals. The level of sleep disturbances and quality of life was assessed through the Insomnia Severity Index (ISI) and the EuroQol-5D (EQ-5D), respectively. Results: In total, 507 individuals (M = 91 and F = 416 women) completed the online survey. The main symptoms associated with “long COVID” were headache, fatigue, muscle aches/myalgia, articular pains, cognitive impairment, loss of concentration, and loss of smell. Additionally, the subjects showed significant levels of insomnia (p < 0.05) and an overall reduced quality of life (p < 0.05). Conclusions: The results of the study appear in line with recent publications, but uncertainty regarding the definition and specific features of “long COVID” remains. Further studies are needed in order to better define the clinical presentation of the “long COVID” condition and related targeted treatments.

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Quality of life, functional status, and persistent symptoms after intensive care of COVID-19 patients

Cited by 178 publications

References 16 publications

Characteristics and predictors of acute and chronic post-COVID syndrome: A systematic review and meta-analysis

Characteristics and predictors of acute and chronic post-COVID syndrome: A systematic review and meta-analysis

Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data

Long-COVID Syndrome? A Study on the Persistence of Neurological, Psychological and Physiological Symptoms

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