Quality of life, hypothalamic obesity, and sexual function in adulthood two decades after primary gross-total resection for childhood craniopharyngioma

Hidalgo, Eveline Teresa; Orillac, Cordelia; Kvint, Svetlana; McQuinn, Michelle W; Dastagirzada, Yosef; Phillips, Sophie; Wisoff, Jeffrey H.

doi:10.1007/s00381-019-04161-9

Cited by 28 publications

(20 citation statements)

References 31 publications

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“…Conservative surgical therapy with adjuvant radiotherapy is supported widely by the field generally. This conservative approach contrasts with reports from a few clinical centres, in which gross total resection of tumour was associated with significantly improved quality of life 8 .…”

Section: Competing Interestscontrasting

confidence: 59%

Understanding treatment options in craniopharyngioma better

2020

Nat Rev Dis Primers

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Section: Competing Interestscontrasting

confidence: 59%

Understanding treatment options in craniopharyngioma better

2020

Nat Rev Dis Primers

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“…Surgical treatment may damage the optic chiasma and hypothalamus-pituitary axis, so surgeons need enough experience and good surgical skills to complete the operation. At present, there are many surgical methods, whether radical surgery or limited surgery, with an emphasis on protecting the hypothalamus and visual integrity and quality of life after treatment (9)(10)(11)(12). When surgeons are experienced and consider the highest recurrencefree survival (13), safe gross-total resection remains the goal (14).…”

Section: Discussionmentioning

confidence: 99%

Status Quo and Research Trends of Craniopharyngioma Research: A 10-Year Bibliometric Analyses (From 2011 to 2020)

Yang

Liu

et al. 2021

Front. Oncol.

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BackgroundCraniopharyngioma (CP) is a challenging intracranial tumor due to its special hypothalamus-pituitary location. Each patient with CP should be evaluated and treated separately. Exploring novel methods of automatized analysis of data for gaining knowledge on any medical field is an encouraging task, particularly in such an extremely challenging tumor as CP. We aim to summary the situations, investigate the research trends and evaluate research hotspots using bibliometric analysis for the CP research.MethodsWe extracted all the CP-related literatures from 2011 to 2020 from the Web of Science database. An Online analysis platform of literature metrology (Bibliometric), BICOMB, gCLUTO and CiteSpace softwares were used to do bibliometric analysis. As a supplement, we also analyzed the top 100 cited case reports with particular and certainly infrequent information to improve the analysis.ResultsAccording to our retrieval strategy, we found a total of 1262 CP-related literatures. The United States has maintained a leading position in global CP research, followed by China and Germany. Among institutions, Capital Med Univ, St Jude Childrens Res Hosp and Southern Med Univ rank in the top 3 in terms of the number of articles published. “WORLD NEUROSURGERY” is the most popular journal for CP-related research. Moreover, MULLER HL, MERCHANT TE, QI ST and others have made great achievements in the study of CP. Finally, we did biclustering analysis on keywords and identified 4 CP research hotspot clusters.ConclusionsOur research provides a comprehensive analysis of the scientific progress of CP in the past 10 years, and insight into the development of CP research field, highlight research trends over time, and help identify valuable future directions.

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“…Previous quantitative studies that have been conducted on CP patient intimacy have essentially focused on sexuality. In a study using the Medical Outcomes Study sexual functioning survey, Hildalgo et al, reported a lower proportion of sexually active individuals, compared to the general population, in 22 young adults (9 women, 13 men) with a history of CP in childhood 21 . However, global sexual functioning was not different compared to the general population, though its assessment may have been biased by the use of a standard questionnaire in a small study cohort of both women and men 22 .…”

Section: Discussionmentioning

confidence: 99%

“…Several quantitative studies have previously demonstrated a reduced quality of life in adults who underwent surgery for CP in childhood 15‐18 . Only a few studies have evaluated the intimacy of patients treated during childhood or adolescence, 19‐21 reporting decreased psychosexual function and a lower rate of sexual activity compared to the general population. In these quantitative studies, standardized questionnaires may have limited the evaluation of sexual quality of life 22 and have thus failed to allow an in‐depth exploration of patient experiences.…”

Section: Introductionmentioning

confidence: 99%

Women's perceptions of femininity after craniopharyngioma: a qualitative study

Eydoux

Castinetti

Authier

et al. 2020

Clinical Endocrinology

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Background Previous quantitative studies have shown a reduced quality of life in patients treated for craniopharyngioma (CP). However, few have assessed their sexual quality of life and other issues related to patient intimacy have not yet been addressed. Standardized questionnaires limit the approach to sexuality and the exploration of patient experiences. A qualitative study, which allows in‐depth analysis, may represent an interesting approach to explore intimacy in women with a history of CP. Objective To assess the impact of a CP history on femininity and relationships in women. Design and patients A qualitative study with semi‐structured interviews was conducted with 15 adult women treated for CP during childhood, adolescence or at childbearing age up to 40 years of age. Interviews were audio recorded, anonymized and transcribed literally. Data analysis was carried out with an inductive approach according to the grounded theory method. Results Three main themes were identified: (a) apparent changes leading to altered self‐perception that may impact on femininity and generate lower self‐esteem; (b) managing the hidden disabilities of the disease inducing a need for permanent control; and (c) building parenthood and couple relationships: coping with sexual dysfunction and infertility. Conclusions Our study highlighted alterations in self‐perception and femininity due to body change and disability resulting from CP treatment, impacting both couple and social relationships. Interviewing women who underwent CP surgery at different ages highlighted specific needs and different expectations of medical professionals which emphasize the importance of offering both global and personalized care.

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Quality of life, hypothalamic obesity, and sexual function in adulthood two decades after primary gross-total resection for childhood craniopharyngioma

Cited by 28 publications

References 31 publications

Understanding treatment options in craniopharyngioma better

Understanding treatment options in craniopharyngioma better

Status Quo and Research Trends of Craniopharyngioma Research: A 10-Year Bibliometric Analyses (From 2011 to 2020)

Women's perceptions of femininity after craniopharyngioma: a qualitative study

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