Quality of Life in Adolescents With Treated Coeliac Disease: Influence of Compliance and Age at Diagnosis

Wagner, Gudrun; Berger, Gabriele; Sinnreich, Ursula; Grylli, Vasileia; Schober, Edith; Huber, Wolf‐Dietrich; Karwautz, Andreas

doi:10.1097/mpg.0b013e31817fcb56

Cited by 122 publications

(127 citation statements)

References 23 publications

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“…Our results suggest that the HRQL found in the general population of adult celiac subjects may be lower than that observed in patients recruited in a hospital setting, giving rise to the hypothesis that periodic medical check-ups improve the quality in life for these patients by encouraging a stricter compliance with a gluten-free diet. In fact, the correct maintenance of a gluten-free diet has repeatedly been shown to be an independent factor associated with a better quality of life among celiac patients, both in children (31) and adults (19,20,22,32,33). Our study did …”

Section: Discussionsupporting

confidence: 45%

Health-related quality of life and determinant factors in celiac disease. A population-based analysis of adult patients in Spain

et al. 2016

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Background: Celiac disease (CD) has a negative impact on the health-related quality of life (HRQL) of affected patients. Although HRQL and its determinants have been examined in Spanish CD patients specifically recruited in hospital settings, these aspects of CD have not been assessed among the general Spanish population.Methods: An observational, cross-sectional study of a nonrandomized, representative sample of adult celiac patients throughout all of Spain's Autonomous Regions. Subjects were recruited through celiac patient associations. A Spanish version of the selfadministered Celiac Disease-Quality of Life (CD-QOL) questionnaire was used. Determinant factors of HRQL were assessed with the aid of multivariate analysis to control for confounding factors.Results: We analyzed the responses provided by 1,230 patients, 1,092 (89.2%) of whom were women. The overall mean value for the CD-QOL index was 56.3 ± 18.27 points. The dimension that obtained the most points was dysphoria, with 81.3 ± 19.56 points, followed by limitations with 52.3 ± 23.43 points; health problems, with 51.6 ± 26.08 points, and inadequate treatment, with 36.1 ± 21.18 points. Patient age and sex, along with time to diagnosis, and length of time on a gluten-free diet were all independent determinant factors of certain dimensions of HRQL: women aged 31 to 40 expressed poorer HRQL while time to diagnosis and length of time on a gluten-free diet were determinant factors for better HRQL scores.Conclusions: The HRQL level of adult Spanish celiac subjects is moderate, improving with the length of time patients remain on a gluten-free diet.

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Section: Discussionsupporting

confidence: 45%

Health-related quality of life and determinant factors in celiac disease. A population-based analysis of adult patients in Spain

et al. 2016

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“…30 In addition, numerous studies in pediatric and adult celiac patients have repeatedly shown that a gluten-free diet achieves not only symptom relief, but also improvements in HRQoL. [30][31][32][33] We did not evaluate the efficacy of dietary intervention in every patient who participated in our survey, and studies evaluating this issue are currently lacking. It is tempting to speculate whether identification and long-term exclusion of individual food triggers could also lead to improvements in HRQoL, as suggested in a recent study that assessed EoE with a nonspecific instrument.…”

Section: Discussionmentioning

confidence: 99%

Determinant factors of quality of life in adult patients with eosinophilic esophagitis

Lucendo

Arias-González

Molina–Infante

et al. 2017

United European Gastroenterology Journal

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Background: Eosinophilic esophagitis (EoE) affects health-related quality of life (HRQoL). Data on determinant factors and the influence of dietary interventions are scarce. Objective: The objective of this article is to evaluate factors influencing HRQoL in adult EoE patients. Methods: We conducted a multicenter observational, cross-sectional study. A validated Spanish version of the self-administered Adult Eosinophilic Esophagitis Quality of Life (EoE-QoL-A) questionnaire and specific surveys were used. Multiple linear regression was used to identify and quantify determinant factors of HRQoL. Results: Responses provided by 170 patients were assessed (73.5% male; mean age 33.5 AE 11.4 years). Overall mean score for the EoE-QoL-A index was 1.4 AE 0.8, with no differences between patients on dietary or pharmacological therapy (1.82 AE 0.8 vs. 1.62 AE 0.8; p ¼ 0.132). Disease anxiety showed the highest mean score (2.13 AE 0.9 points), followed by choking anxiety (1.97 AE 1.1); social impact (1.77 AE 1.1), and diet/eating impact (1.68 AE 0.9). Emotional impact had the lowest rating (1.15 AE 0.9), and only with a significantly worse score in patients under dietary restrictions. Recurrent food impaction, a higher educational level, dietary interventions and symptom duration were all independent determinant factors significantly impairing HRQoL. Female gender and empiric elimination diets negatively influenced on diet/eating impact. Conclusion: Recurrent food impaction, dietary interventions and symptom duration are the most important factors influencing the perception of HRQoL in adults with EoE.

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“…However, bec ause of the c ontinuing mucosal abnormalities, they remain at risk of developing the c omplic ations of CD. Indeed, adolesc ents who do not adhere to a GFD have a lower quality of life [120] . Immunohistochemical labeling has helped to define an abnormal prognostic profile of intra-epithelial lymphoc ytes in the small bowel muc osa, so-c alled "refrac tory c eliac disease, type 2 (RCD 2)" c harac terized by an aberrant c lonal IEL population with loss of IEL antigens.…”

Section: Refractory Diseasementioning

confidence: 99%

Recent advances in celiac disease

Freeman

Chopra²,

Clandinin³

et al. 2011

WJG

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Celiac disease now affects about one person in a hundred in Europe and North America. In this review, we consider a number of important and exciting recent developments, such as clinical associations, HLA-DQ2 and HLA-DQ8 predispositions, the concept of potential celiac disease, the use of new imaging/endoscopy techniques, and the development of refractory disease. This review will be of use to all internists, pediatricians and gastroenterologists.

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Quality of Life in Adolescents With Treated Coeliac Disease: Influence of Compliance and Age at Diagnosis

Cited by 122 publications

References 23 publications

Health-related quality of life and determinant factors in celiac disease. A population-based analysis of adult patients in Spain

Health-related quality of life and determinant factors in celiac disease. A population-based analysis of adult patients in Spain

Determinant factors of quality of life in adult patients with eosinophilic esophagitis

Recent advances in celiac disease

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