Quality of Life in CAPD, Transplant, and Chronic Renal Failure Patients with Diabetes

Apostolou, Theofanis; Hutchison, Alastair J.; Boulton, Andrew J.M.; Chak, Willy; Vileikyte, Loretta; Uttley, Linda; Gokal, Ram

doi:10.1080/08860220601098862

Cited by 24 publications

(37 citation statements)

References 25 publications

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“…However, most of the studies have consistently linked poor QoL with complications of DM such as peripheral neuropathy, poor visual acuity, diabetic ulcers on the foot, renal and cardiac complications, erectile dysfunction, depression, etc. (Apostolou et al, 2007;Currie et al, 2006;Clarke, Simon, Cull, & Holman, 2006;De Berardis et al, 2002Eren, Erdi, & Sahin, 2008;Goodridge et al, 2006;Pala et al, 2004;Penson et al, 2003;Valensi, Girod, Baron, Moreau-Defarges, & Guillon, 2005;Wexler et al, 2006). However, there are contradictory findings in relation to factors like metabolic control (Murtada & Nafisa, 1999;Pala et al, 2004;Wikblad, 1996), and duration of diabetes has been reported to have no influence on QoL (Wikby, 1991;Wredling & Stalammar, 1995).…”

Section: Discussionmentioning

confidence: 85%

Erectile dysfunction in diabetes mellitus contributes to poor quality of life

Grover

Bhansali

Dash

et al. 2011

International Review of Psychiatry

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Erectile dysfunction (ED) is seen in a large number of male patients with diabetes mellitus (DM). However, little is known about the impact of ED on quality of life (QoL) of DM patients. To study the QoL of men with type 2 diabetes mellitus (T2DM) and ED and compare the same for men with DM without ED 63 patients of DM with ED were compared with 30 matched patients (on sociodemographic and clinical profile, rating on depression and anxiety) of DM without ED on QoL measures using WHO-QoL-Bref. Patients with ED had poorer QoL in all domains (except the physical domain); however, the differences between the two groups were significant only for the environmental domain. ED contributes to poorer QoL in patients with diabetes mellitus.

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Section: Discussionmentioning

confidence: 85%

Erectile dysfunction in diabetes mellitus contributes to poor quality of life

Grover

Bhansali

Dash

et al. 2011

International Review of Psychiatry

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“…Health-related quality of life (HRQOL) is an important issue for both diabetes patients and dialysis patients [5-7]. HRQOL, and in particular its physical aspects, has been found to be a predictor of mortality in ESRD patients receiving dialysis [8-10].…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life and all-cause mortality in patients with diabetes on dialysis

et al. 2012

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BackgroundThis study tests the hypotheses that health-related quality of life (HRQOL) in prevalent dialysis patients with diabetes is lower than in dialysis patients without diabetes, and is at least as poor as diabetic patients with another severe complication, i.e. foot ulcers. This study also explores the mortality risk associated with diabetes in dialysis patients.MethodsHRQOL was assessed using the Short Form-36 Health Survey (SF-36), in a cross-sectional study of 301 prevalent dialysis patients (26% with diabetes), and compared with diabetic patients not on dialysis (n = 221), diabetic patients with foot ulcers (n = 127), and a sample of the general population (n = 5903). Mortality risk was assessed using a Kaplan-Meier plot and Cox proportional hazards analysis.ResultsSelf-assessed vitality, general and mental health, and physical function were significantly lower in dialysis patients with diabetes than in those without. Vitality (p = 0.011) and general health (p <0.001) was impaired in diabetic patients receiving dialysis compared to diabetic patients with foot ulcers, but other subscales did not differ. Diabetes was a significant predictor for mortality in dialysis patients, with a hazard ratio (HR) of 1.6 (95% CI 1.0-2.5) after adjustment for age, dialysis vintage and coronary artery disease. Mental aspects of HRQOL were an independent predictor of mortality in diabetic patients receiving dialysis after adjusting for age and dialysis vintage (HR 2.2, 95% CI 1.0-5.0).ConclusionsPhysical aspects of HRQOL were perceived very low in dialysis patients with diabetes, and lower than in other dialysis patients and diabetic patients without dialysis. Mental aspects predicted mortality in dialysis patients with diabetes. Increased awareness and measures to assist physical function impairment may be particularly important in diabetes patients on dialysis.

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“…To date, there have been very few large-scale studies that have investigated the determinants of HRQOL in chronic kidney disease (CKD) patients not on dialysis, or the evolution of HRQOL over time using PROs. Most studies have tended to be small in size and cross-sectional (1)(2)(3)(4)(5). Larger studies have lacked a longitudinal component (6,7), and longitudinal studies have been modest in size (8) or used tools not developed for patients with kidney disease (9).…”

mentioning

confidence: 99%

Health-related Quality of Life in CKD Patients

Mujais

Story

Brouillette

et al. 2009

Clinical Journal of the American Society of Nephrology

254

234

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Background and objectives: Very few large-scale studies have investigated the determinants of health-related quality of life (HRQOL) in chronic kidney disease (CKD) patients not on dialysis or the evolution of HRQOL over time.Design and setting: A prospective evaluation was undertaken of HRQOL in a cohort of 1186 CKD patients cared for in nephrology clinics in North America. Baseline and follow-up HRQOL were evaluated using the validated Kidney Disease Quality Of Life instrument.Results: Baseline measures of HRQOL were reduced in CKD patients in proportion to the severity grade of CKD. Physical functioning score declined progressively with more advanced stages of CKD and so did the score for role-physical. Female gender and the presence of diabetes and a history of cardiovascular co-morbidities were also associated with reduced HRQOL (physical composite score: male: 41.0 ؎ 10.2; female: 37.7 ؎ 10.8; P < 0.0001; diabetic: 37.3 ؎ 10.6; nondiabetic: 41.6 ؎ 10.2; P < 0.0001; history of congestive heart failure, yes: 35.4 ؎ 9.7; no: 40.3 ؎ 10.6; P < 0.0001; history of myocardial infarction, yes: 36.1 ؎ 10.0; no: 40.2 ؎ 10.6; P < 0.0001). Anemia and beta blocker usage were also associated with lower HRQOL scores. HRQOL measures declined over time in this population. The main correlates of change over time were age, albumin level and co-existent co-morbidities.Conclusions: These observations highlight the profound impact CKD has on HRQOL and suggest potential areas that can be targeted for therapeutic intervention.

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Quality of Life in CAPD, Transplant, and Chronic Renal Failure Patients with Diabetes

Cited by 24 publications

References 25 publications

Erectile dysfunction in diabetes mellitus contributes to poor quality of life

Erectile dysfunction in diabetes mellitus contributes to poor quality of life

Health-related quality of life and all-cause mortality in patients with diabetes on dialysis

Health-related Quality of Life in CKD Patients

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