Quality of Life in Children with Epilepsy

Hanai, Toshio

doi:10.1111/j.1528-1157.1996.tb01816.x

Cited by 59 publications

(24 citation statements)

References 5 publications

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“…When uncontrolled, TLE has serious adverse medical, social, and psychological consequences. [1][2][3][4] It is estimated that even with pharmacologic therapy, seizures will remain uncontrolled in up to one-third of all TLE patients, underscoring the urgent need for more effective treatments for TLE. 5 The etiology of TLE is poorly understood, although a large body of literature implicates both gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter, and glutamate, the primary excitatory neurotransmitter.…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABA_A-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy

Nugent

Martinez

D'Alfonso

et al. 2015

J Cereb Blood Flow Metab

115

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Glucose metabolism has been associated with magnitude of blood oxygen level-dependent (BOLD) signal and connectivity across subjects within the default mode and dorsal attention networks. Similar correlations within subjects across the entire brain remain unexplored. [18 F]-fluorodeoxyglucose positron emission tomography ([ 18 F]-FDG PET), [ 11 C]-flumazenil PET, and resting-state functional magnetic resonance imaging (fMRI) scans were acquired in eight healthy individuals and nine with temporal lobe epilepsy (TLE). Regional metabolic rate of glucose (rMRGlu) was correlated with amplitude of low frequency fluctuations (ALFFs) in the fMRI signal, global fMRI connectivity (GC), regional homogeneity (ReHo), and gamma-aminobutyric acid A-binding potential (GABA A BP ND ) across the brain. Partial correlations for ALFFs, GC, and ReHo with GABA A BP ND were calculated, controlling for rMRGlu. In healthy subjects, significant positive correlations were observed across the brain between rMRGlu and ALFF, ReHo and GABA A BP ND , and between ALFFs and GABA A BP ND , controlling for rMRGlu. Brain-wide correlations between rMRGlu and ALFFs were significantly lower in TLE patients, and correlations between rMRGlu and GC were significantly greater in TLE than healthy subjects. These results indicate that the glutamatergic and GABAergic systems are coupled across the healthy human brain, and that ALFF is related to glutamate use throughout the healthy human brain. TLE may be a disorder of altered long-range connectivity in association with glutamate function.

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Section: Introductionmentioning

confidence: 99%

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABA_A-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy

Nugent

Martinez

D'Alfonso

et al. 2015

J Cereb Blood Flow Metab

115

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“…4 Anti-epileptic drugs have the potential to impact cognitive functions. Even their modest effects can be of clinical significance and affects patient's life.…”

Section: Discussionmentioning

confidence: 99%

Effect of anti-epileptic drugs on cognitive functions: a prospective study in individuals with newly diagnosed complex partial seizure and generalized tonic clonic seizure

Rai

Yadav

Verma

et al. 2017

Int J Basic Clin Pharmacol

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INTRODUCTIONEpilepsy is a chronic condition of recurrent seizures that can also vary from brief and nearly undetectable symptoms to periods of vigorous shaking and convulsions.1 Seizures are episodic high-frequency discharge of impulses by a group of neurons in a particular area in the brain. 2 The electrical balance underlying normal neuronal activity is pathologically altered during seizures-excitation predominates over inhibition. The therapeutic goal of anti-epileptic drugs is to maximize seizure control while minimizing adverse drug effects, thus improving the patient's quality of life. Cognitive dysfunction is seen in a sizeable number of patients with epilepsy. Anti-epileptic drugs are able to improve cognition and behaviour by reducing seizure activity and modifying effects of neurotransmitter.Several relationships exist between cognitive impairment and epilepsy-related or treatment-related factors. The central cognitive side effect of the anti-epileptic drugs is one of the most important treatment-related factors. Present study was carried out in the Department of Medicine, Government Medical College, Surat with an ABSTRACT Background: Epilepsy, the third most common neurologic disorder, deteriorates cognitive functions of the patients. Approximately 1% of the world's population is suffering from epilepsy. Opinions regarding impact of anti-epileptic drugs on cognition are divided. So, this study was designed to assess the impact of anti-epileptic drugs on cognitive performance of patients with complex partial seizure and generalized tonic clonic seizure in Department of Medicine, at Government Medical College, Surat, Gujarat, India. Methods: In present study, cognitive functions were assessed in 50 patients of newly diagnosed complex partial seizure and generalized tonic clonic seizure coming to the Department of Medicine, Surat. The cognitive functions were evaluated by Addenbrooke's Cognitive Examination (ACE)-III, which assessed memory, attention, fluency, language and visuo-spatial abilities. Follow-up was done after six months of baseline. Results: Baseline and Follow-up data from 50 patients were analysed. Patient treated with anti-epileptic drugs showed significant improvement in memory, attention, language and visuo-spatial abilities whereas improvement in fluency was not significant. Paired t-test and Wilcoxon Signed Ranks Test were used to analyse the data. For statistical analysis of data SPSS 19.0 software was used. Conclusions:The available data indicate that the anti-epileptic drugs on shortterm administration do not adversely affect cognitive function in patients with newly diagnosed CPS and GTCS. Importantly, the data suggest that the effects exerted by AEDs could depend on factors linked to patient characteristics and individual susceptibility and to comment on those factors further studies are needed.

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“…It can influence not only children, but also their families and their social and educational interactions 13,25 .…”

Section: Discussionmentioning

confidence: 99%

Teachers perception about epilepsy

Fernándes

Noronha

Araújo

et al. 2007

Arq. Neuro-Psiquiatr.

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-Purpose: To identify in a town of Brazil the knowledge, attitude and perception of epilepsy in teachers of elementary schools and to compare these before and after a training exerc i s e . M e t h o d s :Teachers of nine public schools of Barão Geraldo, Campinas, Brazil completed a questionnaire. Tw o researchers had meetings with teachers, presenting the Global Campaign "Epilepsy out of the shadows", when the questionnaire was first completed by all attendees. Twenty teachers of these schools were motivated to attend a training course entitled "Epilepsy and Health" as part of their continuous education programme. Two years later the same questionnaire was again completed (post-test) by these 20 teachers. Results: 100 teachers originally completed the questionnaire (97 women, mean age 42 years, 64 marr i e d ) . F o rt y -t h ree percent of teachers said that they had enough knowledge re g a rding epilepsy and 20% said that they had poor knowledge about the condition. Regarding the IQ of children with epilepsy, 45% of teachers believed that they had average IQ, 18% above average, six percent under average and 29% did not know. Teachers believed that children with epilepsy have a higher possibility of acquiring mental disease in the future (51%); that epilepsy is a disease (68%); that epilepsy is contagious (1%); epilepsy is tre a table (90%). After the course, the teachers' beliefs seem to have impro v e d . Discussion: This work with e l e m e n t a ry school teachers identified difficulties related to epilepsy which, if addressed, may help promote better quality of life of people with epilepsy in the community and help to decrease stigma attached to the condition. Better informed teachers are likely to have a more positive attitude and this will be passed to others. Educational campaigns about epilepsy amongst teachers should be encouraged as this may improve the management of epilepsy, by helping to develop a well informed and tolerant community.KEY WORDS: epilepsy, stigma, school, teachers.Percepção de professores sobre epilepsia RESUMO -Objetivo: Identificar atitudes e percepção dos pro f e s s o res do ensino fundamental a respeito da epilepsia, antes e depois de um curso específico sobre o tema. Método: P a rticiparam da pesquisa pro f e ssores de nove escolas da rede pública do ensino fundamental de Barão Geraldo, distrito de Campinas, SP. Dois pesquisadores reuniram-se com os pro f e s s o res e apresentaram a Campanha Global "Epilepsia fora das sombras", momento também em que os questionários foram aplicados. Vinte pro f e s s o res ficaram motivados para fazer o curso de extensão "Temas transversais: epilepsia e saúde". Após este curso, os questionários foram re -a p l i c a d o s . Resultados: Foram aplicados 100 questionários em pro f e s s o res das nove escolas, sendo que: noventa e sete professores eram do sexo feminino, idade média de 42 (D.P. 22 a 63) e 64 estavam casados. Quarenta e três pro f e s s o res declararam possuir conhecimento sobre epilepsia abaixo da média e 20, disseram ...

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Quality of Life in Children with Epilepsy

Cited by 59 publications

References 5 publications

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABA_A-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABA_A-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy

Effect of anti-epileptic drugs on cognitive functions: a prospective study in individuals with newly diagnosed complex partial seizure and generalized tonic clonic seizure

Teachers perception about epilepsy

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Quality of Life in Children with Epilepsy

Cited by 59 publications

References 5 publications

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABAA-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABAA-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy

Effect of anti-epileptic drugs on cognitive functions: a prospective study in individuals with newly diagnosed complex partial seizure and generalized tonic clonic seizure

Teachers perception about epilepsy

Contact Info

Product

Resources

About

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABA_A-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy

The Relationship between Glucose Metabolism, Resting-State fMRI BOLD Signal, and GABA_A-Binding Potential: A Preliminary Study in Healthy Subjects and Those with Temporal Lobe Epilepsy