Quality of life in children with retinoblastoma after enucleation in China

Zhang, Lili; Gao, Tao; Shen, Yi

doi:10.1002/pbc.27024

Cited by 23 publications

(43 citation statements)

References 22 publications

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“…Moreover, our results indicate that survivors of RB with monocular vision, who did not have motor deficits, also tended to have lower physical and social QOL compared with the typically developing children. These results are congruent with several previous studies showing that survivors of childhood RB have a lower QOL 25,26.…”

supporting

confidence: 93%

The impact of monocular vision on motor function and quality of life in survivors of retinoblastoma

Weintraub

Reshef

Pe’er

et al. 2019

Pediatric Blood & Cancer

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Background Monocular vision has been found to have a negative effect on children's motion processing and motor functions. Yet, knowledge of motor function of survivors of retinoblastoma (RB) with monocular vision (due to enucleation, for example) is limited. This study examined motor function and its relationship to visual‐related and health‐related quality of life (HRQOL) in survivors of RB with monocular vision. Procedure Parents of 27 survivors of RB, who underwent an enucleation of one eye resulting in monocular vision, and of 21 typically developing children between the ages of 6 and 12, were administered questionnaires relating to their children's motor function (DCDQ), as well as vision‐related function (CVFQ) and HRQOL (PedsQL). Results Of the 27 survivors of RB, 7 (25.6%) were found to have difficulties in motor functions, compared with 1 (4.8%) child in the control group. The difficulties were faced mainly in daily function requiring control during movement, including jumping, running, and ball playing. Additionally, significant correlations were found between motor functions and children's QOL. Finally, survivors of RB with monocular vision were found to have lower QOL, specifically physical‐ and school‐related QOL. Conclusion Survivors of RB who have monocular vision have a higher rate of decreased motor function and lower QOL. These results point to a need for ongoing assessment of survivors of RB to allow timely detection of motor deficits and to institute appropriate therapeutic interventions.

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supporting

confidence: 93%

The impact of monocular vision on motor function and quality of life in survivors of retinoblastoma

Weintraub

Reshef

Pe’er

et al. 2019

Pediatric Blood & Cancer

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“…Regarding children with RB, most of the previous studies conducted in developed countries have investigated QoL and also found that children with RB experience a relatively good QoL [17,18]. However, the studies in India and China suggest that the QoL of children with RB is significantly lower than that of normal children [19,20]. A lower age at diagnosis seemed to be the key factor that determined a higher QoL.…”

Section: Discussionmentioning

confidence: 96%

Quality of Life (QoL) and Psychosocial Outcomes in Adult Survivors of Unilateral Retinoblastoma (RB) in China

Feng

Zhou

Jia

et al. 2020

Journal of Ophthalmology

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Purpose. To assess the quality of life (QoL) and the long-term psychosocial outcomes in adult survivors of unilateral retinoblastoma (RB). Methods. This is a cross-sectional study. Enrolment was offered to all adult survivors of unilateral RB who were treated by enucleation and were followed up in the Ninth People’s Hospital of Shanghai Jiao Tong University School of Medicine; noncancer healthy adults served as a control group. All participants completed a series of questionnaires consisting of two aspects, QoL and psychosocial status. The psychosocial outcomes included anxiety, depression, fear of cancer, and satisfaction with facial appearance. Results. A total of 66 RB survivors (43.0% male) and 66 healthy adults (33.3% male) were aged 27.94 ± 7.63 and 29.18 ± 8.37 at the time of the study, respectively. Adult RB survivors did not have significantly higher rates of depression and anxiety compared with the control group, and they experienced a relatively good QoL. RB survivors were more likely to worry about their facial appearance (median, 1.59 [inter-quartile range, IQR, 1.27 to 2.16] v median, 0.36 [IQR, 0.09 to 1.18]; p<0.001). Radiotherapy was not the factor affecting satisfaction with facial appearance (β, −0.27 [confidence interval, CI, −0.69 to 0.16]; p=0.214). Females were more likely to be influenced by the disease (mean, 29.59 ± 8.89 v mean, 24.37 ± 6.92; p=0.031) and worry about their appearance (mean, 1.88 ± 0.84 v mean, 1.46 ± 0.77; p=0.041). Conclusions. Unilateral RB survivors are a fairly healthy and resilient group. Most unilateral RB survivors experience a relatively good QoL, and they do not have poorer psychosocial functioning compared with a noncancer sample. Females may need more specific psychosocial care.

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“…The literature findings on the impact of retinoblastoma on HRQOL are varied. Five studies identified worse HRQOL in retinoblastoma survivors than the general population (n = 2; Alessi et al, 2007;Sheppard et al, 2005) or controls (n = 3; Batra et al, 2015;Batra et al, 2016;Zhang et al, 2018). An additional five studies reported overall HRQOL similar to normative samples HRQOL was not substantially different than controls.…”

Section: Health-related Quality Of Lifementioning

confidence: 90%

A Review of Literature on Health-Related Quality of Life of Retinoblastoma Survivors

Belson

Eastwood

Brecht

et al. 2019

J Pediatr Oncol Nurs

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Background: Retinoblastoma is a malignant tumor of the eye that typically presents in early childhood and occurs in approximately 1 in 20,000 births. While active treatment of the tumor is typically completed in childhood, survivors often suffer from long-term effects from treatment including visual impairment, facial deformities, and fear of recurrence or secondary cancer. However, little is known how these long-term effects affect their health-related quality of life (HRQOL). Purpose: To review the literature on HRQOL in retinoblastoma survivors. Method: We searched three electronic databases from January 2005 to December 2018 for original research articles reporting on HRQOL or individual domains such as function, cognition, and psychosocial outcomes in retinoblastoma survivors. Results: A total of 59 articles were reviewed and 15 were identified as eligible. Five of the studies reported worse HRQOL in retinoblastoma survivors than controls or general population norms. Parent-proxy ratings were worse than survivors’ self-reports. Conclusion: Our findings confirm the need for further HRQOL research to assess the factors influencing long-term outcomes associated with treatment in adolescent and young adult retinoblastoma survivors. By identifying any potential deficits in specific domains of HRQOL, early interventions might be developed to improve HRQOL in retinoblastoma survivors.

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Quality of life in children with retinoblastoma after enucleation in China

Cited by 23 publications

References 22 publications

The impact of monocular vision on motor function and quality of life in survivors of retinoblastoma

The impact of monocular vision on motor function and quality of life in survivors of retinoblastoma

Quality of Life (QoL) and Psychosocial Outcomes in Adult Survivors of Unilateral Retinoblastoma (RB) in China

A Review of Literature on Health-Related Quality of Life of Retinoblastoma Survivors

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