Quality of life in chronic kidney disease: effects of treatment modality, depression, malnutrition and inflammation

Abstract

In the present study, our aim is to investigate the effects of the treatment modality, depression, malnutrition and inflammation on quality of life (QoL) in chronic kidney disease (CKD). Twenty-six patients with CKD on conservative management, 68 patients on haemodialysis (HD), 47 patients on continuous ambulatory peritoneal dialysis (CAPD) and 66 healthy controls were enrolled in the study. QoL was measured by means of the Short Form-36 (SF-36) and subscale scores were calculated. All patients were evaluated for the presence of depression using the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I Disorders - Clinician Version. The severity of depression was evaluated by means of the Beck Depression Inventory (BDI). Serum C-reactive protein (CRP), ferritin, albumin, haemoglobin and haematocrit (Hct) levels were measured. All the SF-36 subscale scores were lower in the patient groups compared with control group. The SF-36 scores were higher and BDI scores were lower in the CAPD group than CKD and HD groups. In patients with depression, all SF-36 subscale scores were lower than that of the patients without depression. There was a significant negative correlation between all the SF-36 subscale scores and the BDI scores. There was a significant positive correlation between the SF-36 physical and total summary scores and the Hct value and serum albumin levels, but an inverse correlation between the SF-36 physical, mental and total summary scores and the serum CRP level in the HD patients. The authors suggest that the treatment modality, depression, malnutrition and inflammation have an important role on QoL in CKD.

Comparison of Health-Related Quality of Life of Patients on Hemodialysis and Continuous Ambulatory Peritoneal Dialysis

“…19 In so me ot her stu di es QOL sco res we re higher in the CAPD pa ti ents. [20][21][22][23][24] The study of Ka lender et al whe re SF-36 was used to eva lu a te QOL of chro nic kid ney di se a se pa ti ents re por ted that the SF-36 sco res we re hig her in the CAPD gro up than HD gro up. 20 Shrest ha et al sta ted that pa ti ents on CAPD ha d bet ter qu a lity of li fe than pa ti ents on HD es pe ci ally in terms of men tal he alth.…”

“…[20][21][22][23][24] The study of Ka lender et al whe re SF-36 was used to eva lu a te QOL of chro nic kid ney di se a se pa ti ents re por ted that the SF-36 sco res we re hig her in the CAPD gro up than HD gro up. 20 Shrest ha et al sta ted that pa ti ents on CAPD ha d bet ter qu a lity of li fe than pa ti ents on HD es pe ci ally in terms of men tal he alth. 21 Gi ni e riCoc co sis et al al so sta ted in the ir study that pa tients on HD tre at ment, par ti cu larly tho se with many ye ars of tre at ment, we re ex pe ri en cing a more com pro mi sed QOL in com pa ri son to CAPD/PD pa ti ents.…”

“…Ka len der et al re por ted that the re was a sig ni fi cant po si ti ve cor re la ti on bet we en the SF-36 physi cal sco res and both the he ma toc rit va lu e and se rum al bu min le vels. 20 Shrest ha et al sta ted that va ri ab les li ke he mog lo bin, he ma toc rit and ade quacy of di aly sis ha d a po si ti ve cor re la ti on with all the fo ur do ma ins of the KDQOL sca le i.e. op ti mi zing the se va ri ab les im pro ves the ove rall qu a lity of li fe.…”

Structural Equation Modeling on Quality of Life in Pre-dialysis Patients with Chronic Kidney Disease

“…또한 우울 (Kalender, Ozdemir, Dervisoglu, & Ozdemir, 2007), 불안 (Tong et al, 2009), 피로 (Rodrigue et al, 2011), 수면 장애 (Cohen, Patel, Khetpal, Peterson, & Kimmel, 2007)와 같은 생행동적 요인이 삶의 질에 부정적인 영향 을 미치는 것으로 보고되었으며 (Wood, Klebba, & Miller, 2000), 사회 적 지지 또한 만성 신부전 환자의 삶의 질에 직접적 (Cohen et al) 또 는 간접적으로 영향을 주는 것으로 보고되었다 (Hoth, Christensen, Ehlers, Raichle, & Lawto, 2007). 영양학적, 신체적 요인은 수면장애 (Cohen et al), 우울 (Kohatsu, 2005) …”

Illness Perception as a Predictor of Health-Related Quality of Life in Patients with End Stage Renal Disease: Comparison between Haemodialysis and Continuous Ambulatory Peritoneal Dialysis Patients

“…Obviously other factors must have contributed to these findings. Kalander et al (2007) reported that the different of QoL based on dialysis modality could be explained by differences in socio-demographic characteristic, patients' clinical features or the methods used to measure the QoL. Hence none of the findings reported to date could be generalised to ESRD patients in other societies or geographic locations.…”