Quality of Life in COVID-19 Outpatients: A Long-Term Follow-Up Study

Tarazona, Vincent; Kirouchena, David; Clerc, Pascal; Pinsard-Laventure, Florence; Bourrion, Bastien

doi:10.3390/jcm11216478

Cited by 23 publications

(23 citation statements)

References 25 publications

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“…As displayed in Table 1, the current systematic review comprised 20 studies representing a variety of countries. Each of the subsequent countries had one research conducted: Sweden [35], Switzerland [27], Germany[16], Italy [17], Slovakia [23], Norwegian [29], France [32], Netherlands [33], Denmark [25], and Spain [28]. Two studies were done in Norway [20,30], while another 2 studies were reported in Israeli [19,24], four studies were performed in the UK [21,22,26,31] and one study in the USA [18].…”

Section: Study Selection and Characteristics Of Included Studiesmentioning

confidence: 99%

“…However, other studies conducted comprehensive 7-month, 9month, and 10-month follow-up periods, [16, 19,23]. Effectively, more studies focused on the long-term progression of the condition [20,28,32]. Some studies implemented a exible approach toward follow-up and had a follow-up period of 6-12 months, 3-8 months, and 3-5 months [18, 24,30].…”

Section: Follow-up Since Covid-19 Onsetmentioning

confidence: 99%

“…Fifteen of the twenty studies have a score of more than six out of 10 and are considered of fair quality. While ve studies had a score of ve or less and may have a high risk of bias either because of a small sample size, different rates of non-response, subjective assessment of outcomes, or non-adjustment for confounding factors [16,17,19,27,32].…”

Section: Quality Assessment Of the Included Studiesmentioning

confidence: 99%

See 2 more Smart Citations

The burden of persistent symptoms after COVID-19 (long COVID): A Meta-analysis of controlled studies in children and adults

Azzam

Khaled

Refaey

et al. 2023

Preprint

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Background Previous meta-analyses estimating the prevalence of the post-COVID-19 condition (PCC) were confounded by the lack of negative control groups. This may result in an overestimation of the prevalence of those experiencing PCC, as these symptoms are non-specific and common in the general population. In this study, we aimed to compare the burden of persistent symptoms among COVID-19 survivors relative to COVID-19-negative controls. Methods A systematic literature search was conducted using the following databases (MEDLINE, Web of Science, and Scopus) until July 2023 for comparative studies that examined the prevalence of persistent symptoms in COVID-19 survivors. Given that many of the symptoms among COVID-19 survivors overlap with post-hospitalization syndrome and post-intensive care syndrome, we included studies that compare the prevalence of persistent symptoms in hospitalized COVID-19 patients relative to non-COVID-19 hospitalized patients and in non-hospitalized COVID-19 patients relative to healthy controls that reported outcomes after at least three months since infection. The results of the meta-analysis were reported as odds ratios with a 95% confidence interval based on the random effects model. Results Twenty articles were included in this study. Our analysis of symptomatology in non-hospitalized COVID-19 patients compared to negative controls revealed that the majority of symptoms examined were not related to COVID-19 infection and appeared equally prevalent in both cohorts. However, non-COVID-19 hospitalized patients had higher odds of occurrence of certain symptoms like anosmia, ageusia, fatigue, dyspnea, and brain fog (P < 0.05). Particularly, anosmia and ageusia showed substantially elevated odds relative to the negative control group at 11.27 and 9.76, respectively, P < 0.05. In contrast, analysis of hospitalized COVID-19 patients compared to those hospitalized for other indications did not demonstrate significantly higher odds for the tested symptoms. Conclusions The persistent symptoms in COVID-19 survivors may result from hospitalization for causes unrelated to COVID-19 and are commonly reported among the general population. Although certain symptoms exhibited higher odds in non-hospitalized COVID-19 patients relative to controls, these symptoms are common post-viral illnesses. Therefore, the persistent symptoms after COVID-19 may not be unique to SARS-CoV-2. Future studies including well-matched control groups when investigating persistent symptoms in COVID-19 survivors are warranted to draw a firm conclusion.

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Section: Study Selection and Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Follow-up Since Covid-19 Onsetmentioning

confidence: 99%

Section: Quality Assessment Of the Included Studiesmentioning

confidence: 99%

See 1 more Smart Citation

The burden of persistent symptoms after COVID-19 (long COVID): A Meta-analysis of controlled studies in children and adults

Azzam

Khaled

Refaey

et al. 2023

Preprint

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“…The frequency and burden of long COVID increase with the severity of acute disease 11 , but it also occurs in patients with mild symptoms who do not require hospitalization 12 . Long COVID has been shown to negatively impact quality of life 13 , 14 and can persist for a long time after infection 15 . Investigations into the long-term effects of COVID-19 beyond 2 years are limited.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of long COVID and the impact of COVID-19 vaccination on long COVID 2 years following COVID-19 infection: prospective cohort study

Kim,

Bae,

Chang

et al. 2024

Sci Rep

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This prospective cohort study aimed to identify characteristics of long COVID and any potential mitigating effects of COVID-19 vaccinations in patients 24 months following COVID-19 infection. Adult patients diagnosed with COVID-19 between February 17, 2020, and March 24, 2020, were scheduled to visit the study hospital four times (6, 12, 18, and 24 months after infection) to assess their symptoms, quality of life, and mental health. Among the 235 patients, 121 (51.5%) completed the study visits. Of these, 59.5% were female, with a median age of 52 years. Mild to moderate disease severity were identified in 101 (83.4%) patients. A total of 75 participants (62.0%) were still experiencing long COVID symptoms 24 months after acute infection. Fatigue, amnesia, difficulty concentrating, and insomnia were the most common symptoms. The frequency of neuropsychiatric symptoms did not differ based on vaccination status or the number of doses received. Quality of life improved over time for the participants, but 32.2% of respondents still reported anxiety/depression at the end of the study. Overall, our cohort demonstrates that long COVID can persist up to 24 months after COVID-19 infection, affecting mental health and quality of life.

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“…Even in non-hospitalized workers, COVID has affected the health of the victims, and its post-sequelae has been less studied. Persistence of symptoms post-COVID, especially chest symptoms like early fatigue with breathlessness, has been documented very well [ 2 , 3 ]. A study done by Lee et al in China has shown that in re-confirmed cases of COVID-19, physical symptoms after quarantine persisted along with feelings of depression and psychological stress.…”

Section: Introductionmentioning

confidence: 99%

Post-COVID Quality of Life and Sleep Among Younger Healthcare Workers of Designated COVID Care Centers: A Cross-Sectional Study

TS¹,

KK²,

Bhavanam³

et al. 2023

Cureus

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Introduction Frontline healthcare workers (FLHCWs) have been persuaded to work this coronavirus disease (COVID) pandemic way in and out but the pandemic has not subsided. The persistence of symptoms after COVID infection, especially chest symptoms like early fatigue with breathlessness, has been documented very well. However, FLHCWs have repeatedly caught the COVID infection and have been working in traumatic and helpless situations since the pandemic started. Post-COVID infection, quality of life (QOL) and sleep are greatly affected, regardless of the time elapsed since discharge or recovery. The continuous assessment of COVID-infected persons for post-COVID sequelae is an important and effective step to reduce complications. Materials and methods This was a cross-sectional study conducted for a period of one year at R.L. Jalappa Hospital and Research Center, Kolar, and SNR District Hospital, Kolar, which were designated COVID care centers. FLHCWs working in these centers who had contracted COVID infection at least once, who were more than 18 years and less than 30 years, and who had experience of less than five years irrespective of their vaccination status were included in the study. FLHCWs with COVID-related health illnesses, which needed ICU admission and prolonged hospital admission, were excluded. To assess QOL, the WHO Quality of Life Brief Version (WHOQOL-BREF) questionnaire was used. To assess sleepiness, the Epworth daytime sleepiness scale was used. The study was started after the institutional ethical committee's clearance was obtained. Results A total of 201 healthcare workers (HCWs) completed the survey. Of the participants, 119 (59.2%) were male, 107 (53.2%) were junior residents, 134 (66.7%) were unmarried, and 171 (85.1%) said they followed regular shifts. Male HCWs had higher scores in the psychological, social relationship, and environmental domains of QoL. Consultants had higher scores in all domains of QoL. Married HCWs had higher scores in the physical, psychological, and social relationship domains of QoL. Out of 201 FLHCWs, 67 (33.3%) had moderate excessive daytime sleep, and 25 (12.4%) had severe excessive daytime sleep. Few factors like gender, occupation, duration of work in the hospital, and regular shifts were statistically significant factors associated with daytime sleepiness. Conclusion The present study has shown that even after the COVID vaccination doses received by the HCWs, sleep and Qol have still been impaired among infected younger healthcare staff. Acceptable and righteous efforts must be made by the institutions for proper policymaking to manage such infectious outbreaks in the future.

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Quality of Life in COVID-19 Outpatients: A Long-Term Follow-Up Study

Cited by 23 publications

References 25 publications

The burden of persistent symptoms after COVID-19 (long COVID): A Meta-analysis of controlled studies in children and adults

The burden of persistent symptoms after COVID-19 (long COVID): A Meta-analysis of controlled studies in children and adults

Characteristics of long COVID and the impact of COVID-19 vaccination on long COVID 2 years following COVID-19 infection: prospective cohort study

Post-COVID Quality of Life and Sleep Among Younger Healthcare Workers of Designated COVID Care Centers: A Cross-Sectional Study

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