Quality of life in early-onset Alzheimer’s disease due to a PSEN1-E280A mutation

Vásquez, Daniel; Castrillon, Melissa Sierra; Vega, Manuela Gomez; Henck, Clara Gomez; Aguillón, David; García-Cifuentes, Elkin; Jaramillo‐Jimenez, Alberto; Velez, Juan Esteban; Madrigal, Lucía; Lopera, Francisco

doi:10.1007/s10072-021-05136-y

Cited by 3 publications

(2 citation statements)

References 47 publications

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“…A greater increase in the prevalence of dementias is expected in Latin America than in high-income countries, between 7.1% and 11.5% for those over 60 years of age; compared with a lower, stable, or reduced prevalence in the United States and Europe. Different non-modifiable and modifiable factors have been identified, such as a marked genetic heterogeneity, with specific populations identified in Colombia, with the identification of the "paisa gene" (Vasquez et al, 2021), in Mexico with the identification of the "Jalisco gene" (Dumois-Petersen et al, 2020);Dominican Republic, Puerto Rico, and in Cuba (Llibre-Guerra et al, 2021). The cost of AD is a greater burdensome in Latin America than it is for the rest of the planet (Custodio, Wheelock, Thumala, & Slachevsky, 2017) due to a more challenging intervention of risk factors, social determinants of health, and the effect of the SARS-CoV2 pandemic (Parra et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

What diseases affect elderly Mexican population? Clinical and socialdemographic characteristics of patients of the psychogeriatric clinic of the National Institute of Psychiatry

2023

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Introduction. The demographic and epidemiological transition, as well as the aging population has changed how older adults are treated in our healthcare system. Objective. To establish the sociodemographic and clinical characteristics of the patients from the Psychogeriatric Clinic (PC) of the Ramón de la Fuente Muñiz National Institute of Psychiatry (INPRFM) seen between January 1, 2011, and December 31, 2020. Method. Descriptive, observational, cross-sectional, retrospective study. A database was created with the information from digital clinical records. No additional scales were used. Statistical analysis performed in SPSS 20.0. Results. 2056 records were found, 1247 met the inclusion criteria. The mean age was 74.28 years, women 73.46% (n = 916), primary school 46.62% (n = 427), married 35.70% (n = 327), urban area 93.99% (n = 1172), home-based 78.28% (n = 717), low socioeconomic level 59.99% (n = 522). The most common psychiatric pathology was depressive disorders 62.07% (n = 774) and neurocognitive disorders 37.52% (n = 468) due to Alzheimer’s disease 17.08% (n = 213), with Mini-Mental State Examination of 18.88 points (± 6.68). They had comorbidities such as arterial hypertension 52.85% (n = 659), diabetes mellitus 23.34% (n = 291) and had a geriatric syndrome in 64.42% (n = 218). Discussion and conclusion. Aging in Mexico affects the female population the most. The analysis report from the prevalence for psychogeriatric pathologies of the PC it’s for of its kind. The main goal is promoting research on dementias and highlighting the magnitude of the problem for Latin American governments. The results are not intended to be extrapolated to the general population.

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Section: Discussionmentioning

confidence: 99%

What diseases affect elderly Mexican population? Clinical and socialdemographic characteristics of patients of the psychogeriatric clinic of the National Institute of Psychiatry

2023

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“…In FTD, apathy, disinhibition and psychosis were strongly associated with caregiver burden [65 ▪ ] with more frequently problem-focused and positive emotion coping strategies employed by their caregivers [66]. Increasing dependence of the individual with dementia may also be associated with caregiver quality of life [67].…”

Section: Psychosocialmentioning

confidence: 99%

Recent research advances in young-onset dementia

Loi

Pijnenburg

Velakoulis

2022

Current Opinion in Psychiatry

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Purpose of reviewYoung-onset dementia (YOD) refers to a dementia for which symptom onset occurs below the age of 65. This review summarizes the recent literature in this area, focusing on updates in epidemiology, diagnosis and service provision. Recent findingsIn the last year, internationally, the prevalence of YOD was reported as 119 per 100 000, but this may vary according to population types. Although the commonest causes of YOD are Alzheimer's disease (AD) and frontotemporal dementia (FTD), there is increasing recognition that YOD is diagnostically and phenotypically broader than AD and FTD. YOD may be due to many other diseases (e.g. Huntington's disease, vascular dementia) whereas accumulation of the same protein (e.g. amyloid protein) may lead to different phenotypes of Alzheimer's disease (such as posterior cortical atrophy and behavioural-variant/ frontal-variant AD). This heterogeneity of phenotypic presentation is also seen in YOD due to known genetic mutations. Biomarkers such as plasma and cerebrospinal fluid proteins, neuroimaging and genetics have shown promise in the early identification of YOD as well as providing further understanding behind the overlap between psychiatric and neurodegenerative conditions occurring in younger people. The management of YOD needs to consider age-specific issues for younger people with dementia and their family networks together with better integration with other health services such as aged, disability and improved access to services and financial assistance.

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Creativity During COVID-19: Evaluating an Online TimeSlips Storytelling Program for People Living With Dementia During Quarantine in Colombia

et al. 2023

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Background and Objectives Since its first implementation in 1998, evidence has been presented of the positive impact of the TimeSlips storytelling method for people with dementia in long-term care (LTC) settings. This paper extends this evidence in important new directions: it is the longest TimeSlips study to date and the first to evaluate the feasibility of online delivery of the method (in response to COVID-19 quarantine) and the impact of this on the personhood, quality of life and psychological well-being of Spanish-speaking participants in non-LTC settings in the Global South. Research Design and Methods Trained facilitators provided weekly, one-hour TimeSlips sessions via Zoom over 32 consecutive weeks to eight participants with dementia. Semi-structured interviews of participants and care partners were conducted within one week of the final intervention. Thematic analysis evaluated the resultant qualitative data. Results This online implementation of the TimeSlips creative expression (CE) method reinforced key facets of participants’ personhood (self-expression and self-perception, which led in turn to increased care partner appreciation), had a positive impact on key domains of quality of life (mood, energy levels and cognitive function) and stimulated a key aspect of psychological well-being (the formation and maintenance of social ties). Discussion and Implications The online delivery of the TimeSlips method to participants who remain in their own homes is feasible and effective. Future research should compare the benefits of online versus face-to-face delivery of this CE method.

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Quality of life in early-onset Alzheimer’s disease due to a PSEN1-E280A mutation

Cited by 3 publications

References 47 publications

What diseases affect elderly Mexican population? Clinical and socialdemographic characteristics of patients of the psychogeriatric clinic of the National Institute of Psychiatry

What diseases affect elderly Mexican population? Clinical and socialdemographic characteristics of patients of the psychogeriatric clinic of the National Institute of Psychiatry

Recent research advances in young-onset dementia

Creativity During COVID-19: Evaluating an Online TimeSlips Storytelling Program for People Living With Dementia During Quarantine in Colombia

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