“…Recent systematic reviews identified the Child Oral Health Impact Profile (COHIP) as one of the most valid and reliable instruments among those specifically designed for children and teenagers with orofacial anomalies to measure their own OHRQoL [ 21 , 22 ]. Numerous studies have investigated the influence of CLP on OHRQoL using this survey instrument, and they have reported contradictory findings, as some described low levels of QoL, while others did not show any significant impact [ 23 , 24 , 25 , 26 , 27 ]. Differences in age, ethnicity, sample size, treatment protocols, and study designs may partly account for this discrepancy.…”