Quality of life in head and neck cancer patients: Impact of HPV and primary treatment modality

Maxwell, Jessica H.; Mehta, Vikas; Wang, Hong; Cunningham, D.; Duvvuri, Umamaheswar; Kim, Seungwon; Johnson, Jonas T.; Ferris, Robert L.

doi:10.1002/lary.24508

Cited by 53 publications

(54 citation statements)

References 23 publications

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“…Additionally, our study confirms the previous findings that p16 positive cases have better quality of life over their counterparts [21], often attributed to improved survival, younger age and lack of smoking, although other studies have found no difference [22].…”

Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 91%

Preradiotherapy dental extractions and health-related quality of life

Beech

Porceddu

Batstone

2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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word count: 188 Manuscript word count: 3587 Number of references: 25 Number of tables: 7 AbstractBackground: Health-related quality of life (HRQoL) is a valuable outcome measurement of treatment, particularly in patients undergoing therapy for malignancy. Due to the effects of both disease and treatment, it is important for clinicians to understand the holistic experience of the patient, not just the direct physical effect on morbidity and mortality. Oropharyngeal cancers are often treated with radiation to the head and neck, which presents a number of issues that will affect quality of life, including difficult to manage sequelae such as osteoradionecrosis. Dental extractions performed under any circumstances have an impact on quality of life, and those performed pre and post-radiotherapy are no exception. Aim: The aim of this study was to investigate the connection between preradiotherapy dental extractions and self-reported health related quality of life. Methods: Retrospective data on patients treated with radiotherapy for oropharyngeal cancer were pooled with a cross-sectional survey. Results: greater than 8 pre-radiotherapy dental extractions, p16 negative status, female gender and positive smoking status were associated with statistically significant reduced quality of life. Conclusion: pre-radiotherapy dental extractions do not result in improved quality of life, and may in fact worsen it.

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Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 91%

Preradiotherapy dental extractions and health-related quality of life

Beech

Porceddu

Batstone

2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…Maxwell et al [33] showed that p16-positive head and neck squamous cell carcinoma patients have better QoL scores at baseline irrespective of the treatment modality compared with the p16-negative counterparts. The HPV-positive patients had worse salivary function in the early stage of recovery than HPV-negative counterparts.…”

Section: Discussionmentioning

confidence: 98%

Trends in the 15D health-related quality of life over the first year following diagnosis of head and neck cancer

Aro

Bäck

Loimu

et al. 2015

Eur Arch Otorhinolaryngol

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Management of head and neck cancer influences both physical and mental wellbeing. Measuring the health-related quality of life (HRQoL) is important, as various treatment modalities are associated with significant morbidity and mortality. In this prospective cohort study, we tested the feasibility of the generic 15D HRQoL instrument in 214 head and neck cancer patients managed with surgery, definitive (chemo)radiotherapy, or with combined modality treatment. HRQoL was assessed at baseline and three times after treatment onset during 1 year, and compared with that of general population standardized for age and sex. At baseline, the patients' mean 15D score was significantly worse compared with general population. Overall HRQoL was at lowest at 3 months after treatment onset, it gradually improved towards 12 months but never reached baseline levels. The dimensions "vitality", "distress", "depression" and "sexual activity" showed marked deterioration at 3 months after the treatment onset, but improved gradually during 12 months. The 15D instrument seems useful for evaluation of HRQoL of head and neck cancer patients. Dimensions reflecting mental wellbeing improved gradually after 3 months, but they seldom reached baseline levels. The support for patients at the time of diagnosis, during treatment, and recovery is emphasized.

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“…On multivariate analysis controlling for tumor site, this association did not remain significant. Lately, Maxwell et al [70] determined the posttreatment QOL (using same questionnaire as our study) in the head and neck cancer (including OCSCC and OPC) patients, classifying by HPV status and primary treatment modality (surgical vs nonsurgical) and showed that HPV patients had better QOL scores in speech (P = 0.0009), chewing (P = 0.0004), and swallowing (P = 0.021) after 1 year posttreatment compared to HPV-negative patients. Primary treatment modality did not affect overall QOL or any of the QOL categories in HPV-positive patients.…”

Section: Discussionmentioning

confidence: 99%

Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment—a Pilot Study from Northern India

Singh

Kushwaha

Anand

et al. 2016

Indian J Surg Oncol

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Human papilloma virus (HPV)-associated head and neck cancer (HNC) has generated significant amount of research interest in recent times with focus shifted to oral cavity squamous cell cancer (OCSCC) after oropharyngeal cancer. Due to high incidence of OCSCC and anecdotal reports on association of HPV infection from northern region of India, this study was conceived to investigate HPV infection and establish its association with lifestyle habits such as tobacco, alcohol consumption, oro-genital sex, number of sexual contacts, and change in quality of life posttreatment. A total of 43 primary OCSCC biopsy specimens were collected. These samples were analyzed for HPV DNA genotyping which was done by using 13 high-risk HPV real-time PCR kits. Quality of life was assessed using University of Washington questionnaire for HNC patients, which was administered pretreatment and 3-months posttreatment. HPV presence was confirmed in only three patients (7.0 %). HPV positivity did not find any statistical correlation with age, gender, residence, addiction habit, stage, tumor size, nodal status, tumor grade, and number of sexual contacts. There was no significant (p > 0.05) difference in the average percent change in QOL parameters from pretreatment to posttreatment when correlated with HPV status.

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Quality of life in head and neck cancer patients: Impact of HPV and primary treatment modality

Abstract: 4.

Cited by 53 publications

References 23 publications

Preradiotherapy dental extractions and health-related quality of life

Preradiotherapy dental extractions and health-related quality of life

Trends in the 15D health-related quality of life over the first year following diagnosis of head and neck cancer

Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment—a Pilot Study from Northern India

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