Quality of life in infants with atopic dermatitis and healthy infants: a follow‐up from birth to 24 months

Alanne, Soili; Nermes, Merja; Söderlund, Riitta; Laitinen, Kirsi

doi:10.1111/j.1651-2227.2011.02229.x

Cited by 32 publications

(27 citation statements)

References 25 publications

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“…Atopic eczema (AE) is a common skin disease with a current prevalence of 10–15% in developed countries . AE has multiple manifestations such as erythema, skin dryness and pruritic skin lesions.…”

Section: Introductionmentioning

confidence: 99%

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

Smeden

Janssens

Kaye

et al. 2013

Experimental Dermatology

231

273

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An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfil a predominant role in the skin barrier function. In this clinical study, the carbon chain length distribution of SC lipids (FFAs and CERs) and their importance for the lipid organization and skin barrier function were examined in AE patients and compared with control subjects. A reduction in FFA chain length and an increase in unsaturated FFAs are observed in non-lesional and lesional SC of AE patients. The reduction in FFA chain length associates with a reduced CER chain length, suggesting a common synthetic pathway. The lipid chain length reduction correlates with a less dense lipid organization and a decreased skin barrier function. All changes are more pronounced in lesional SC compared with non-lesional skin. No association was observed between lipid properties and filaggrin mutations, an important predisposing factor for developing AE. The results of this study demonstrate an altered SC lipid composition and signify the importance of these changes (specifically regarding the CER and FFA chain lengths) for the impaired skin barrier function in AE. This provides insights into epidermal lipid metabolism as well as new opportunities for skin barrier repair.

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Section: Introductionmentioning

confidence: 99%

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

Smeden

Janssens

Kaye

et al. 2013

Experimental Dermatology

231

273

View full text Add to dashboard Cite

show abstract

“…The impact of AD on quality of life is well documented, with patients and families reporting the itch-scratch cycle and associated sleep impairments to be the most difficult aspects of the condition [10,11,12,13]. Sleep disruption due to pruritus is common, including difficulty with sleep onset, frequent awakenings, and reduced sleep efficiency [14,15,16,17].…”

Section: Introductionmentioning

confidence: 99%

A Review of Multidisciplinary Interventions in Atopic Dermatitis

Spielman

LeBovidge

Timmons

et al. 2015

JCM

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Multidisciplinary interventions have been developed for patients with atopic dermatitis (AD) and their families, with the aim of improving outcomes such as disease control, adherence, and quality of life. We reviewed the content of different multidisciplinary approaches to intervention for AD and evidence for their impact on key outcome measures. We also provided data from our multidisciplinary outpatient program for pediatric AD. Studies included in the review suggest benefits of multidisciplinary interventions as models of treatment or adjuncts to standard medical care, with a positive impact on outcomes including disease severity and itching/scratching. There were limitations to existing studies, including heterogeneous methods used to assess quality of life outcomes across studies and lack of controlled studies assessing the outcome of clinical care programs. Further research will be useful in assessing the impact of multidisciplinary interventions on important outcomes such as treatment adherence and sleep, identifying the elements of multidisciplinary interventions that are most critical for improved outcomes, and identifying the best candidates for multidisciplinary intervention approaches.

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“…Impaired quality of life is common in AD, both in children (patients and caregivers) and adults, and may also be observed in infants [104]. Several quality of life measures (disease-specific and generic) have been used to determine this [105].…”

Section: Severe Allergic and Related Diseasesmentioning

confidence: 99%

Severe Chronic Allergic (and Related) Diseases: A Uniform Approach – A MeDALL – GA<sup>2</sup>LEN – ARIA Position Paper

Bousquet¹,

Antó²,

Demoly³

et al. 2012

Int Arch Allergy Immunol

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Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.

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Quality of life in infants with atopic dermatitis and healthy infants: a follow‐up from birth to 24 months

Abstract: Simple treatment regimens targeting itching in particular are likely to contribute most to the QOL of infants with AD; however, sleeping problems may remain as an age-related phenomenon. Early detection of symptoms and effective parent guidance contributed to the well-being of the child.

Cited by 32 publications

References 25 publications

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients

A Review of Multidisciplinary Interventions in Atopic Dermatitis

Severe Chronic Allergic (and Related) Diseases: A Uniform Approach – A MeDALL – GA<sup>2</sup>LEN – ARIA Position Paper

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